İneklerde Nonsteroid Antiinflamatuar İlaçların Reprodüktif Amaçlı Kullanımı

Year 2018, Volume: 13 Issue: 1, 112 - 120, 25.04.2018

Hasan Alkan , Hüseyin Erdem

https://doi.org/10.17094/ataunivbd.289219

Cited By: 6

Abstract

Veteriner hekimlik alanında nonsteroid antiinflamatuar ilaçlar; ağrı kesici, ateş düşürücü ve yangı önleyici etkilerinden dolayı yaygın bir şekilde kullanılmaktadır. Bu etkilerini prostaglandinlerin sentezinden sorumlu siklooksijenaz (COX) enzimini inhibe ederek göstermektedirler. Prostaglandinler; çiftlik hayvanlarında ovaryum, uterus, plasenta ve hipofiz gibi reprodüktif açıdan önemli organlar üzerinde görevler almaktadırlar. Reprodüktif performans üzerine hem pozitif hem de negatif etki oluşturabilmektedirler. Prostaglandinlerin olumlu/olumsuz etkilerinin düzenlenmesinde en iyi seçenek nonsteroid antiinflamatuar ilaçlardır. Nonsteroid antiinflamatuar ilaçlar fertiliteyi artırmak amacıyla; suni tohumlama ve embriyo transferi sırası/sonrasında, repeat breder ineklerde uygulanabilmektedir. Aynı zamanda güç doğum olgularında, postpartum süreçte şekillenen retensiyo sekundinarum, akut septik metritis ve subklinik endometritis durumlarında da kullanılmaktadır. Sunulan derlemede, kullanımı giderek yaygınlaşan nonsteroid antiinflamatuar ilaçların reprodüktif performansı artırmak amacıyla uygulanması hakkında yeni bilgilerin sunulması amaçlanmıştır.

Keywords

Gebe kalma oranı, İnek, NSAID, Reprodüksiyon.

Reproductive Use of Nonsteroidal Antiinflammatory Drugs in Cows

Abstract

Nonsteroidal anti-inflammatory drugs is widely used in veterinary medicine due to their analgesic, antipyretic and anti-inflammatory effects. These effects are shown by inhibiting the enzyme cyclooxygenase (COX) responsible for the synthesis of prostaglandins. Prostaglandins are involved in many reproductive organs such as ovaries, uterus, placenta and pituitary gland. They can have both positive and negative effects on reproductive performance. The best choice is nonsteroidal anti-inflammatory drugs in the regulation of the positive/negative effects of the prostaglandins. Nonsteroidal anti-inflammatory drugs can be administered to repeat breeder cows in order to increase fertility, during/after artificial insemination and embryo transfer. It is also used in cases such as dystocia, postpartum period retentio secundinarium, acute septic metritis and subclinical endometritis. The aim of this review is to present new information about the applications of nonsteroid anti-inflammatory drugs, which are becoming increasingly widespread to improve reproductive performance.

