HEMOCHROMATOSIS AND HEPATOCELLULAR CARCINOMA

Year 2025, Volume: 11 Issue: 1, 1 - 31, 28.02.2025

Merve Çiğdem Özgel , Buğra Tuncer

Abstract

An autosomal recessive iron overload condition called hemochromatosis is typified by enhanced dietary iron sorption and hepatic iron buildup. It is a risk agent for hepatocellular carcinoma since it is a prevalent illness in the European population. One of the tumors that is most common and deadly around the globe, particularly in Asia, is hepatocellular carcinoma. Because it is often detected in its advanced stages, hepatocellular carcinoma has a weak prognosis. Early tumor detection improves the chances of a successful cure and a longer life. Because of this, the EASL (European Association for the Study of the Liver) instructions support liver tumor screening using ultrasound scanning every six months, regardless of liver condition.
This review focuses on the relationship between hemochromatosis, a rare disorder that is among the risk factors, and hepatocellular carcinoma.

Keywords

Hemochromatosis, Hepatocellular carcinoma, HFE gene, Iron, Iron overload

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