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Metallotiyoninlerin Histofizyolojik Önemi

Year 2007, Volume: 2 Issue: 2, 75 - 81, 31.03.2010

Nejdet Şimşek Belma Alabay

Abstract

Metallotiyoninler (MT) düşük molekül ağırlıklı (6000-7000 Da), 20 sistein molekülü içeren 61 amino asitli hücre içi proteinlerdir. MT proteini çinko, bakır, kadmiyum, civa, kurşun gibi metalleri bağlama yeteneğine sahiptir. Bu proteinler akciğer, böbrek, pankreas ve karaciğerin paranşimal hücrelerinde, barsakların epitellerinde, sertoli hücrelerinde, timulin içeren timus epitel hücrelerinde, germinatif hücrelerde, miyoepitel hücrelerinde normal olarak bol miktarda bulunmaktadır. MT’lerin önemi; ağır metallerin ve iz elementlerin homeostazisinde, detoksifikasyonunda ve taşınmasında görev almasıdır. Ayrıca, MT’ler hemhücrelerin gelişmesinde hem de apoptozis ve nekrozis gibi hücre ölümleriyle de ilşkileri bulunmaktadır.

Keywords

Metallotiyoninler ağır metaller iz elementler

References

  • Bay, B-H., Jin, R., Huang, J., Tan, P-H. (2006). Metallothionein as a Prognostic Biomarker in Breast Cancer. Exp. Biol. Med. 231, 1516–1521.
  • Beyersmann, D. (2002). Homeostasis and Cellular Functions of Zinc, Mat.-wiss. U. Werkstofftech. 33, 764–769.
  • Brüwer, M., Schmid, K.W., Metz, K.A., Krieglstein, C.F., Senninger, N., Schürmann, G. (2001). Increased Expression of Metallothionein in Inflammatory Bowel Disease, Inflamm. res. 50, 289–293.
  • Coyle, P., Philcoxa, J.C., Careya, L.C., Rofea, A.M. (2002). Metallothionein: The Multipurpose Protein CMLS, Cell. Mol. Life Sci. 59, 627–647.
  • Dameron, C.T., Harrison M.D. (1998 suppl). Mechanisms for Protection against Copper Toxicity1–3 Am.j.Clin Nutr 67:1091S–7S.
  • Davis, S.R., Cousins, R.J. (2000). Metallothionein Expression in Animals: A Physiological Perspective on Function, J. Nutr. 130: 1085– 1088,
  • Deng, D.X., Cai, L., Chakrabarti, S., Cherian, M.G. (1999). Increased Radiation-induced Apoptosis in Mouse Thymus in the Absence of Metallothionein, Toxicology 134, 39–49.
  • Ebert, M.P.A., Gu¨ Nther T., Hoffmann , J., Yu, J., Miehlke, S., Schulz, H.U., Roessner, A., Korc, M., Malfertheiner, P. (2000). Expression of Metallothionein II in Intestinal Metaplasia, Dysplasia, and Gastric Cancer, Cancer Research 60, 1995–2001.
  • Fleet, J.C., Qureshi, M.A., Dietert, R.R., McCormick, C.C. (1988). Tissue- Specific Accumulation of Metallothionein in Chickens as Influenced by the Route of Zinc, J.Nutr. 118: 176–182.
  • El Ghazi, I. Martin, B. L., Armitage I.M.(2006). Metallothionein-3 Is a component of a Multiprotein Complex in the Mouse Brain. Exp. Biol. Med., 231,1500–1506.
  • Hahn, S.H., Yoo, O.J., Gahl, W.A. (2001). Effect of Metal Ions on the Stability of Metallothionein in the Degradation by Cellular Fractions in vitro Experimental and Molecular Medicine, 33, 32–36.
  • Hidalgo, J., Penkowa, M., Espejo, C., Marti´NezCa´ Ceres, E.M. Carrasco, J., Quintana, A., Molinero, A., Florit, S., Giralt, M., OrtegaAznar A. (2006). Expression of Metallothionein-I, -II, and –III in Alzheimer Disease and Animal Models of Neuroinflammation. Exp. Biol. Med., 231,1450–1458.
  • Horky, D., Lauschova, I., Illek, J., Pechova,A., Sindelar, M. (2002). Distribution of Exogenous Heavy Metals in the Hepatocytes of Calves: A Morphometric Study Microscopy Research And Technique 56, 451–453.
  • Kim, B.J., Kim, Y.H., Kim, S., Kim, J.W., Koh, J.Y., Oh, S.H., Lee, M.K., Kim, K.W., Lee, M.S. (2000). Zinc as a paracrine Effector in Pancreatic Islet Cell Death, Diabetes 49, 367–372.
