Novel Chaphamaparvovirus in a Paradise Tanager Songbird with Encephalitis, Neuritis, and Ventriculitis

Year 2021, Volume: 16 Issue: 1, 25 - 31, 26.04.2021

Eda Altan , Steven Kubiski Ilse Stalis Yanpeng Li Xutao Deng Eric Delwart

Abstract

Parvoviridae family being an extremely fast-growing family and is open to novel viral discoveries. Many new parvoviruses from different vertebrates and invertebrates hosts have been discovered in recent years. The taxonomy has changed with new classification by the International Committee on Taxonomy of Viruses. The subfamily Hamaparvovirinae has been added to the prior subfamilies that consisted of Parvovirinae and Densovirinae. Chaphamaparvovirus is a recently identified genus of Hamaparvovirinae, including some members associated with nephropathy in laboratory mice and high mortality in Tilapia fish. Samples from a deceased Northern paradise tanager (Tangara chilensis paradisea) with nonsuppurative encephalitis, neuritis, and ventriculitis were examined by light microscopy and ancillary histochemical stains for bacteria, protozoa, fungi, and other parasites. Samples were also analyzed by PCR for general protozoa, paramyxovirus, avian bornavirus, and herpesvirus. None of these known pathogens were detected. Using viral metagenomics we identified and characterized the genome of a novel chaphamaparvovirus in tissues of this bird. No other viral sequences were identified. This virus’s contributory role to these lesions will require further studies.

Keywords

Chaphamaparvovirus, chufflevirus, metagenomics, parvovirus, Tangara chilensis paradisea

Supporting Institution

Vitalant Research Institute and San Diego Zoo Global

Ensefalit, Neurit ve Ventrikülit’li Paradise Tanager Ötücü Kuşunda Yeni Chaphamaparvovirus

Abstract

Parvoviridae ailesi son derece hızlı büyüyen bir ailedir ve yeni virus keşiflerine açıktır. Son yıllarda bu aileye ait farklı omurgalılardan ve omurgasızlardan birçok yeni virus keşfedilmiştir. Yapılan yeni keşiflerle Uluslararası Virus Taksonomisi Komitesi tarafından taksonomi değiştirilmiştir. Daha önce Parvovirinae ve Densovirinae olan alt ailelere Hamaparvovirinae alt ailesi eklenmiştir. Chaphamaparvovirus, yakın zamanda tanımlanan bir parvovirus genusudur (Parvoviridae ailesi) bazı alt türleri laboratuvar farelerinde nefropati ile ilişkili ve Tilapya balıklarında yüksek ölüm oranı göstermektedir. Ensefalit, nörit ve ventrikülitli bulguları ile ölen bir Cennet Tangarası (Tangara chilensis paradisea) kuşundan alınan numuneler, ışık mikroskobu ve bakteriyolojik, protozoer, mantar, ve diğer paraziter etkenler yönünden histokimyasal olarak incelendi. Örnekler ayrıca genel protozoa, paramiksovirus, avian bornavirus ve herpesvirus için PCR ile analiz yapıldı ve bulaşıcı ajan tespit edilmedi. Yeni nesil sekanslama methodu ile viral metagenomik kullanarak, bu kuşun dokularındaki yeni bir chaphamaparvovirus genomunu karakterize edildi Herhangi başka hiçbir viral sekans (etken) tanımlanmadı. Bu çalışma yeni bir virus keşif yayını olup bu virusun bu lezyonlara katkıda bulunan rolünün doğrulanması için öncü nitelikte olacaktır.

Keywords

Cennet tangası kuşu, Chaphamaparvovirus, Chufflevirus, Metagenomics, Parvovirus

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