A RARE COEXISTENCE: CELIAC DISEASE AND ULCERATIVE COLITIS
Year 2026,
Volume: 9 Issue: 1, 15 - 18, 16.03.2026
Ahmet Uyanıkoğlu
,
Serpil Uyanikoğlu
,
Dursun Çadırcı Barut
Abstract
Celiac Disease (CD) is a chronic autoimmune enteropathy that affests all systems, although it mostly affects the small intestine. In Ulcerative colitis (UC), which is an Inflammatory Bowel Disease (IBD), there is recurrent immune activation and inflammation of the gastrointestinal system. According to the literature, the coexistence of CD and UK was found to be infrequent. In this article, we present a young female patient with CD who developed UC.
References
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Catassi, C., Verdu, E. F., Bai, J. C., & Lionetti,
E. (2022). Coeliac disease. Lancet
(London, England), 399(10344), 2413–
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Malamut, G., Soderquist, C. R., Bhagat, G.,
& Cerf-Bensussan, N. (2024). Advances in
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Gastroenterology, 167(1), 132–147.
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Calderwood, A. H., Murray, J. A., & American
College of Gastroenterology (2013).
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management of celiac disease. The American
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T. R., Ciacci, C., Ciclitira, P. J., Green, P.
H., Hadjivassiliou, M., Holdoway, A., van
Heel, D. A., Kaukinen, K., Leffler, D. A.,
Leonard, J. N., Lundin, K. E., McGough,
N., Davidson, M., Murray, J. A., Swift, G.
L., Walker, M. M., Zingone, F., … British
Society of Gastroenterology (2014).
Diagnosis and management of adult coeliac
disease: guidelines from the British
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IBD: from 2015 to 2025. Nature reviews.
Gastroenterology & hepatology, 12(12),
720–727.
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Assa, A., Frenkel-Nir, Y., Tzur, D., Katz, L.
H., & Shamir, R. (2017). Large population
study shows that adolescents with celiac
disease have an increased risk of multiple
autoimmune and nonautoimmune comorbidities.
Acta paediatrica (Oslo, Norway :
1992), 106(6), 967–972.
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Ghersin, I., Khateeb, N., Katz, L. H., Daher,
S., Shamir, R., & Assa, A. (2020).
Comorbidities in adolescents with inflammatory
bowel disease: findings from a population-
based cohort study. Pediatric research,
87(7), 1256–1262.
-
Pinto-Sanchez, M. I., Verdu, E. F., Gordillo,
M. C., Bai, J. C., Birch, S., Moayyedi,
P., & Bercik, P. (2015). Tax-deductible
provisions for gluten-free diet in Canada
compared with systems for gluten-free diet coverage available in various countries.
Canadian journal of gastroenterology
& hepatology, 29(2), 104–110.
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Oxford, E. C., Nguyen, D. D., Sauk, J.,
Korzenik, J. R., Yajnik, V., Friedman, S.,
& Ananthakrishnan, A. N. (2013). Impact
of coexistent celiac disease on phenotype
and natural history of inflammatory bowel
diseases. The American journal of gastroenterology,
108(7), 1123–1129.
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Braun, T., Sosnovski, K. E., Amir, A.,
BenShoshan, M., VanDussen, K. L., Karns,
R., Levhar, N., Abbas-Egbariya, H.,
Hadar, R., Efroni, G., Castel, D., Avivi, C.,
Rosen, M. J., Grifiths, A. M., Walters, T.
D., Mack, D. R., Boyle, B. M., Ali, S. A.,
Moore, S. R., Schirmer, M., … Haberman,
Y. (2023). Mucosal transcriptomics highlight
lncRNAs implicated in ulcerative colitis,
Crohn’s disease, and celiac disease. JCI
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-
Shah, A., Walker, M., Burger, D., Martin,
N., von Wulffen, M., Koloski, N., Jones,
M., Talley, N. J., & Holtmann, G. J. (2019).
Link Between Celiac Disease and Inflammatory
Bowel Disease. Journal of clinical
gastroenterology, 53(7), 514–522.
-
Leeds, J. S., Höroldt, B. S., Sidhu, R.,
Hopper, A. D., Robinson, K., Toulson, B.,
Dixon, L., Lobo, A. J., McAlindon, M. E.,
Hurlstone, D. P., & Sanders, D. S. (2007).
Is there an association between coeliac disease
and inflammatory bowel diseases?
A study of relative prevalence in comparison
with population controls. Scandinavian
journal of gastroenterology, 42(10),
1214–1220.
-
Pinto-Sanchez, M. I., Seiler, C. L., Santesso,
N., Alaedini, A., Semrad, C., Lee, A.
R., Bercik, P., Lebwohl, B., Leffler, D. A.,
Kelly, C. P., Moayyedi, P., Green, P. H., &
Verdu, E. F. (2020). Association Between
Inflammatory Bowel Diseases and Celiac
Disease: A Systematic Review and Meta-
Analysis. Gastroenterology, 159(3),
884–903.e31.
-
Casella, G., D’Incà, R., Oliva, L., Daperno,
M., Saladino, V., Zoli, G., Annese, V.,
Fries, W., Cortellezzi, C., & Italian Group -
IBD (2010). Prevalence of celiac disease in
inflammatory bowel diseases: An IG-IBD
multicentre study. Digestive and liver disease
: official journal of the Italian Society
of Gastroenterology and the Italian Association
for the Study of the Liver, 42(3),
175–178.
