Hücre Adezyon Molekülleri

Abstract

Organizmada hücreler arası uyum, yaşamın devamlılığının temel kuralını oluşturmaktadır. Bu uyum, çeşitli hücre içi ve hücre dışı faktörler yardımıyla gerçekleştirilmektedir. Bu faktörlerin bir grubunu hücre adezyon molekülleri oluşturur. Hücre adezyon molekülleri; integrinler, selektinler, immunoglobulin süper ailesi ve kaderinler olmak üzere 4 grupta toplanır. Prenatal ve postnatal dönemlerde hücrede meydana gelen gelişim aşamaları; hücresel proliferasyon, göç, farklılaşma ve olgunlaşmada görev alırlar. Hücre hareketlerinin organizasyonunda, immun ve inflamatuvar yanıtın ortaya çıkmasında da oldukça önemli rolleri vardır. Bu derlemede adezyon moleküllerinin yapısal özellikleri ve bu özelliklere bağlı olarak hücreler arası etkileşimdeki fonksiyonları değerlendirilmektedir.

Keywords

• Hücre adezyon molekülleri, İmmunglobulin süper ailesi, İntegrinler, Kaderinler, Selektinler

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