  • Kojima, S., Shimada, A., Morita, T., Yamano, Y., Umemura, T (1999). Localization of Metallothioneins-I & -II and -III in the Brain of Aged Dog. J. Vet. Med. Sci. 61, 343–349.
  • McCormick, C.C. (1984). Induction and Accumulation of Metallothionein in Liver and Pancreas of Chicks Given Oral Zinc: A Tissue Comparison. J. Nutr. 114, 191–203.
  • Mocchegiani, E., Verbanac, D., Santarelli, L., Tibaldi, A., Muzzioli, M., Radosevic-Stasic, B., Milin, C. (1997). Zinc and Metallothioneins on Cellular Immune Effectiveness During Liver Regeneration in Young and Old Mice, Life Sciences 61, 1125–1145.
  • Margoshes, M, Vallee, B. (1957). A cadmium protein from equine kidney cortex. J Am. Chem. Soc. 79, 4813–4814.
  • Minami, T., Kubo, K., Ichida, S. (2002). Determination of Metallothionein-1 / Metallothionein-2 Ratios in the Mouse Liver and Pancreas by Capillary Zone Electrophoresis using a Polyacrylamidecoated Capillary at Neutral pH. Journal of Chromatography B, 779, 211–219.
  • Minami, T., Shimizu, M., Tanaka, H., Okazaki, Y., Cherian, M.G. (1999). Metallothionein does not Protect Mouse Endocrine Cells from Damage Induced by Alloxan. Injection Toxicology, 132, 33–41.
  • Onosaka, S., Tetsuchikawahara, N., Min, K-S. (2002). Paradigm Shift in Zinc: Metal Pathology. Tohoku J. Exp. Med. 196, 1–7.
  • Ohly, P., Dohle, C., Abel, J., Seissler, J., Gleichmann, H. (2000). Zinc Sulphate Induces Metallothionein in Pancreatic Islets of mice and Protects Against Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetologia, 43, 1020– 1030.
  • Philcox, J.C., Sturkenboom, M., Coyle P., Rofe, A.M. (2000). Metallothionein in Mice Reduces Intestinal Zinc Loss during Acute Endotoxin Inflammation, but Not during Starvation or Dietary Zinc Restriction. J. Nutr. 130, 1901–1909.
  • Sanz- Nebot, V., Andón, B., Barbosa, J.(2003). Characterization of metallothionein isoforms from rabbit liver by liquid chromatography coupled to electrospray mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.796, 379–393.
  • Solis-Heredia, M.J., Quintanilla-Vega, B., SierraSantoyo, A., Hernandez, J.M., Brambila, E., Cebrian, M.E., Albores, A. (2000). Chromium Increases Pancreatic Metallothionein in the Rat. Toxicology, 142, 111–117.
  • Sozmen, M., Erginsoy, Sd., Cenesiz, S., Devrim, A.K. (2005). The Protective Effect of Kefir and Vitamin C on Azoxymethane Induced Toxicity and Induction of Metallothionein in Mice. Scand. J. Lab. Anim. Sci. 32, 211– 220.
  • Sprietsma, J.E., Schuitemaker, G.E. (1994). Diabetes can be Prevented by Reducing Insulin Production, Med Hypotheses 42, 15– 23.
  • Swiergosz-Kowalewska, R. (2001). Cadmium Distribution and Toxicity in Tissues of Small Rodents. Microscopy Research and Technique 55, 208–222.
  • Tomita, T. (2000). Metallothionein in Pancreatic Endocrine Neoplasms. Mod. Pathol., 13, 389–395.
  • Tomita, T., Matsubara, O. (2000). Immunocytochemical Localization of Metallothionein in Human Pancreatic Islets. Pancreas, 20, 21–24.
  • Yang, J., Cherian, M.G. (1994). Protective Effects of Metallothionein on Streptozotocininduced Diabetes in Rats. Life Sci. 55, 43– 51.
  • Zambenedetti, P., Giordano, R., Zatta. P. (1998). Metallothioneins are Highly Expressed in Astrocytes and Microcapillaries in Alzheimer's Disease. Journal of Chemical Neuroanatomy 15 (1998) 21-60
  • Zhou, Z., Sun, X. and Kang, Y.J. (2002). Metallothionein Protection against Alcoholic Liver Injury through Inhibition of Oxidative Stres. Exp. Biol. Med., 227, 214–222.