Nadir Bir Birliktelik: Çölyak Hastalığı ve Ülseratif Kolit
Year 2026,
Volume: 9 Issue: 1, 15 - 18, 16.03.2026
Ahmet Uyanıkoğlu
,
Serpil Uyanikoğlu
,
Dursun Çadırcı Barut
Abstract
Çölyak hastalığı (ÇH) daha çok ince barsağı etkilemekle birlikte tüm sistemleri etkileyen kronik otoimmün bir enteropatidir. İnflamatuar barsak hastalığı (İBH) olan ülseratif kolitte (ÜK) ise gastrointestinal sistemin tekrarlayan immun aktivasyonu ve inflamasyonu vardır. Literatüre göre ÇH-ÜK birlikteliğinin sık olmadığı saptanmıştır. Bu makalede ÇH tanısı olan hastada ÜK gelişen genç bir kadın hasta sunulmuştur.
References
-
Catassi, C., Verdu, E. F., Bai, J. C., & Lionetti,
E. (2022). Coeliac disease. Lancet
(London, England), 399(10344), 2413–
2426.
-
Malamut, G., Soderquist, C. R., Bhagat, G.,
& Cerf-Bensussan, N. (2024). Advances in
Nonresponsive and Refractory Celiac Disease.
Gastroenterology, 167(1), 132–147.
-
Rubio-Tapia, A., Hill, I. D., Kelly, C. P.,
Calderwood, A. H., Murray, J. A., & American
College of Gastroenterology (2013).
ACG clinical guidelines: diagnosis and
management of celiac disease. The American
journal of gastroenterology, 108(5),
656–677.
-
Ludvigsson, J. F., Bai, J. C., Biagi, F., Card,
T. R., Ciacci, C., Ciclitira, P. J., Green, P.
H., Hadjivassiliou, M., Holdoway, A., van
Heel, D. A., Kaukinen, K., Leffler, D. A.,
Leonard, J. N., Lundin, K. E., McGough,
N., Davidson, M., Murray, J. A., Swift, G.
L., Walker, M. M., Zingone, F., … British
Society of Gastroenterology (2014).
Diagnosis and management of adult coeliac
disease: guidelines from the British
Society of Gastroenterology. Gut, 63(8),
1210–1228.
-
Kaplan G. G. (2015). The global burden of
IBD: from 2015 to 2025. Nature reviews.
Gastroenterology & hepatology, 12(12),
720–727.
-
Assa, A., Frenkel-Nir, Y., Tzur, D., Katz, L.
H., & Shamir, R. (2017). Large population
study shows that adolescents with celiac
disease have an increased risk of multiple
autoimmune and nonautoimmune comorbidities.
Acta paediatrica (Oslo, Norway :
1992), 106(6), 967–972.
-
Ghersin, I., Khateeb, N., Katz, L. H., Daher,
S., Shamir, R., & Assa, A. (2020).
Comorbidities in adolescents with inflammatory
bowel disease: findings from a population-
based cohort study. Pediatric research,
87(7), 1256–1262.
-
Pinto-Sanchez, M. I., Verdu, E. F., Gordillo,
M. C., Bai, J. C., Birch, S., Moayyedi,
P., & Bercik, P. (2015). Tax-deductible
provisions for gluten-free diet in Canada
compared with systems for gluten-free diet coverage available in various countries.
Canadian journal of gastroenterology
& hepatology, 29(2), 104–110.
-
Oxford, E. C., Nguyen, D. D., Sauk, J.,
Korzenik, J. R., Yajnik, V., Friedman, S.,
& Ananthakrishnan, A. N. (2013). Impact
of coexistent celiac disease on phenotype
and natural history of inflammatory bowel
diseases. The American journal of gastroenterology,
108(7), 1123–1129.
-
Braun, T., Sosnovski, K. E., Amir, A.,
BenShoshan, M., VanDussen, K. L., Karns,
R., Levhar, N., Abbas-Egbariya, H.,
Hadar, R., Efroni, G., Castel, D., Avivi, C.,
Rosen, M. J., Grifiths, A. M., Walters, T.
D., Mack, D. R., Boyle, B. M., Ali, S. A.,
Moore, S. R., Schirmer, M., … Haberman,
Y. (2023). Mucosal transcriptomics highlight
lncRNAs implicated in ulcerative colitis,
Crohn’s disease, and celiac disease. JCI
insight, 8(14), e170181.
-
Shah, A., Walker, M., Burger, D., Martin,
N., von Wulffen, M., Koloski, N., Jones,
M., Talley, N. J., & Holtmann, G. J. (2019).
Link Between Celiac Disease and Inflammatory
Bowel Disease. Journal of clinical
gastroenterology, 53(7), 514–522.
-
Leeds, J. S., Höroldt, B. S., Sidhu, R.,
Hopper, A. D., Robinson, K., Toulson, B.,
Dixon, L., Lobo, A. J., McAlindon, M. E.,
Hurlstone, D. P., & Sanders, D. S. (2007).
Is there an association between coeliac disease
and inflammatory bowel diseases?
A study of relative prevalence in comparison
with population controls. Scandinavian
journal of gastroenterology, 42(10),
1214–1220.
-
Pinto-Sanchez, M. I., Seiler, C. L., Santesso,
N., Alaedini, A., Semrad, C., Lee, A.
R., Bercik, P., Lebwohl, B., Leffler, D. A.,
Kelly, C. P., Moayyedi, P., Green, P. H., &
Verdu, E. F. (2020). Association Between
Inflammatory Bowel Diseases and Celiac
Disease: A Systematic Review and Meta-
Analysis. Gastroenterology, 159(3),
884–903.e31.
-
Casella, G., D’Incà, R., Oliva, L., Daperno,
M., Saladino, V., Zoli, G., Annese, V.,
Fries, W., Cortellezzi, C., & Italian Group -
IBD (2010). Prevalence of celiac disease in
inflammatory bowel diseases: An IG-IBD
multicentre study. Digestive and liver disease
: official journal of the Italian Society
of Gastroenterology and the Italian Association
for the Study of the Liver, 42(3),
175–178.