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Evaluation of the Effect of Ketoprofen on Haemostatic Parameters in Holstein Heifers Following Dehorning

Year 2016, Volume: 11 Issue: 2, 0 - 0, 31.10.2016
https://doi.org/10.17094/avbd.34295

Abstract

 

 Ketoprofen (KTP), an aryl propionic acid derivative, is a nonsteroidal anti-inflammatory drug (NSAID) with the potential of a strong non-selective inhibition of cyclooxygenase (COX). KTP mitigates dehorning pain in cattle. The coagulation status of the cattle has to be taken in to consideration prior to surgery in an attempt to prevent haemostatic alterations or dysfunction. In this study, the effect of administration of KTP on the coagulation profiles of Holstein heifers subjected to dehorning is evaluated. Heifers (n=7) were treated with KTP (2.2 mg/kg i.v.) for a single dose prior to dehorning. Fibrinogen (Fb), prothrombin time (PT), activated partial thromboplastin time (APTT) were determined prior to administration (0.) and 30, 60 and 90 minutes later. Taking into account the mean values (±SD) obtained, the PT was significantly increased on 30. minutes in contrast to initial values (P<0.05). Similarly, Fb concentration showed statistical significance on 60. minutes (P<0.05) in comparison to the initial values. Significant differences were not detected in other coagulation panel parameters at sampling times. In conclusion, i.v. administration of KTP at a single dose in heifers subjected to dehorning causes slight changes of selected haemostatic variables. KTP only caused elevations on PTT and Fb. Based on these results, when KTP is used in cattle before surgery for its analgesic effect, it should cause alterations on the haemostatic properties during the dehorning.

