4-Nitro-N-(6-sülfamoilbenzotiazol-2-il)benzamidin Metal Komplekslerinin Sentezi ve Karakterizasyonu

Year 2025, Volume: 5 Issue: 2, 38 - 44, 28.11.2025

Halil İlkimen , Cengiz Yenikaya , Aysel Gülbandılar

https://doi.org/10.62425/atakim.1678727

Abstract

Bu çalışmada, 4-nitro-N-(6-sülfamoilbenzotiazol-2-il)benzamidin (abt) yeni Fe(II) {[Fe(abt)2(SO4)].H2O (1)}, Ni(II) {[Ni(abt)2(Ac)2].4H2O (2)} ve Cu(II) {[Cu(abt)2(Ac)2].4H2O (3)} kompleksleri sentezlendi. 1-3’ün yapıları, element analizi, AAS, molar iletkenlik ve manyetik duyarlılık yöntemleri ile önerildi. Spektroskopik değerlendirmenin bir sonucu olarak, 1-3 bileşiklerinin iyonik olmayan ve tetrahedral bir konformasyon sergilediği belirlendi. Tüm maddelerin C. albicans (maya), E. faecalis, E. coli, L. monocytogenes, S. aureus, P. aeruginosa ve B. subtilis (bakteri) duyarlılığına ilişkin kapsamlı bir inceleme yürütüldü ve kapsamlı bir şekilde araştırıldı. Antimikrobiyal aktiviteler Ketokonazol, Flukonazol, Levofloksasin, Kloramfenikol, Vankomisin ve Sefepim ile karşılaştırıldı. Bileşikler abt ve 2, S. aureus ve B. subtilis bakterilerinde daha iyi aktivite gösterirken, bileşikler 1-3, E. coli ve E. faecalis bakterilerinde ve C. albicans mayasında aynı aktiviteyi gösterdi. Kompleks 3, L. monocytogenes bakterilerinde daha iyi aktivite gösterdi.

Keywords

4-Nitro-N-(6-sülfamoilbenzotiazol-2-il)benzamid , metal kompleksi , tetrahedral kompleks , antimikrobiyal aktivite.

Synthesis and Characterization of Metal Complexes of 4-Nitro-N-(6-sulfamoylbenzothiazol-2-yl)benzamide

Abstract

In this study, the new Fe(II) {[Fe(abt)2(SO4)].H2O (1)}, Ni(II) {[Ni(abt)2(Ac)2].4H2O (2)} and Cu(II) {[Cu(abt)2(Ac)2].4H2O (3)} complexes of 4-nitro-N-(6-sulfamoylbenzothiazol-2-yl)benzamide (abt) were synthesized. The structures (1-3) were suggested by elemental analysis, AAS, molar conductivity, and magnetic susceptibility methods. As a consequence of spectroscopic evaluation, it was determined that compounds 1-3 exhibited a non-ionic and tetrahedral conformation. A comprehensive examination was conducted on the susceptibility of all substances to C. albicans (yeast), E. faecalis, E. coli, L. monocytogenes, S. aureus, P. aeruginosa, and B. subtilis (bacteria) were thoroughly investigated. The antimicrobial activities were contrasted with those of Ketoconazole, Fluconazole, Levofloxacin, Chloramphenicol, Vancomycin, and Cefepime. Compounds abt and 2 showed better activity in S. aureus and B. subtilis bacteria, while compounds 1-3 showed the same activity in E. coli and E. faecalis bacteria and C. albicans yeast. Complex 3 showed better activity in L. monocytogenes bacteria.

Keywords

4-Nitro-N-(6-sulfamoylbenzothiazol-2-yl)benzamide , metal complex , tetrahedral complex , antimicrobial activity.

Thanks

The authors acknowledge the support provided by Kütahya Dumlupınar University Research Fund (grant No. 2024/16).

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