A RARE COEXISTENCE: CELIAC DISEASE AND ULCERATIVE COLITIS

Abstract

Celiac Disease (CD) is a chronic autoimmune enteropathy that affests all systems, although it mostly affects the small intestine. In Ulcerative colitis (UC), which is an Inflammatory Bowel Disease (IBD), there is recurrent immune activation and inflammation of the gastrointestinal system. According to the literature, the coexistence of CD and UK was found to be infrequent. In this article, we present a young female patient with CD who developed UC.

Keywords

• CELIAC DISEASE
• ULCERATIVE COLITIS
• Inflammatory Bowel Disease

Nadir Bir Birliktelik: Çölyak Hastalığı ve Ülseratif Kolit

Abstract

Çölyak hastalığı (ÇH) daha çok ince barsağı etkilemekle birlikte tüm sistemleri etkileyen kronik otoimmün bir enteropatidir. İnflamatuar barsak hastalığı (İBH) olan ülseratif kolitte (ÜK) ise gastrointestinal sistemin tekrarlayan immun aktivasyonu ve inflamasyonu vardır. Literatüre göre ÇH-ÜK birlikteliğinin sık olmadığı saptanmıştır. Bu makalede ÇH tanısı olan hastada ÜK gelişen genç bir kadın hasta sunulmuştur.

Keywords

• ÇÖLYAK HASTALIĞI
• ÜLSERATİF KOLİT
• İnflamatuar barsak hastalığı

References

1. Catassi, C., Verdu, E. F., Bai, J. C., & Lionetti, E. (2022). Coeliac disease. Lancet (London, England), 399(10344), 2413– 2426.
2. Malamut, G., Soderquist, C. R., Bhagat, G., & Cerf-Bensussan, N. (2024). Advances in Nonresponsive and Refractory Celiac Disease. Gastroenterology, 167(1), 132–147.
3. Rubio-Tapia, A., Hill, I. D., Kelly, C. P., Calderwood, A. H., Murray, J. A., & American College of Gastroenterology (2013). ACG clinical guidelines: diagnosis and management of celiac disease. The American journal of gastroenterology, 108(5), 656–677.
4. Ludvigsson, J. F., Bai, J. C., Biagi, F., Card, T. R., Ciacci, C., Ciclitira, P. J., Green, P. H., Hadjivassiliou, M., Holdoway, A., van Heel, D. A., Kaukinen, K., Leffler, D. A., Leonard, J. N., Lundin, K. E., McGough, N., Davidson, M., Murray, J. A., Swift, G. L., Walker, M. M., Zingone, F., … British Society of Gastroenterology (2014). Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut, 63(8), 1210–1228.
5. Kaplan G. G. (2015). The global burden of IBD: from 2015 to 2025. Nature reviews. Gastroenterology & hepatology, 12(12), 720–727.
6. Assa, A., Frenkel-Nir, Y., Tzur, D., Katz, L. H., & Shamir, R. (2017). Large population study shows that adolescents with celiac disease have an increased risk of multiple autoimmune and nonautoimmune comorbidities. Acta paediatrica (Oslo, Norway : 1992), 106(6), 967–972.
7. Ghersin, I., Khateeb, N., Katz, L. H., Daher, S., Shamir, R., & Assa, A. (2020). Comorbidities in adolescents with inflammatory bowel disease: findings from a population- based cohort study. Pediatric research, 87(7), 1256–1262.
8. Pinto-Sanchez, M. I., Verdu, E. F., Gordillo, M. C., Bai, J. C., Birch, S., Moayyedi, P., & Bercik, P. (2015). Tax-deductible provisions for gluten-free diet in Canada compared with systems for gluten-free diet coverage available in various countries. Canadian journal of gastroenterology & hepatology, 29(2), 104–110.

9. Oxford, E. C., Nguyen, D. D., Sauk, J., Korzenik, J. R., Yajnik, V., Friedman, S., & Ananthakrishnan, A. N. (2013). Impact of coexistent celiac disease on phenotype and natural history of inflammatory bowel diseases. The American journal of gastroenterology, 108(7), 1123–1129.
10. Braun, T., Sosnovski, K. E., Amir, A., BenShoshan, M., VanDussen, K. L., Karns, R., Levhar, N., Abbas-Egbariya, H., Hadar, R., Efroni, G., Castel, D., Avivi, C., Rosen, M. J., Grifiths, A. M., Walters, T. D., Mack, D. R., Boyle, B. M., Ali, S. A., Moore, S. R., Schirmer, M., … Haberman, Y. (2023). Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn’s disease, and celiac disease. JCI insight, 8(14), e170181.
11. Shah, A., Walker, M., Burger, D., Martin, N., von Wulffen, M., Koloski, N., Jones, M., Talley, N. J., & Holtmann, G. J. (2019). Link Between Celiac Disease and Inflammatory Bowel Disease. Journal of clinical gastroenterology, 53(7), 514–522.
12. Leeds, J. S., Höroldt, B. S., Sidhu, R., Hopper, A. D., Robinson, K., Toulson, B., Dixon, L., Lobo, A. J., McAlindon, M. E., Hurlstone, D. P., & Sanders, D. S. (2007). Is there an association between coeliac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls. Scandinavian journal of gastroenterology, 42(10), 1214–1220.
13. Pinto-Sanchez, M. I., Seiler, C. L., Santesso, N., Alaedini, A., Semrad, C., Lee, A. R., Bercik, P., Lebwohl, B., Leffler, D. A., Kelly, C. P., Moayyedi, P., Green, P. H., & Verdu, E. F. (2020). Association Between Inflammatory Bowel Diseases and Celiac Disease: A Systematic Review and Meta- Analysis. Gastroenterology, 159(3), 884–903.e31.
14. Casella, G., D’Incà, R., Oliva, L., Daperno, M., Saladino, V., Zoli, G., Annese, V., Fries, W., Cortellezzi, C., & Italian Group - IBD (2010). Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 42(3), 175–178.