References

  • Anonymous 1., 2007. USDA: Dairy 2007, Heifer Calf Health and Management Practices on U.S. Dairy Operations.
  • Coetzee JF., Mosher RA., KuKanich B., Gehring R., Robert B., Reinbold JB., White BJ., 2012. Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia. BMC Veterinary Research, 8, 153-167.
  • Marongiu ML., 2012. Local Anesthesia for Husbandry Procedures and Experimental Purposes in Farm Animals. 242-253, INTECH Open Access Publisher.
  • Holmdah L., Ivarsson M., 1999. The role of cytokines, coagulation and fibrino-lysis in peritoneal tissue repair. European Journal of Surgery, 165, 1012-1019.
  • Faulkner PM., Weary DM., 2000. Reducing pain after dehorning in dairy calves. Journal of Dairy Science, 83, 2037-2041.
  • Sutherland MA., Mellor DJ., Stafford KJ., Gregory NG., Bruce RA., Ward RN., 2002. Modification of cortisol responses to dehorning in calves using a 5-hour local anaesthetic regimen plus phenylbutazone, ketoprofen or adrenocorticotropic hormone injected prior to dehorning. Research in Veterinary Science, 73, 115-123. 7. Van Nydam D., Nydam CW., 2004. Dehorning/Cornuectomy. In “Farm Animal Surgery”, Eds., S Fubini, N Ducharme, 132-138, lsevier, Missouri, USA.
  • Stock ML., Baldridge SL., Griffin D., Coetzee JF., 2013. Bovine dehorning, assessing pain and providing analgesic management. Veterinary Clinics of North America: Food Animal Practice, 29, 103-133.
  • Wohlt JE., Allyn ME., Zajac PK., Katz LS., 1994. Cortisol increases in plasma of Holstein heifer calves from handling and method of electrical dehorning. Journal of Dairy Science, 77, 3725- 3729.
  • Sylvester SP., Mellor DJ., Stafford KJ., Bruce RA., Ward RN., 1998. Acute cortisol responses of calves to scoop dehorning using local anaesthesia and/or cautery of the wound. Australian Veterinary Journal, 76, 118-122.
  • Graf B. Senn M., 1999. Behavioural and physiological responses of calves to dehorning by heat cauterisation with or without local anesthesia. Applied Animal Behaviour Science, 62, 153-171.
  • Grondahl-Nielsen C., Simonsen H.B., Damkjer L.J., Hesselholt H., 1999. Behavioural, endocrine and cardiac responses in young calves undergoing dehorning without and with the use of sedation and analgesia. The Veterinary Journal, 158, 14- 20.
  • Morisse JP., Cotte JP., Huonnic D., 1995. Effect of dehorning on behaviour and plasma cortisol responses in young calves. Applied Animal Behaviour Science, 43, 239-247.
  • Petrie NJ., Mellor DJ., Stafford KJ., Bruce RA., Ward RN., 1996. Cortisol responses of calves to two methods of disbudding used with or without local anaesthetic. New Zealand Veterinary Journal, 44, 9-14.
  • McMeekan CM., Mellor DJ., Stafford KJ., Bruce RA., Ward RN., Gregory NG., 1998. Effects of local anaesthesia of 4 to 8 hours duration on the acute cortisol response to scoop dehorning in calves. Australian Veterinary Journal, 76, 281-285.
  • McMeekan CM., Mellor DJ., Stafford KJ., Bruce RA., Ward RN., Gregory NG., 1998. Effects of regional analgesia and/or non-steroidal anti- inflammatory analgesic on the acute cortisol response to dehorning calves. Research in Veterinary Science, 64, 147-150.
  • Boothe DM., 2001. The analgesic, antipyretic, antiinflammatory drugs. In “Veterinary Pharmacology and Therapeutics”, Ed., HR Adams, 8th ed., 433-451, LowaState University Press, USA.
  • Papich MG., 1997. Principles of analgesic drug therapy. Seminars in Veterinary Medicine and Surgery, 12, 80‑93.
  • Relford R., 1992. Diagnosis of platelet disorders. Seminars in Veterinary Medicine and Surgery, 7, 323‑329.
  • Schafer AI., 1995. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. The Journal of Clinical Pharmacology, 35, 209‑219.
  • Donnelly MT., Hawkey CJ., 1997. COX-II inhibitors–a new generation of safer NSAIDs? Alimentary Pharmacology and Therapeutics, 11, 227‑236.
  • Thompson L., 2006. Anti-inflammatory Agents. In “Merck Veterinary Manual”, Ed., CM Kahn, 51st Merck & Co, Inc, NJ, USA.
  • Cabre F., Fernandez MF., Zapatero MI., Arano A., Garcia ML., Mauleon D., 1998. Intestinal ulcerogenic effect of S (+)-ketoprofen in the rat. The Journal of Clinical Pharmacology, 38, 27-32.
  • Collins AJ., Davis J., Dixon ASJ., 1998. A prospective endoscopic study of the effect of orudis and oruvail on the upper gastrointestinal tract, in patients with osteoarthritis. British Journal of Rheumatology, 27, 106-109.
  • Jerussi TP., Caubet JF., McCray JE., Handley DA., 1998. Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial. The Journal of Clinical Pharmacology, 38, 19-24.
  • Narita T., Tomizawa N., Sato R., Goryo M., Hara S., 2005. Effects of long-term oral administration of ketoprofen in clinically healthy beagle dogs. The Journal of Veterinary Medical Science, 67, 847- 853.
  • Luna SP., Basilio AC., Steagall PV., Machado LP., Moutinho FQ., Takahira RK., Brandao CV., 2007. Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. American Journal of Veterinary Research, 68, 258-264.
  • Milligan BN., Duffield T., Lissemore K., 2004. The utility of ketoprofen for alleviating pain following dehorning in young dairy calves. The Canadian Veterinary Journal, 45, 140-143.
  • Vaden SL., Knoll JS., Smith FWK., Tilley LP., 2009. Blackwell´s five-minute veterinary consult: Laboratory tests and diagnostic procedures. 763, Canine & Feline. Willey-Blackwell, USA.
  • Rauser P., Lexmaulova L., Srnec R., Urbanova L., Proks P., Necas A., 2011. Effects of carprofen or meloxicam on selected haemostatic variables in miniature pigs after orthopaedic surgery. Acta Veterinaria Brno, 80, 401-405.

Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi

Year 2016, Volume: 11 Issue: 2, 0 - 0, 31.10.2016
https://doi.org/10.17094/avbd.34295

Abstract

Aril propiyonik asit türevi olan Ketoprofen (KTP) seçici olmayan güçlü bir siklooksijenaz (COX) inhibisyonu ile nonsteroidal anti-inflammatuar ilaçlar arasındadır. KTP sığırlarda boynuzsuzlaştırma ağrısını hafifletir. Sığırların pıhtılaşma özellikleri hemostatik değişiklikler veya fonksiyon bozuklularını önlemek amacıyla ameliyat öncesi dikkate alınmalıdır. Bu çalışmada boynuzsuzlaştırma işlemi uygulanan düvelerde KTP’nin koagülasyon profillerine olan etkisi değerlendirildi. Düvelere (n=7) boynuzsuzlaştırma öncesi KTP (2.2 mg/kg i.v.) tek doz uygulandı. Fibrinojen (F), protrombin zamanı (PT) ve active edilmiş parsiyel tromboplastin zamanı (APTT) uygulama öncesi (0.), 30., 60. ve 90 dakikalarda belirlendi. Ortalama değerler (±SD) dikkate alındığında, PT değerleri başlangıç değerlerinin aksine 30. dakikada belirgin bir artış oldu (P

References

  • Anonymous 1., 2007. USDA: Dairy 2007, Heifer Calf Health and Management Practices on U.S. Dairy Operations.
  • Coetzee JF., Mosher RA., KuKanich B., Gehring R., Robert B., Reinbold JB., White BJ., 2012. Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia. BMC Veterinary Research, 8, 153-167.
  • Marongiu ML., 2012. Local Anesthesia for Husbandry Procedures and Experimental Purposes in Farm Animals. 242-253, INTECH Open Access Publisher.
  • Holmdah L., Ivarsson M., 1999. The role of cytokines, coagulation and fibrino-lysis in peritoneal tissue repair. European Journal of Surgery, 165, 1012-1019.
  • Faulkner PM., Weary DM., 2000. Reducing pain after dehorning in dairy calves. Journal of Dairy Science, 83, 2037-2041.
  • Sutherland MA., Mellor DJ., Stafford KJ., Gregory NG., Bruce RA., Ward RN., 2002. Modification of cortisol responses to dehorning in calves using a 5-hour local anaesthetic regimen plus phenylbutazone, ketoprofen or adrenocorticotropic hormone injected prior to dehorning. Research in Veterinary Science, 73, 115-123. 7. Van Nydam D., Nydam CW., 2004. Dehorning/Cornuectomy. In “Farm Animal Surgery”, Eds., S Fubini, N Ducharme, 132-138, lsevier, Missouri, USA.
  • Stock ML., Baldridge SL., Griffin D., Coetzee JF., 2013. Bovine dehorning, assessing pain and providing analgesic management. Veterinary Clinics of North America: Food Animal Practice, 29, 103-133.
  • Wohlt JE., Allyn ME., Zajac PK., Katz LS., 1994. Cortisol increases in plasma of Holstein heifer calves from handling and method of electrical dehorning. Journal of Dairy Science, 77, 3725- 3729.
  • Sylvester SP., Mellor DJ., Stafford KJ., Bruce RA., Ward RN., 1998. Acute cortisol responses of calves to scoop dehorning using local anaesthesia and/or cautery of the wound. Australian Veterinary Journal, 76, 118-122.
  • Graf B. Senn M., 1999. Behavioural and physiological responses of calves to dehorning by heat cauterisation with or without local anesthesia. Applied Animal Behaviour Science, 62, 153-171.
  • Grondahl-Nielsen C., Simonsen H.B., Damkjer L.J., Hesselholt H., 1999. Behavioural, endocrine and cardiac responses in young calves undergoing dehorning without and with the use of sedation and analgesia. The Veterinary Journal, 158, 14- 20.
  • Morisse JP., Cotte JP., Huonnic D., 1995. Effect of dehorning on behaviour and plasma cortisol responses in young calves. Applied Animal Behaviour Science, 43, 239-247.
  • Petrie NJ., Mellor DJ., Stafford KJ., Bruce RA., Ward RN., 1996. Cortisol responses of calves to two methods of disbudding used with or without local anaesthetic. New Zealand Veterinary Journal, 44, 9-14.
  • McMeekan CM., Mellor DJ., Stafford KJ., Bruce RA., Ward RN., Gregory NG., 1998. Effects of local anaesthesia of 4 to 8 hours duration on the acute cortisol response to scoop dehorning in calves. Australian Veterinary Journal, 76, 281-285.
  • McMeekan CM., Mellor DJ., Stafford KJ., Bruce RA., Ward RN., Gregory NG., 1998. Effects of regional analgesia and/or non-steroidal anti- inflammatory analgesic on the acute cortisol response to dehorning calves. Research in Veterinary Science, 64, 147-150.
  • Boothe DM., 2001. The analgesic, antipyretic, antiinflammatory drugs. In “Veterinary Pharmacology and Therapeutics”, Ed., HR Adams, 8th ed., 433-451, LowaState University Press, USA.
  • Papich MG., 1997. Principles of analgesic drug therapy. Seminars in Veterinary Medicine and Surgery, 12, 80‑93.
  • Relford R., 1992. Diagnosis of platelet disorders. Seminars in Veterinary Medicine and Surgery, 7, 323‑329.
  • Schafer AI., 1995. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. The Journal of Clinical Pharmacology, 35, 209‑219.
  • Donnelly MT., Hawkey CJ., 1997. COX-II inhibitors–a new generation of safer NSAIDs? Alimentary Pharmacology and Therapeutics, 11, 227‑236.
  • Thompson L., 2006. Anti-inflammatory Agents. In “Merck Veterinary Manual”, Ed., CM Kahn, 51st Merck & Co, Inc, NJ, USA.
  • Cabre F., Fernandez MF., Zapatero MI., Arano A., Garcia ML., Mauleon D., 1998. Intestinal ulcerogenic effect of S (+)-ketoprofen in the rat. The Journal of Clinical Pharmacology, 38, 27-32.
  • Collins AJ., Davis J., Dixon ASJ., 1998. A prospective endoscopic study of the effect of orudis and oruvail on the upper gastrointestinal tract, in patients with osteoarthritis. British Journal of Rheumatology, 27, 106-109.
  • Jerussi TP., Caubet JF., McCray JE., Handley DA., 1998. Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial. The Journal of Clinical Pharmacology, 38, 19-24.
  • Narita T., Tomizawa N., Sato R., Goryo M., Hara S., 2005. Effects of long-term oral administration of ketoprofen in clinically healthy beagle dogs. The Journal of Veterinary Medical Science, 67, 847- 853.
  • Luna SP., Basilio AC., Steagall PV., Machado LP., Moutinho FQ., Takahira RK., Brandao CV., 2007. Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. American Journal of Veterinary Research, 68, 258-264.
  • Milligan BN., Duffield T., Lissemore K., 2004. The utility of ketoprofen for alleviating pain following dehorning in young dairy calves. The Canadian Veterinary Journal, 45, 140-143.
  • Vaden SL., Knoll JS., Smith FWK., Tilley LP., 2009. Blackwell´s five-minute veterinary consult: Laboratory tests and diagnostic procedures. 763, Canine & Feline. Willey-Blackwell, USA.
  • Rauser P., Lexmaulova L., Srnec R., Urbanova L., Proks P., Necas A., 2011. Effects of carprofen or meloxicam on selected haemostatic variables in miniature pigs after orthopaedic surgery. Acta Veterinaria Brno, 80, 401-405.
There are 29 citations in total.

