Noradrenalinin, İn Vitro Koşullar Altında Besi Hindilerinde İnce ve Kalın Bağırsak Düz Kasları Üzerine Etkisi

Öz

Bu çalışmanın amacı heavy hybrid hindilerin ince ve kalın bağırsaklarındaki düz kaslarda bulunan adrenerjik reseptörlerin olası varlığını in vitro koşullar altında farklı konsantrasyonlarda non-selektif adrenerjik reseptör agonisti, noradrenalin, kullanarak belirlemektir. Çalışma 24 besi hindisinde gerçekleştirildi. Organ izolasyon cihazında duodenum, jejunum, ileum, çekum ve kolonun müsküler longitudinal ve sirküler tabakalarında testler farklı konsantrasyonlarda noradrenalin hydrogentartarate solüsyonu kullanılarak test edildi. Çalışma besi hindilerinin ince ve kalın bağırsaklarındaki düz kaslarda bulunan adrenerjik reseptörlerin olası varlığını ortaya koymdu. Noradrenalin’in longitudinal tabaka üzerindeki etkisi, besi hindilerinin ince ve kalın bağırsaklarında ki tunica muscularis sirküler tabaka üzerinde ki etkisinden daha güçlüydü (P<0.001). Farklı konsantrasyonlarda noradrenalin kullanımına ilişkin olarak elde edilen sonuçlarda da istatistiksel olarak anlamlı farklılıklar vardı. Noradrenalinin ince ve kalın bağırsakların farklı bölgelerindeki etkilerinde de önemli farklılıklar bulundu. Selektif agonistler ve α ve β reseptör antagonistleri kullanılarak, besi hindilerinin ince ve kalın bağırsak düz kaslarında daha fazla araştırma yapılması gerekmektedir.

Anahtar Kelimeler

• Noradrenaline,adrenergic receptors,fattening turkeys,small and large intestines,tunica muscularis

Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions

Abstract

The aim of the study was to determine the possible presence of adrenergic receptors in the smooth musculature of small and large intestines of heavy hybrid turkey, using different concentrations of non-selective adrenergic receptor agonists, noradrenaline, under in vitro conditions. The research was carried out on 24 fattening turkeys. Tests of circular and longitudinal layers of muscular duodenum, jejunum, ileum, cecum and colon in the organ isolation apparatus, using different concentrations of noradrenaline hydrogentartarate solution, were tested. The research has established the presence of adrenergic receptors within the smooth musculature of the small and large intestines of fattening turkeys. The effect of the noradrenaline on the longitudinal layer was stronger (P<0.001) than the effect on the circular layer of tunica muscularis in small and large intestines of fattening turkeys. There were also statistically significant differences in the results obtained with regard to the use of different concentrations of noradrenaline. Significant differences in the effects of noradrenaline in different parts of the small and large intestines have also been established. Further research into smooth musculature of the small and large intestines of fattening turkeys is needed, with the use of selective agonists and α and β receptor antagonists.

Keywords

• Noradrenaline,adrenergic receptors,fattening turkeys,small and large intestines,tunica muscularis

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