Comparison of the Effectiveness of Diet on the Systemic Immune-Inflammation Index in the Treatment of Acne Vulgaris With Isotretinoin

Year 2026, Volume: 9 Issue: 1, 1 - 5, 16.03.2026

Hilal Güven , Faik Özdengül , İlkay Özer , Raviye Özen Koca , Z Işık Solak Görmüş

https://izlik.org/JA72DZ33WB

Abstract

Objective: Acne vulgaris is a systemic inflammatory disease. The consumption of milk and dairy products is considered a triggering factor in the etiopathogenesis of the disease. However, there is also evidence that milk and dairy products may reduce systemic inflammation. The systemic inflammatory development of isotretinoin, which is effectively used in the treatment of acne vulgaris, is controversial. The change in inflammation parameters during isotretinoin treatment with the use of milk and dairy products, which are triggers for acne, will facilitate understanding the effect of diet on the treatment of acne vulgaris. Materials and Methods: Sixty patients receiving systemic isotretinoin treatment for acne vulgaris were included in the study, and 30 patients were given a diet low in milk and dairy products in addition to their treatment. Results: When the values of all patients before treatment and at the 3rd month of treatment were examined, a decrease in neutrophil and lymphocyte counts and NLR, and an increase in platelet count and SII were observed, but these changes were not statistically significant. When intergroup changes were examined, no differences were observed in neutrophil, lymphocyte, and platelet counts or in SII and NLR values. Conclusion: A diet low in milk and dairy products has no effect on neutrophil, lymphocyte, and platelet counts or on SII and NLR values during the treatment of acne vulgaris.

Keywords

diet , milk , NLR , SII.

Akne Vulgarisin İzotretinoin ile Tedavisinde Diyetin Sistemik İmmün-İnflamasyon İndeksi Üzerine Etkinliğinin Karşılaştırılması

https://izlik.org/JA72DZ33WB

Abstract

Amaç: Akne vulgaris sistemik inflamatuar bir hastalıktır. Hastalığın etyopatogenezinde süt ve süt ürünlerinin kullanılması tetikleyici bir faktör olarak görülmektedir. Bununla birlikte süt ve sütürünlerinin sistemik inflamasyonu azaltabileceğine dair veriler de bulunmaktadır. Akne vulgarisin tedavinde etkin olarak kullanılan isotretinoinin sistemik inflamatuar gelişimi tartışmalıdır. Akne tetikleyicisi olan süt ve süt ürünlerinin kullanımı ile isotretinoin tedavisi sırasındaki inflamasyon parametrelerinin değişimi diyetin akne vulgaris tedavisi üzerine etkisini anlamayı kolaylaştıracaktır. Gereç ve Yöntem: çalışmaya akne vulgaris nedeni ile sistemik isotretinoin tedavisi alan 60 hasta dahil edilip 30 hastaya tedavilerine ek olarak süt ve süt ürünlerinden fakir diyet verilmiştir. Bulgular: Tüm hastaların tedavi öncesinde ve tedavinin 3. aydındaki değerleri incelendiğinde neutrofil ve lenfosit sayısının, NLR’nın azaldığı, trombosit sayısının ve Sİİ’nin arttığı izlendi ancak bu değişiklikler istatistiksel olarak anlamlı değildi. gruplar arası değişiklikler incelendiğinde neutrofil, lenfosit, trombosit sayılarında ve SII, NLR değerlerinde farklılık izlenmedi. Sonuç: süt ve süt ürünlerinden fakir beslenmenin akne vulgaris tedavisi sırasında neutrofil, lenfosit, trombosit sayılarında ve SII, NLR değerlerine etkisi bulunamamaktadır.

Keywords

diyet , NLR , SII , süt

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