Keywords

Conception rate, Cow, NSAID, Reproduction

References

• 1. Ong CKS., Lirk P., Tan CH., Seymour RA., 2007. An evidence-based update on nonsteroidal anti-inflammatory drugs. J Clin Med Res, 5 (1), 19-34.
• 2. Satılmış M., Bilgili A., 2013. Nonsteroid antiinflamatuvar ilaçların yeni kullanım seçenekleri. Erciyes Üniv Vet Fak Derg, 10 (1), 63-71.
• 3. Karademir Ü., Boyacıoğlu M., 2014. Nonsteroidal antiinflamatuvar ilaçların kedi ve köpeklerde etkili ve güvenli kullanımı. Erciyes Üniv Vet Fak Derg, 11 (2), 137-143.
• 4. Kim SJ., Flach AJ., Jampol LM., 2010. Nonsteroidal anti-inflammatory drugs in ophthalmology. Surv Ophthalmol, 55 (2), 108-133.
• 5. Praveen PN., Knaus EE., 2008. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDS): Cyclooxygenase (cox) inhibition and beyond. J Pharm Pharmaceut Sci, 11 (2), 81-110.
• 6. Frungieri MB., Calandra RS., Mayerhofer A., Matzkin ME., 2015. Cyclooxygenase and prostaglandins in somatic cell populations of the testis. Reproduction, 149 (4), 169-180.
• 7. Weems CW., Weems YS., Randel RD., 2006. Prostaglandins and reproduction in female farm animals. The Veterinary Journal, 171, 206–228.
• 8. Young CD, 2004. Reproductive efficiency following administration of an inhibitor of prostaglandin F2α during early embryonic development in dairy cattle. The University of Tennessee, Amerika Birleşik Devletleri.
• 9. Heuwieser W., Iwersen M., Goetze L., 2011. Efficacy of carprofen on conception rates in lactating dairy cows after subcutaneous or intrauterine administration at the time of breeding. J Dairy Sci, 94, 146–151.
• 10. Wann RA., Randel RD., 1990. Effect of uterine manipulation 35 days after parturition on plasma concentrations of 13, 14-dihydro-15-keto prostaglandin F2 α in multiparous and primiparous brahman cows. J Anim Sci, 68, 1389–1394.
• 11. Schallenberger E., Schams D., Meyer HH., 1989. Sequences of pituitary, ovarian and uterine hormone secretion during the first 5 weeks of pregnancy in dairy cattle. J Reprod Fertil, 37, 277-286.
• 12. Thatcher WW., Binelli M., Burke J., Staples CR., Ambrose JD., Coelho S., 1997. Antiluteolytic signals between the conceptus and endometrium. Theriogenology, 47, 131-140.
• 13. Binelli M., Thatcher WW., Matto R., Baruselli PS., 2001. Antiluteolytic strategies to improve fertility in cattle. Theriogenology 56, 1451-1463.
• 14. Güzeloğlu A., Erdem H., Saribay MK., Thatcher WW., Tekeli T., 2007. Effect of the administration of flunixin meglumine on pregnancy rates in Holstein heifers. Vet Rec, 160, 404-406.
• 15. Erdem H., Güzeloğlu A., 2010. Effect of meloxicam treatment during early pregnancy in holstein heifers. Reprod Dom Anim 45, 625–628.
• 16. Emre B., Zonturlu AK., Korkmaz Ö., 2012. Sütçü ineklerde ovsynch protokolünü takiben uygulanan fluniksin meglumin’in gebelik oranı üzerine etkisi. Harran Üniv Vet Fak Derg, 1 (2), 88-91.
• 17. von Krueger X., Heuwieser W., 2010. Effect of flunixin meglumine and carprofen on pregnancy rates in dairy cattle. J Dairy Sci, 93, 5140–5146.
• 18. Hasler JF., 2014. Forty years of embryo transfer in cattle: A review focusing on the journal Theriogenology, the growth of the industry in North America, and personal reminisces. Theriogenology, 81, 152-169.
• 19. Galli C., Duchi R., Crotti G., Turini P., Ponderato N., Colleoni S., Lagutina I., Lazzari G., 2003. Bovine embryo technologies. Theriogenology, 59, 599-616.
• 20. McNaughtan JW., 2004. The effect of prostaglandin inhibitor on pregnancy rates of heifer embryo transfer recipients. Department of Plant & Animal Sciences, Brigham Young University, İngiltere.
• 21. Elli M., Gaffuri B., Frigerio A., Zanardelli M., Covini D., Candiani M., Vignali M., 2001. Effect of a single dose of ibuprofen lysinate before embryo transfer on pregnancy rates in cows. Reproduction, 121, 151–154.
