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Dogo Argentino Irkı Yavru Köpeklerde Izofluran ve Sevofluran'ın BAER ve Timpanometre Üzerindeki Etkilerinin Karşılaştırılması

Year 2021, Volume: 16 Issue: 1, 63 - 72, 26.04.2021

Abstract

İzofluran ve sevofluran, veteriner pratiğinde en sık kullanılan uçucu anestezik ajanlardır ancak beyin üzerindeki etkileri tam olarak anlaşılamamıştır. Bu çalışmada, stabil genel anestezi dönemlerinde kaydedilen beyin sapı işitsel uyarılmış yanıt (BAER) testi verilerinin sevofluran (%1.7) ve izofluranın (%2.1) spesifik MAK (Minimal Alveolar Konsantrasyon) değerlerinde karşılaştırılması amaçlanmıştır. Fiziki, video-otoskopik ve timpanometrik muayene sonuçlarına göre sağlıklı olarak değerlendirilen hastalar çalışmaya dahil edildi. Böylece detaylı ırka özgü referans timpanometrik değerler belirli yaş aralığında elde edildi. Çalışmada izofluran (n: 6) ve sevofluran (n: 6) ile anestezisi idame ettirilen 8-12 haftalık, 12 (9 erkek ve 3 dişi) Dogo Argentino ırkı köpek kullanıldı. Timpanometri verilerinin yanı sıra, BAER kayıtları iki grup arasındaki latans, amplitüd, V/I amplitüd oranı ve interpik latansları karşılaştırıldı. Veriler Student's t testi kullanılarak incelendi. İstatistiksel anlamlılık P<0.05 olarak belirlendi. Çalışma tasarımı prospektif, klinik, kör, çapraz çalışmadır. Sonuç olarak, izofluran grubunda bu çalışmada belirlenen MAK değerleri için beyin daha baskılanmış görünmektedir ancak timpanometri değerleri etkilenmemiştir.

