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Protective Effect of Panax ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats
Abstract
This study was designed to investigate the protective effects of Panax ginseng against acute brain damage induced by CCl4 in rats. A total of 30 healthy female Sprague–Dawley rats were divided in to three groups. Sedentary control group (group C) injected intraperitoneally (i.p.) with physiological saline as placebo for 7 consecutive days. CCl4 toxication group was injected by i.p. a single dose of CCl4 (group CCl4). Panax ginseng plus CCl4 group (200 mg/kg) was feeding through an orogastric tube for 7 consecutive days prior to CCl4 injection (group CCl4 + PG). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and nitric oxide (NO). Panax ginseng showed a significant brain-protective effect by decreasing the level of lipid peroxidation (MDA) and elevated the activities of GSH and SOD (p<0.05). Consequently Panax ginseng was blocked oxidative brain damage induced by CCl4 in rats
Keywords
Details
Primary Language
Turkish
Subjects
-
Journal Section
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Publication Date
September 7, 2015
Submission Date
March 31, 2010
Acceptance Date
-
Published in Issue
Year 2007 Volume: 2 Number: 3
APA
Karadeniz, A., Yıldırım, A., & Çelebi, F. (2015). Protective Effect of Panax ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 2(3). https://izlik.org/JA24MH68FB
AMA
1.Karadeniz A, Yıldırım A, Çelebi F. Protective Effect of Panax ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2015;2(3). https://izlik.org/JA24MH68FB
Chicago
Karadeniz, Ali, Abdulkadir Yıldırım, and Fikret Çelebi. 2015. “Protective Effect of Panax Ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 2 (3). https://izlik.org/JA24MH68FB.
EndNote
Karadeniz A, Yıldırım A, Çelebi F (September 1, 2015) Protective Effect of Panax ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 2 3
IEEE
[1]A. Karadeniz, A. Yıldırım, and F. Çelebi, “Protective Effect of Panax ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats”, Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 2, no. 3, Sept. 2015, [Online]. Available: https://izlik.org/JA24MH68FB
ISNAD
Karadeniz, Ali - Yıldırım, Abdulkadir - Çelebi, Fikret. “Protective Effect of Panax Ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 2/3 (September 1, 2015). https://izlik.org/JA24MH68FB.
JAMA
1.Karadeniz A, Yıldırım A, Çelebi F. Protective Effect of Panax ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2015;2. Available at https://izlik.org/JA24MH68FB.
MLA
Karadeniz, Ali, et al. “Protective Effect of Panax Ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 2, no. 3, Sept. 2015, https://izlik.org/JA24MH68FB.
Vancouver
1.Ali Karadeniz, Abdulkadir Yıldırım, Fikret Çelebi. Protective Effect of Panax ginseng Against Carbon Tetrachloride (CCl4) - Induced Oxidative Brain Injury in Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi [Internet]. 2015 Sep. 1;2(3). Available from: https://izlik.org/JA24MH68FB