• 22. Bülbül B., Dursun Ş., Kırbaş M., Köse M., Ümütlü S., 2010. Düvelerde embriyo transferi öncesi flunixin meglumin uygulamasının gebelik oranı üzerine etkisi. Kafkas Univ Vet Fak Derg, 16(1), 105-109.
• 23. Scenna FN., 2006. Inhibition of direct prostaglandin F2α effects on pre-attachment embryos improves reproductive efficiency in cattle. University of Tennessee, Knoxville.
• 24. Aguiar TS., Araujo CV., Tirloni RR., Martins LR., 2013. Effect of meloxicam on pregnancy rate of recipient heifers following transfer of in vitro produced embryos. Reprod Dom Anim, 48, 984–988.
• 25. Lopes LMJ., Balbinot M., Fonseca BA., Araújo CV., Martins LR., 2015. Pregnancy rates and serum 13,14-dihydro-15-keto-PGF2 alpha concentrations inrecipient Nelore heifers treated with meloxicam following the transfer of in vitro produced embryos. Theriogenology, 84, 553-558.
• 26. Doğruer G., Sarıbay MK., Karaca F., 2007. Repeat breeder sorunlu düvelerde fluniksin meglumin uygulamalarının gebelik oranı üzerine etkisi. FÜ Sağ Bil Derg, 21 (6), 263-268.
• 27. Sarvi F., Farzaneh N., Kasravi R., Seifi HA., 2013. Comparison between the effects of meloxicam and flunixin meglumine on pregnancy per artificial insemination in repeat breeder dairy cows. 2nd International Congress of Large Animal Practitioners, İran.
• 28. Amiridis GS., Tsiligianni T., Dovolou E., Rekkas C., Vouzaras D., Menegatos I., 2009. Combined administration of gonadotropin-releasing hormone, progesterone, and meloxicam is an effective treatment forth repeat-breeder cow. Theriogenology, 72, 542–548.
• 29. Laven R., Chambers P., Stafford K., 2012. Using non-steroidal anti-inflammatory drugs around calving: maximizing comfort, productivity and fertility. Vet J, 192 (1), 8-12.
• 30. Huxley JN., Whay HR., 2006. Current attitudes of cattle practitioners to pain and the use of analgesics in cattle. Vet Rec, 159, 662-668.
• 31. Huxley JN., HR Whay HR., 2007. Attitudes of UK veterinary surgeons and cattle farmers to pain and the use of analgesics in cattle. Cattle Pract, 15, 189–193.
• 32. Duffield TF., Dingwell HP., Weary D., Skidmore A., Neuder L., Raphael W., Millman S., Newby N., Leslie KE., 2009. Effect of flunixin meglumine treatment following parturition on cow health and milk production. J Dairy Sci Vol 92, E-Suppl. 1.
• 33. Richards BD., Black DH., Christley RM., Royal MD., Smith RF., Dobson H., 2009. Effects of the administration of ketoprofen at parturition on the milk yield and fertility of Holstein-Friesian cattle. Vet Rec, 165, 102-106.
• 34. Sheldon IM., Lewis GS., LeBlanc S., Gilbert RO., 2006. Defining postpartum uterine disease in cattle. Theriogenology, 65 (8), 1516-1530.
• 35. Földi J., Kulcsar M., Pecsi A., Huyghe B., de Sa C., Lohuis JACM., Cox P., Huszenicza G., 2006. Bacterial complications of postpartum uterineinvolution in cattle. Anim Reprod Sci, 96, 265-281.
• 36. Drillich M., Voigt D., Forderung D., Heuwieser W., 2007. Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment. J Dairy Sci, 90 (8), 3758-3763.
• 37. Amiridis GS., Leontides AL., Tassos E., Kostoulas P., Fthenakis GC., 2001. Flunixin meglumine accelerates uterine involution and shortens the calving-to-first-oestrus interval in cows with puerperal metritis. J Vet Pharmacol Therap, 24, 365-367.
• 38. Priest N., 2013. The effect of a non-steroidal anti-inflammatorydrug on subclinical endometritis in dairy cows and the identification of at-risk cows. Lincoln University, United Kingdom.
• 39. Tek Ç., Sabuncu A., İkiz S., Bağcıgil F., Gündüz MC., Kılıçarslan MR., Özgür Y., 2010. The effect of a single administration of parenteral oxytetracycline and flunixin meglumine combination onthe reproductive performance of dairy cows withsubclinical endometritis. Turk J Vet Anim Sci, 34 (4), 319-325.
• 40. Poustchi MS., Mosaferi S., 2015. Comparative study of general injectıon and intra uterine transfusion of flunixin meglumine in the treatment of cows with endometritis. IJBPAS, 4 (5), 2732-2737.