Cloacogenic Adenocarcinoma of the Vulva: Case Report

Year 2017, Volume: 3 Issue: 1, 35 - 40, 22.04.2017

Özben Yalçın Yalçin Polat Erdin İlter Ş.sinem Özbay , Duygu Düşmez Apa

Abstract

Primary villoglandular adenocarcinomas of the vulva are rare. Hypotheses about the origin of this neoplasm remains highly speculative. We reported the case of a 51-year-old woman with this very uncommon malignant tumor. Immunohistochemical studies of the tumor revealed positive staining for cytokeratins 7 and 20 and negative staining for estrogen and progesterone receptors. Special stains showed the presence of intracellular mucin. No other primary lesion was found on clinical evaluation and extensive investigation. The patient was treated by radical hemivulvectomy. The patient remained disease free for 16 months after the initial surgery.

Keywords

vulva; cloacogenic carcinoma; histopathology; immunopathology.

References

• [1] Nasir S, Zaidi H, Conner MC. Primary vulvar adenocarcinoma of cloacogenic origin. South Med J 2001; 94:744-746. [2] Rodriguez A, Isaac MA, Hidalgo E, et al. Villoglandular adenocarcinoma of the vulva. Gynecol Oncol 2001; 83:409-411, [3] Wilkinson EJ: Premalignant and malignant tumors of the vulva. In: Kurman RJ editor. Blaustein’s Pathology of the Female Genital Tract, New York: 5th edition., Springer-Verlag, 2002, pp 122-8 [4] Kennedy JC, Majmudar B. Primary adenocarcinoma of the vulva, possibly cloacogenic. A report of two cases. J Reprod Med 1993; 38:113-116. [5] Willen R, Békássy Z, Carlén, B., et al. Cloacogenic adenocarcinoma of the vulva. Gynecologic Oncology 1999; 74, 298-301. [6] Zaida SNH, Conner MG. Primary vulvar adenocarcinoma of cloacogenic origin. Southern Medical Journal 2001; 94, 744-746. [7] Dube V, Veilleux C, Plante M, et al. Primary villoglandular adenocarcinoma of cloacogenic origin of the vulva. Human Pathology 2004; 35, 377-379. [8] Lui SH, Ho CM, Huang, SH., et al. Cloacogenic adenocarcinoma of the vulva presenting as recurrent Bartholin’s gland infection. Journal of the Formosan Medical Association 2003; 102, 49-51. [9] Vale´Rie Dube, Chantal Veilleux, Marie Plante, Bernard TeTu. Primary villoglandular adenocarcinoma of cloacogenic origin of t he vulva. Hum Pathol 35:377-379. 2004 [10] Rajni c, Kimberly A, Wood CK, Giede AA, Unusually aggressive primary cloacogenic carcinoma of the vulva: Case Reports in Clinical Medicine 2013; 2 (5): 302-305