References

  • 1. Aksenov DP., Miller MJ., Dixon CJ., Wyrwicz AM., 2019. The effect of sevoflurane and isoflurane anesthesia on single unit and local field potentials. Exp Brain Res, 237, 1521-1529.
  • 2. Sonner JM., Cantor RS., 2013. Molecular mechanisms of drug action: an emerging view. Annu Rev Biophys, 42, 143-167.
  • 3. Beaumont H., Jönsson-Rylander A-C., Carlsson K., Pierrou S., Ahlefelt M., Branden L., Jensen J., Boeckxstaens GE., Lehmann A., 2008. The role of GABA(A) receptors in the control of transient lower oesophageal sphincter relaxations in the dog. Br J Pharmacol, 153, 1195-1202.
  • 4. Reed R., Doherty T., 2018. Minimum alveolar concentration: Key concepts and a review of its pharmacological reduction in dogs. Res Vet Sci, 117, 266-270.
  • 5. Scheifele PM., Clark JG., 2012.Electrodiagnostic evaluation of auditory function in the dog. Vet Clin North Am Small Anim Pract, 42, 1241-1257.
  • 6. Armaşu M., Musteata M., Stanciu GD., Mocanu D., Solcan G., 2015. Brainstem auditory evoked responses in healthy Argentine Mastiffdogs recorded with surface electrodes. Arq Bras Med Vet e Zootec, 67, 1457-1460.
  • 7. Radlinsky MG., 2016. Advances in Otoscopy. Vet Clin North Am Small Anim Pract, 46, 171-179.
  • 8. Jerger J., 1970. Clinical experience with impedance audiometry. Arch Otolaryngol, 92, 311-324.
  • 9. Schilder AGM., Chonmaitree T., Cripps AW., Rosenfeld RM., Casselbrant ML., Haggard MP., Venekamp RP., 2016. Otitis media. Nat Rev Dis Prim, 2, 16063.
  • 10. Ros C., Soler C., Mateo AGC., 2017. Comparison of the brainstem auditory evoked responses during sevoflurane or alfaxalone anaesthesia in adult cats. Vet Anaesth Analg, 44, 1085-1090.
  • 11. Hayward JJ., Kelly-Smith M., Boyko AR., Burmeister L., De Risio D., Mellers C., Freeman J., Strain GM., 2020. A genome-wide association study of deafness in three canine breeds. Plos One, 15, e0232900.
  • 12. Strain GM., 2021. Congenital sensorineural deafness in Dogo Argentino dogs: Prevalence and phenotype associations. Vet Rec., e299.
  • 13. Coppens AG., Steinberg SA., Poncelet L., 2003. Inner ear morphology in a bilaterally deaf Dogo Argentino pup. J Comp Pathol, 128, 67-70.
  • 14. Płonek M., Giza E., Niedzwiedz A., Kubiak K., Nicpon J., Wrzosek M., 2016. Evaluation of the occurrence of canine congenital sensorineural deafness in puppies of predisposed dog breeds using the brainstem auditory evoked response. Acta Vet Hung, 64, 425-435.
  • 15. Şengöz Şirin Ö., Şirin YS., Beşalti Ö., 2018. Does acoustic trauma occur in pointers due to firearm noise? A prospective study on 50 hunting dogs. Ankara Univ Vet Fak Derg, 65, 365-372.
  • 16. Angus JC., Campbell KL., 2001. Uses and indications for video-otoscopy in small animal practice. Vet Clin North Am Small Anim Pract, 31, 809-828.
  • 17. Gotthelf LN., 2005. Small Animal Ear Diseases: An Illustrated Guide 2nd edn., 60-64, Elsevier Saunders, Missouri.
  • 18. Fiellau-Nikolajsen M., 1983. Tympanometric prediction of the magnitude of hearing loss in preschool-children with secretory otitis media. Scand Audiol Suppl, 17, 68-72.
  • 19. Strain GM., 2015. The genetics of deafness in domestic animals. Front Vet Sci, 2, 1-20.
  • 20. Stenklev NC., Vik O., Laukli E., 2004. The aging ear: An otomicroscopic and tympanometric study. Acta Otolaryngol, 124, 69-76.
  • 21. Camboim E., Scharlach R., Almeida M., Vasconcelos D., Azevedo M., 2012. Analysis of compliance and tympanometric gradient in infants with reflux. Rev da Soc Bras Fonoaudiol, 1, 156-160.
  • 22. Duzer S., Sakallioglu O., Akyigit A., Polat C., Cetiner H., Susaman N., 2017. Values range of tympanometric gradient in otitis media with effusion. J Craniofac Surg, 28, e283-e286.
  • 23. Hunter LL., Sanford CA., 2014. Tympanometry and Wideband Acoustic Immitance. In " Handbook of Clinical Audiology", Ed., Katz J., 7th edn., 137-163, Wolters Kluwer, New York.
  • 24. Cole LK., Podell M., Kwochka KW., 2000. Impedance audiometric measurements in clinically normal dogs. Am J Vet Res, 61, 87-92.
  • 25. Borges LR., Donadon C., Sanfins MD., Valente JP., Paschoal JR., Colella-Santos MF., 2020. The effects of otitis media with effusion on the measurement of auditory evoked potentials. Int J Pediatr Otorhinolaryngol, 133, 109978.
  • 26. Wilson WJ., Mills PC., 2005. Brainstem auditory-evoked response in dogs. Am J Vet Res, 66, 2177-2187.
  • 27. Norrix LW., Trepanier S., Atlas M., Kim D., 2012. The auditory brainstem response: Latencies obtained in children while under general anesthesia. J Am Acad Audiol, 23, 57-63.
  • 28. Bielefeld EC., 2014. Influence of dose and duration of isoflurane anesthesia on the auditory brainstem response in the rat. Int J Audiol, 53, 250-258.
  • 29. Dewey CW., Costa RC., Ducote JM., 2016. Neurodiagnostics. In "Practical guide to canine an feline neurology", Eds., Dewey CW., Costa RC., 3rd edn., 61-86, Wiley Blackwell, Iowa.

Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies

Year 2021, Volume: 16 Issue: 1, 63 - 72, 26.04.2021

Abstract

Isoflurane and sevoflurane are the most frequently used volatile anesthetic agents in veterinary practice yet their effects on the brain are not fully understood. In this study, it was aimed to compare the brainstem auditory evoked response (BAER) test data recorded during stable general anesthesia periods in specific MAC (Minimal Alveolar Concentration) values of sevoflurane (1.7%) and isoflurane (2.1%). The patients who were evaluated as healthy according to physical, video-otoscopy, and tympanometry examination results were included in the study. Thus, detailed breed specific reference tympanometric values were obtained in a certain age range. In the study, 12 (9 male and 3 female) Dogo Argentino breed, 8-12 weeks old, healthy dogs were used, which were maintained with anesthesia with isoflurane (n: 6) and sevoflurane (n: 6). As well as tympanometry data, the latency, amplitude, V/I amplitude ratio, and interpeak latencies between the two groups BAER records were compared. Data were analyzed using Student's t-test. Statistical significance was determined as P<0.05. The study design is prospective, clinical, blind, cross-study. In conclusion, the brain appears to be more suppressed for the minimal alveolar concentration values determined in this study in the isoflurane group, but tympanometry values were not affected.

References

  • 1. Aksenov DP., Miller MJ., Dixon CJ., Wyrwicz AM., 2019. The effect of sevoflurane and isoflurane anesthesia on single unit and local field potentials. Exp Brain Res, 237, 1521-1529.
  • 2. Sonner JM., Cantor RS., 2013. Molecular mechanisms of drug action: an emerging view. Annu Rev Biophys, 42, 143-167.
  • 3. Beaumont H., Jönsson-Rylander A-C., Carlsson K., Pierrou S., Ahlefelt M., Branden L., Jensen J., Boeckxstaens GE., Lehmann A., 2008. The role of GABA(A) receptors in the control of transient lower oesophageal sphincter relaxations in the dog. Br J Pharmacol, 153, 1195-1202.
  • 4. Reed R., Doherty T., 2018. Minimum alveolar concentration: Key concepts and a review of its pharmacological reduction in dogs. Res Vet Sci, 117, 266-270.
  • 5. Scheifele PM., Clark JG., 2012.Electrodiagnostic evaluation of auditory function in the dog. Vet Clin North Am Small Anim Pract, 42, 1241-1257.
  • 6. Armaşu M., Musteata M., Stanciu GD., Mocanu D., Solcan G., 2015. Brainstem auditory evoked responses in healthy Argentine Mastiffdogs recorded with surface electrodes. Arq Bras Med Vet e Zootec, 67, 1457-1460.
  • 7. Radlinsky MG., 2016. Advances in Otoscopy. Vet Clin North Am Small Anim Pract, 46, 171-179.
  • 8. Jerger J., 1970. Clinical experience with impedance audiometry. Arch Otolaryngol, 92, 311-324.
  • 9. Schilder AGM., Chonmaitree T., Cripps AW., Rosenfeld RM., Casselbrant ML., Haggard MP., Venekamp RP., 2016. Otitis media. Nat Rev Dis Prim, 2, 16063.
  • 10. Ros C., Soler C., Mateo AGC., 2017. Comparison of the brainstem auditory evoked responses during sevoflurane or alfaxalone anaesthesia in adult cats. Vet Anaesth Analg, 44, 1085-1090.
  • 11. Hayward JJ., Kelly-Smith M., Boyko AR., Burmeister L., De Risio D., Mellers C., Freeman J., Strain GM., 2020. A genome-wide association study of deafness in three canine breeds. Plos One, 15, e0232900.
  • 12. Strain GM., 2021. Congenital sensorineural deafness in Dogo Argentino dogs: Prevalence and phenotype associations. Vet Rec., e299.
  • 13. Coppens AG., Steinberg SA., Poncelet L., 2003. Inner ear morphology in a bilaterally deaf Dogo Argentino pup. J Comp Pathol, 128, 67-70.
  • 14. Płonek M., Giza E., Niedzwiedz A., Kubiak K., Nicpon J., Wrzosek M., 2016. Evaluation of the occurrence of canine congenital sensorineural deafness in puppies of predisposed dog breeds using the brainstem auditory evoked response. Acta Vet Hung, 64, 425-435.
  • 15. Şengöz Şirin Ö., Şirin YS., Beşalti Ö., 2018. Does acoustic trauma occur in pointers due to firearm noise? A prospective study on 50 hunting dogs. Ankara Univ Vet Fak Derg, 65, 365-372.
  • 16. Angus JC., Campbell KL., 2001. Uses and indications for video-otoscopy in small animal practice. Vet Clin North Am Small Anim Pract, 31, 809-828.
  • 17. Gotthelf LN., 2005. Small Animal Ear Diseases: An Illustrated Guide 2nd edn., 60-64, Elsevier Saunders, Missouri.
  • 18. Fiellau-Nikolajsen M., 1983. Tympanometric prediction of the magnitude of hearing loss in preschool-children with secretory otitis media. Scand Audiol Suppl, 17, 68-72.
  • 19. Strain GM., 2015. The genetics of deafness in domestic animals. Front Vet Sci, 2, 1-20.
  • 20. Stenklev NC., Vik O., Laukli E., 2004. The aging ear: An otomicroscopic and tympanometric study. Acta Otolaryngol, 124, 69-76.
  • 21. Camboim E., Scharlach R., Almeida M., Vasconcelos D., Azevedo M., 2012. Analysis of compliance and tympanometric gradient in infants with reflux. Rev da Soc Bras Fonoaudiol, 1, 156-160.
  • 22. Duzer S., Sakallioglu O., Akyigit A., Polat C., Cetiner H., Susaman N., 2017. Values range of tympanometric gradient in otitis media with effusion. J Craniofac Surg, 28, e283-e286.
  • 23. Hunter LL., Sanford CA., 2014. Tympanometry and Wideband Acoustic Immitance. In " Handbook of Clinical Audiology", Ed., Katz J., 7th edn., 137-163, Wolters Kluwer, New York.
  • 24. Cole LK., Podell M., Kwochka KW., 2000. Impedance audiometric measurements in clinically normal dogs. Am J Vet Res, 61, 87-92.
  • 25. Borges LR., Donadon C., Sanfins MD., Valente JP., Paschoal JR., Colella-Santos MF., 2020. The effects of otitis media with effusion on the measurement of auditory evoked potentials. Int J Pediatr Otorhinolaryngol, 133, 109978.
  • 26. Wilson WJ., Mills PC., 2005. Brainstem auditory-evoked response in dogs. Am J Vet Res, 66, 2177-2187.
  • 27. Norrix LW., Trepanier S., Atlas M., Kim D., 2012. The auditory brainstem response: Latencies obtained in children while under general anesthesia. J Am Acad Audiol, 23, 57-63.
  • 28. Bielefeld EC., 2014. Influence of dose and duration of isoflurane anesthesia on the auditory brainstem response in the rat. Int J Audiol, 53, 250-258.
  • 29. Dewey CW., Costa RC., Ducote JM., 2016. Neurodiagnostics. In "Practical guide to canine an feline neurology", Eds., Dewey CW., Costa RC., 3rd edn., 61-86, Wiley Blackwell, Iowa.
There are 29 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Araştırma Makaleleri
Authors

