Koyunlara Damar İçi ve Kas İçi Tek Doz Uygulanan Uzun Etkili Oksitetrasiklinin Biyoyararlanımı ve Farmakokinetiği Üzerine Prednizolonun Etkisi

Abstract

Bu çalışmada, koyunlara tek doz (20 mg/kg, canlı ağırlık) kas içi ve damar içi uygulandıktan sonra uzun etkili oksitetrasiklinin farmakokinetiği ve prednizolon ile eş-zamanlı kas içi uygulamayı takiben de muhtemel farmakokinetik etkileşimin belirlenmesi amaçlandı. İlacın plazma yoğunluğu ELISA prosedürü ile ölçüldü. Kas içi ve damar içi uygulamadan sonra oksitetrasiklinin plazma yoğunluğu-zaman eğrisinin iki bölmeli açık modele uygunluğu tüm kinetik hesaplamalarda dikkate alındı. Oksitetrasiklin ve prednizolonun kas içi yolla kombine tarzda eş-zamanlı olarak uygulanması sonrası elde edilen farmakokinetik parametreler, tek başına uygulanan ilaç parametreleri ile benzerlik gösterdi (p > 0.05). Dolayısıyla, sonuç olarak, uzun etkili oksitetrasiklinin tek başına veya prednizolon ile birlikte uygulandığında plazmada 48 saat boyunca ortalama terapötik düzeyi sağladığı ve prednizolonla birlikte uygulama durumunda ise olumlu veya olumsuz herhangi bir etkileşimin olmadığı kanısına varıldı.

Keywords

• Farmakokinetik, Koyun, Oksitetrasiklin, Prednizolon

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