Year 2007, Volume: 2 Issue: 2, 75 - 81, 31.03.2010

Nejdet Şimşek Belma Alabay

Abstract

References

  • Bay, B-H., Jin, R., Huang, J., Tan, P-H. (2006). Metallothionein as a Prognostic Biomarker in Breast Cancer. Exp. Biol. Med. 231, 1516–1521.
  • Beyersmann, D. (2002). Homeostasis and Cellular Functions of Zinc, Mat.-wiss. U. Werkstofftech. 33, 764–769.
  • Brüwer, M., Schmid, K.W., Metz, K.A., Krieglstein, C.F., Senninger, N., Schürmann, G. (2001). Increased Expression of Metallothionein in Inflammatory Bowel Disease, Inflamm. res. 50, 289–293.
  • Coyle, P., Philcoxa, J.C., Careya, L.C., Rofea, A.M. (2002). Metallothionein: The Multipurpose Protein CMLS, Cell. Mol. Life Sci. 59, 627–647.
  • Dameron, C.T., Harrison M.D. (1998 suppl). Mechanisms for Protection against Copper Toxicity1–3 Am.j.Clin Nutr 67:1091S–7S.
  • Davis, S.R., Cousins, R.J. (2000). Metallothionein Expression in Animals: A Physiological Perspective on Function, J. Nutr. 130: 1085– 1088,
  • Deng, D.X., Cai, L., Chakrabarti, S., Cherian, M.G. (1999). Increased Radiation-induced Apoptosis in Mouse Thymus in the Absence of Metallothionein, Toxicology 134, 39–49.
  • Ebert, M.P.A., Gu¨ Nther T., Hoffmann , J., Yu, J., Miehlke, S., Schulz, H.U., Roessner, A., Korc, M., Malfertheiner, P. (2000). Expression of Metallothionein II in Intestinal Metaplasia, Dysplasia, and Gastric Cancer, Cancer Research 60, 1995–2001.
  • Fleet, J.C., Qureshi, M.A., Dietert, R.R., McCormick, C.C. (1988). Tissue- Specific Accumulation of Metallothionein in Chickens as Influenced by the Route of Zinc, J.Nutr. 118: 176–182.
  • El Ghazi, I. Martin, B. L., Armitage I.M.(2006). Metallothionein-3 Is a component of a Multiprotein Complex in the Mouse Brain. Exp. Biol. Med., 231,1500–1506.
  • Hahn, S.H., Yoo, O.J., Gahl, W.A. (2001). Effect of Metal Ions on the Stability of Metallothionein in the Degradation by Cellular Fractions in vitro Experimental and Molecular Medicine, 33, 32–36.
  • Hidalgo, J., Penkowa, M., Espejo, C., Marti´NezCa´ Ceres, E.M. Carrasco, J., Quintana, A., Molinero, A., Florit, S., Giralt, M., OrtegaAznar A. (2006). Expression of Metallothionein-I, -II, and –III in Alzheimer Disease and Animal Models of Neuroinflammation. Exp. Biol. Med., 231,1450–1458.
  • Horky, D., Lauschova, I., Illek, J., Pechova,A., Sindelar, M. (2002). Distribution of Exogenous Heavy Metals in the Hepatocytes of Calves: A Morphometric Study Microscopy Research And Technique 56, 451–453.
  • Kim, B.J., Kim, Y.H., Kim, S., Kim, J.W., Koh, J.Y., Oh, S.H., Lee, M.K., Kim, K.W., Lee, M.S. (2000). Zinc as a paracrine Effector in Pancreatic Islet Cell Death, Diabetes 49, 367–372.
  • Kojima, S., Shimada, A., Morita, T., Yamano, Y., Umemura, T (1999). Localization of Metallothioneins-I & -II and -III in the Brain of Aged Dog. J. Vet. Med. Sci. 61, 343–349.
  • McCormick, C.C. (1984). Induction and Accumulation of Metallothionein in Liver and Pancreas of Chicks Given Oral Zinc: A Tissue Comparison. J. Nutr. 114, 191–203.
  • Mocchegiani, E., Verbanac, D., Santarelli, L., Tibaldi, A., Muzzioli, M., Radosevic-Stasic, B., Milin, C. (1997). Zinc and Metallothioneins on Cellular Immune Effectiveness During Liver Regeneration in Young and Old Mice, Life Sciences 61, 1125–1145.
  • Margoshes, M, Vallee, B. (1957). A cadmium protein from equine kidney cortex. J Am. Chem. Soc. 79, 4813–4814.
  • Minami, T., Kubo, K., Ichida, S. (2002). Determination of Metallothionein-1 / Metallothionein-2 Ratios in the Mouse Liver and Pancreas by Capillary Zone Electrophoresis using a Polyacrylamidecoated Capillary at Neutral pH. Journal of Chromatography B, 779, 211–219.
  • Minami, T., Shimizu, M., Tanaka, H., Okazaki, Y., Cherian, M.G. (1999). Metallothionein does not Protect Mouse Endocrine Cells from Damage Induced by Alloxan. Injection Toxicology, 132, 33–41.
  • Onosaka, S., Tetsuchikawahara, N., Min, K-S. (2002). Paradigm Shift in Zinc: Metal Pathology. Tohoku J. Exp. Med. 196, 1–7.
  • Ohly, P., Dohle, C., Abel, J., Seissler, J., Gleichmann, H. (2000). Zinc Sulphate Induces Metallothionein in Pancreatic Islets of mice and Protects Against Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetologia, 43, 1020– 1030.
  • Philcox, J.C., Sturkenboom, M., Coyle P., Rofe, A.M. (2000). Metallothionein in Mice Reduces Intestinal Zinc Loss during Acute Endotoxin Inflammation, but Not during Starvation or Dietary Zinc Restriction. J. Nutr. 130, 1901–1909.
  • Sanz- Nebot, V., Andón, B., Barbosa, J.(2003). Characterization of metallothionein isoforms from rabbit liver by liquid chromatography coupled to electrospray mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.796, 379–393.
  • Solis-Heredia, M.J., Quintanilla-Vega, B., SierraSantoyo, A., Hernandez, J.M., Brambila, E., Cebrian, M.E., Albores, A. (2000). Chromium Increases Pancreatic Metallothionein in the Rat. Toxicology, 142, 111–117.
  • Sozmen, M., Erginsoy, Sd., Cenesiz, S., Devrim, A.K. (2005). The Protective Effect of Kefir and Vitamin C on Azoxymethane Induced Toxicity and Induction of Metallothionein in Mice. Scand. J. Lab. Anim. Sci. 32, 211– 220.
  • Sprietsma, J.E., Schuitemaker, G.E. (1994). Diabetes can be Prevented by Reducing Insulin Production, Med Hypotheses 42, 15– 23.
  • Swiergosz-Kowalewska, R. (2001). Cadmium Distribution and Toxicity in Tissues of Small Rodents. Microscopy Research and Technique 55, 208–222.
  • Tomita, T. (2000). Metallothionein in Pancreatic Endocrine Neoplasms. Mod. Pathol., 13, 389–395.
  • Tomita, T., Matsubara, O. (2000). Immunocytochemical Localization of Metallothionein in Human Pancreatic Islets. Pancreas, 20, 21–24.
  • Yang, J., Cherian, M.G. (1994). Protective Effects of Metallothionein on Streptozotocininduced Diabetes in Rats. Life Sci. 55, 43– 51.
  • Zambenedetti, P., Giordano, R., Zatta. P. (1998). Metallothioneins are Highly Expressed in Astrocytes and Microcapillaries in Alzheimer's Disease. Journal of Chemical Neuroanatomy 15 (1998) 21-60
  • Zhou, Z., Sun, X. and Kang, Y.J. (2002). Metallothionein Protection against Alcoholic Liver Injury through Inhibition of Oxidative Stres. Exp. Biol. Med., 227, 214–222.
There are 33 citations in total.