Details

Journal Section Araştırma Makaleleri
Authors

Umit Karademir This is me

İbrahim Akın

Kerem Ural This is me

Publication Date October 31, 2016
Published in Issue Year 2016 Volume: 11 Issue: 2

Cite

APA Karademir, U., Akın, İ., & Ural, K. (2016). Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 11(2). https://doi.org/10.17094/avbd.34295
AMA Karademir U, Akın İ, Ural K. Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. October 2016;11(2). doi:10.17094/avbd.34295
Chicago Karademir, Umit, İbrahim Akın, and Kerem Ural. “Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 11, no. 2 (October 2016). https://doi.org/10.17094/avbd.34295.
EndNote Karademir U, Akın İ, Ural K (October 1, 2016) Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 11 2
IEEE U. Karademir, İ. Akın, and K. Ural, “Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi”, Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 11, no. 2, 2016, doi: 10.17094/avbd.34295.
ISNAD Karademir, Umit et al. “Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 11/2 (October 2016). https://doi.org/10.17094/avbd.34295.
JAMA Karademir U, Akın İ, Ural K. Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2016;11. doi:10.17094/avbd.34295.
MLA Karademir, Umit et al. “Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 11, no. 2, 2016, doi:10.17094/avbd.34295.
Vancouver Karademir U, Akın İ, Ural K. Holstein Düvelerde Boynuzsuzlaştırmayı Takiben Ketoprofenin Hemostatik Parametrelere Etkisinin Değerlendirilmesi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2016;11(2).