Evaluation of the Effect of Ketoprofen on Haemostatic Parameters in Holstein Heifers Following Dehorning

Abstract

 

 Ketoprofen (KTP), an aryl propionic acid derivative, is a nonsteroidal anti-inflammatory drug (NSAID) with the potential of a strong non-selective inhibition of cyclooxygenase (COX). KTP mitigates dehorning pain in cattle. The coagulation status of the cattle has to be taken in to consideration prior to surgery in an attempt to prevent haemostatic alterations or dysfunction. In this study, the effect of administration of KTP on the coagulation profiles of Holstein heifers subjected to dehorning is evaluated. Heifers (n=7) were treated with KTP (2.2 mg/kg i.v.) for a single dose prior to dehorning. Fibrinogen (Fb), prothrombin time (PT), activated partial thromboplastin time (APTT) were determined prior to administration (0.) and 30, 60 and 90 minutes later. Taking into account the mean values (±SD) obtained, the PT was significantly increased on 30. minutes in contrast to initial values (P<0.05). Similarly, Fb concentration showed statistical significance on 60. minutes (P<0.05) in comparison to the initial values. Significant differences were not detected in other coagulation panel parameters at sampling times. In conclusion, i.v. administration of KTP at a single dose in heifers subjected to dehorning causes slight changes of selected haemostatic variables. KTP only caused elevations on PTT and Fb. Based on these results, when KTP is used in cattle before surgery for its analgesic effect, it should cause alterations on the haemostatic properties during the dehorning.

Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi

Abstract

Aril propiyonik asit türevi olan Ketoprofen (KTP) seçici olmayan güçlü bir siklooksijenaz (COX) inhibisyonu ile nonsteroidal anti-inflammatuar ilaçlar arasındadır. KTP sığırlarda boynuzsuzlaştırma ağrısını hafifletir. Sığırların pıhtılaşma özellikleri hemostatik değişiklikler veya fonksiyon bozuklularını önlemek amacıyla ameliyat öncesi dikkate alınmalıdır. Bu çalışmada boynuzsuzlaştırma işlemi uygulanan düvelerde KTP’nin koagülasyon profillerine olan etkisi değerlendirildi. Düvelere (n=7) boynuzsuzlaştırma öncesi KTP (2.2 mg/kg i.v.) tek doz uygulandı. Fibrinojen (F), protrombin zamanı (PT) ve active edilmiş parsiyel tromboplastin zamanı (APTT) uygulama öncesi (0.), 30., 60. ve 90 dakikalarda belirlendi. Ortalama değerler (±SD) dikkate alındığında, PT değerleri başlangıç değerlerinin aksine 30. dakikada belirgin bir artış oldu (P

Keywords

• Sığır, Boynuzsuzlaştırma, Hemostatik fonksiyon, Ketoprofen

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