Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats

Fatih Avdatek

doi:10.17094/ataunivbd.282980

Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats

Öz

Calcium ions are very important for many sperm functions involving sperm motility, reaction, and hyperactivation. The purpose of this study was to examine the effect of calcium channel blocker (CCB), Amlodipine (AML), on spermatological features, genital tract weight and spermatogenic cell density in adult male Wistar rats. Twelve rats (age, 12 weeks; weight, 290-350 g) were divided into two groups, six rats per each. Group I rats were fed normal diet without AML served as the control, Group II received 0.04 mg/daily AML for 30 days by oral gavage. Motility, left testis, right epididymis, prostate weight were decreased, and abnormal sperm rate was significantly (P<0.05) increased in AML groups compared with control group. The seminiferous tubular diameter and germinal cell layer thickness were not affected compared with control group. In conclusion, subacute administration of AML to male rats have detrimental effects on the spermatological parameters and genital tract weights, but not affect spermatogenic cell density of male rats.

Anahtar Kelimeler

Amlodipine,Rat,Spermatologic parametres

References

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Details

Primary Language

Turkish

Subjects

-

Journal Section

Research Article

Authors

Fatih Avdatek

Publication Date

December 30, 2016

Submission Date

January 2, 2017

Acceptance Date

November 28, 2016

Published in Issue

Year 2016 Volume: 11 Number: 3

DOI

https://doi.org/10.17094/ataunivbd.282980

IZ

https://izlik.org/JA83HD84HK

Cite

RIS / Bibtex

APA

Avdatek, F. (2016). Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 11(3), 267-272. https://doi.org/10.17094/ataunivbd.282980

AMA

1.Avdatek F. Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2016;11(3):267-272. doi:10.17094/ataunivbd.282980

Chicago

Avdatek, Fatih. 2016. “Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 11 (3): 267-72. https://doi.org/10.17094/ataunivbd.282980.

EndNote

Avdatek F (December 1, 2016) Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 11 3 267–272.

IEEE

[1]F. Avdatek, “Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats”, Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 11, no. 3, pp. 267–272, Dec. 2016, doi: 10.17094/ataunivbd.282980.

ISNAD

Avdatek, Fatih. “Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 11/3 (December 1, 2016): 267-272. https://doi.org/10.17094/ataunivbd.282980.

JAMA

1.Avdatek F. Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2016;11:267–272.

MLA

Avdatek, Fatih. “Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 11, no. 3, Dec. 2016, pp. 267-72, doi:10.17094/ataunivbd.282980.

Vancouver

1.Fatih Avdatek. Effects of Amlodipine on Spermatological Parameters and Genital Tract Weight in Adult Wistar Male Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2016 Dec. 1;11(3):267-72. doi:10.17094/ataunivbd.282980