Yusuf Sinan Şirin This is me

Özlem Şengöz Şirin This is me

Harun Çınar This is me

Publication Date April 26, 2021
Published in Issue Year 2021 Volume: 16 Issue: 1

Cite

APA Şirin, Y. S., Şengöz Şirin, Ö., & Çınar, H. (2021). Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 16(1), 63-72.
AMA Şirin YS, Şengöz Şirin Ö, Çınar H. Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. April 2021;16(1):63-72.
Chicago Şirin, Yusuf Sinan, Özlem Şengöz Şirin, and Harun Çınar. “Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 16, no. 1 (April 2021): 63-72.
EndNote Şirin YS, Şengöz Şirin Ö, Çınar H (April 1, 2021) Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 16 1 63–72.
IEEE Y. S. Şirin, Ö. Şengöz Şirin, and H. Çınar, “Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies”, Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 16, no. 1, pp. 63–72, 2021.
ISNAD Şirin, Yusuf Sinan et al. “Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 16/1 (April 2021), 63-72.
JAMA Şirin YS, Şengöz Şirin Ö, Çınar H. Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2021;16:63–72.
MLA Şirin, Yusuf Sinan et al. “Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 16, no. 1, 2021, pp. 63-72.
Vancouver Şirin YS, Şengöz Şirin Ö, Çınar H. Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2021;16(1):63-72.