Östrojen- bağımlı Meme Kanseri ve Sodyum-bağımlı Steroid Sülfat Taşıyıcısı SOAT

Abstract

ÖZET: Meme kanseri kadınlarda en sık gözlenen kanser türüdür ve %95’i hormon bağımlı olarak gelişir. Postmenopozal dönemde aktif östrojen plazma seviyesi biyolojik etki konsantrasyonunun altında olmasına rağmen, östrojen-bağımlı meme kanserinin üçte ikisi bu dönemde ortaya çıkmaktadır. Buna karşın plazmada mikromolar düzeyde inaktif östrojen olan Steroid-sülfatlar bulunmaktadir. Özellikle postmenoposal kadında steroid sülfatlardan intratümöral hormonal aktif östrojen üretimi meme kanseri hücrelerinin proliferasyonunda önemli rol oynar. Ancak steroid sülfatlar hidrofilik yapılarından dolayı intraselüler taşınmada bir membran taşıyıcısına ihtiyaç duymaktadır. Bugüne kadar steroid sülfatların meme dokusu tümör hücrelerindeki taşınma mekanizması geniş kapsamlı olarak açıklığa kavuşturulamamıştır. Bu derlemede SLC ailesinin yeni bir üyesi olan “sodyuma-bağımlı organik anyon taşıyıcısı” nın (Sodium dependent Organic Anion Transporter- SOAT) postrmenopozal dönemde görülen östrojen-bağımlı meme kanserindeki rolü vurgulanacaktır.

Keywords

• Meme kanseri, SOAT, Steroid sülfat

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