Effect of Omega-3 Fatty Acids on Cardiovascular Diseases

Abstract

Cardiovascular disease is one of the leading causes of death that is rapidly increasing in developing countries, and is also a disease that affects the heart and blood vessels. When blood vessels become narrowed or blocked, heart attack and heart failure can occur. Since the 1940s, omega-3 fatty acids have been suggested to have benefits on cardiovascular disease. With the discovery that Greenland Inuit have about a third of atherosclerotic heart disease relative to the general population in Finland, omega-3 fatty acids have gained importance. Among the mechanisms suggested for the protective effects of omega-3 PUFAs in cardiovascular diseases; antiarrhythmic effects, improvements in autonomic function, decreased platelet aggregation, decreased blood pressure, improvements in endothelial function, plaque stabilization, and decreased atherosclerosis. Therefore, the purpose of this review is; To examine the effects of omega-3 fatty acids on cardiovascular diseases.

Keywords

• omega-3
• cardiovasküler
• heart diseases

Omega-3 Yağ Asitlerinin Kardiyovasküler Hastalıklar Üzerine Etkisi

Abstract

Kardiyovasküler hastalıklar, gelişmekte olan ülkelerde hızlı bir şekilde artış gösteren başlıca ölüm nedenlerinden biridir ve ayrıca kalbi ve kan damarlarını etkileyen bir hastalık türüdür. Kan damarları daraldığında veya tıkandığında, kalp krizi ve kalp yetmezliği ortaya çıkabilir. 1940'lardan beri, omega-3 yağ asitlerinin kardiyovasküler hastalıklar üzerine faydaları olduğu öne sürülmüştür. Grönland Inuitlerinin, Finlandiya'daki genel popülasyona göre aterosklerotik kalp hastalığının yaklaşık üçte birine sahip olduğunun keşfedilmesiyle birlikte, omega-3 yağ asitleri önem kazanmıştır. Omega-3 PUFA'ların kardiyovasküler hastalıklarda koruyucu etkileri için önerilen mekanizmalar arasında; antiaritmik etkiler, otonomik fonksiyonda iyileşmeler, azalmış trombosit agregasyonu, azalan kan basıncı, endotel fonksiyonunda iyileşmeler, plak stabilizasyonu ve azalmış ateroskleroz yer alır. Bu nedenle, bu derlemenin amacı; omega-3 yağ asitlerinin kardiyovasküler hastalıklar üzerindeki etkilerini incelemektir.

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