COVİD-19 PANDEMİSİ VE KOKU BOZUKLUĞU PATOGENESİ; GÜNCEL BİR DERLEME

Abstract

Bir solunum yolu enfeksiyon ajanı olarak bilinen korona virüs kaynaklı covid 19 pandemisi, daha önceki salgınlarından farklı olarak koku kaybı ile ön plana çıkmıştır. Koku kaybının izole, ani başlangıçlı ve genellikle total kayıp şeklinde klinik seyre sahip olduğu, hastaların önemli kısmında nasal obstrüksiyon veya rinore olmadan görüldüğü ve olfaktor disfonksiyonun genel semptomlardan önce, bu semptomlarla birlikte veya sonradan ortaya çıkabildiği görülmiştür. Koku kaybı gelişimi ile ilgili hipotezler arasında olfaktor sensoryal nöronların kaybı, olfaktor epiteldeki destek hücrelerinin hasar görmesi, koronavirüslerin nörotropik potansiyeli ile olfaktor bulbus ve veya kokuyla ilişkili beyin alanlarını etkilemesi yer almaktadır. Patofizyolojiyi ortaya koyan bu çalışmalar postviral koku kaybına ışık tutacağı gibi yeni tedavi modaliteleri geliştirmek açısından da önem arz etmektedir.

Keywords

• Covid-19 pandemisi
• koku kaybı
• patogenez

PATHOGENESIS OF OLFACTORY DYSFUNCTIONS IN THE COVID-19 PANDEMIC; UP TO DATE REVİEW

Abstract

Covid 19 pandemic caused by corona virüs come along with olfactory loss, unlike its previous outbreaks. It has been observed that the olfactory loss has an isolated, sudden onset type and usually clinical course was a total loss. It was seen in most of the patients without nasal obstruction or rhinorrhea, and olfactory dysfunction may occur before, with or after the general symptoms. Hypotheses for the development of olfactory loss include the loss of olfactory sensorial neurons, damage to the supporting cells in the olfactory epithelium, the neurotropic potential of coronaviruses, and their affecting the olfactory bulbus and or olfactory-related brain areas. Studies revealing the pathophysiology are important for understanding the postviral olfactory loss as well as developing new treatment modalities

Keywords

• Covid-19 pandemic
• olfactory loss
• pathogenesis

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