Details

Primary Language Turkish
Journal Section Derlemeler
Authors

Nejdet Şimşek This is me

Belma Alabay This is me

Publication Date March 31, 2010
Published in Issue Year 2007 Volume: 2 Issue: 2

Cite

APA Şimşek, N., & Alabay, B. (2010). Metallotiyoninlerin Histofizyolojik Önemi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 2(2), 75-81.
AMA Şimşek N, Alabay B. Metallotiyoninlerin Histofizyolojik Önemi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. March 2010;2(2):75-81.
Chicago Şimşek, Nejdet, and Belma Alabay. “Metallotiyoninlerin Histofizyolojik Önemi”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 2, no. 2 (March 2010): 75-81.
EndNote Şimşek N, Alabay B (March 1, 2010) Metallotiyoninlerin Histofizyolojik Önemi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 2 2 75–81.
IEEE N. Şimşek and B. Alabay, “Metallotiyoninlerin Histofizyolojik Önemi”, Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 2, no. 2, pp. 75–81, 2010.
ISNAD Şimşek, Nejdet - Alabay, Belma. “Metallotiyoninlerin Histofizyolojik Önemi”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 2/2 (March 2010), 75-81.
JAMA Şimşek N, Alabay B. Metallotiyoninlerin Histofizyolojik Önemi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2010;2:75–81.
MLA Şimşek, Nejdet and Belma Alabay. “Metallotiyoninlerin Histofizyolojik Önemi”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 2, no. 2, 2010, pp. 75-81.
Vancouver Şimşek N, Alabay B. Metallotiyoninlerin Histofizyolojik Önemi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2010;2(2):75-81.