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Membran Fosfolipidlerinden Sfingozin-1-Fosfat ve Reseptörlerinin Erektil Disfonksiyondaki Rolü

Year 2018, Volume: 1 Issue: 3, 17 - 21, 30.11.2018

Abstract

Erektil disfonksiyon (ED), erektil dokuya kan akışındaki değişimin en sık neden olduğu bir
dizi dinamik olayın sonucu olarak oluşur. ED’ye sebep olan Kavernozal fibrozis, diyabet,
hipertansiyon, radikal prostatektomi, Peyronie hastalığı, kastrasyon ve kavernozal sinir hasarı
gibi durumlarda ortaya çıkan önemli bir patolojik durumdur. Birçok faktörün yanında, bu
hastaların plazmasında sfingozin-1-fosfat (S1P)’ın yüksek seviyede bulunması, bu mekanizma
üzerinde potansiyel bir belirleyici olabileceği görüşünün ortaya çıkmasına neden olmuştur.
Sfingolipitler olarak adlandırılan büyük lipit metabolitleri ailesinin bir üyesi olan sfingozin-
1-fosfat (S1P), vasküler tonusu düzenleyen maddelerin en son belirlenenlerindendir. İnsan
korpus kavernozumda S1P’nin reseptörlerinden S1P1, S1P2 ve S1P3’ün varlığı bildirilmiştir.
Reseptörleri aracılığıyla, S1P’nin düz kaslar üzerindeki etkisi vasküler yanıtın oluşmasını
sağlar. Erektil disfonksiyonda S1P ve ona bağlı çeşitli sinyal yolakları terapötik hedeflerin
oluşturulması bakımından önemlidir. Bu konu hakkında mevcut bilginin kısıtlı olması nedeniyle,
hem mekanizmaların ortaya konması hem de özel tedavilere odaklanılması açısından daha ileri
araştırmalara ihtiyaç olduğu görülmektedir.
  

References

  • 1. di Villa Bianca Rd, Sorrentino R, Sorrentino R, et al. Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. J Pharmacol Exp Ther 2006; 316(2): 703-708. 2. Nazlıkul H. Erektil Disfonksiyon. Bilimsel Tamamlayıcı Tıp, Regülasyon ve Nöralterapi Dergisi 2016; 10(2): 7. 3. Yin J, Guo YM, Chen P, et al. Testosterone regulates the expression and functional activity of sphingosine‐1‐phosphate receptors in the rat corpus cavernosum. J Cell Mol Med 2018; 22(3): 1507- 1516. 4. Kim RH, Takabe K, Milstien S, et al. Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta 2009; 1791: 692–696. 5. Sarkar S, Maceyka M, Hait NC, et al. Sphingosinekinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Letters 2005; 579: 5313-5317. 6. Geho DH, Bandle RW, Clair T, et al. Physiological Mechanisms of Tumor-Cell Invasion and Migration. Physiology 2005; 20: 194-200. 7. Taha TA, Argraves KM and Obeid LM. Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta 2004; 1682(1): 48-55. 8. Hla T. Sphingosine 1-phosphate receptors. Prostaglandins Other Lipid Mediat 2001; 64(1): 135-142. 9. Watson C, Long JS, Orange C, et al. High expression of sphingosine 1-phosphate receptors, S1P 1 and S1P 3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. Am J Pathol. 2010; 177(5): 2205-2215. 10. Hisano Y, Nishi T and Kawahara A. The functional roles of S1P in immunity. J Biochem. 2012; 152(4): 305-311. 11. Michel MC, Mulders AC, Jongsma M, et al. Vascular effects of sphingolipids. Acta Paediatr. 2007; 96: 44-48. 12. Igarashi J. and Michel T. Sphingosine-1- phosphate and modulation of vascular tone. Cardiovasc Res. 2009; 82(2): 212-220. 13. Schuchardt M, Tölle M, Prüfer J, et al. Pharmacological relevance and potential of sphingosine 1‐phosphate in the vascular system. Br J Pharmacol. 2011; 163(6): 1140-1162. 14. Zhang Xh, Melman A, and DiSanto ME. Update on corpus cavernosum smooth muscle contractile pathways in erectile function: a role for testosterone? J Sex Med. 2011; 8(7): 1865-1879. 15. Cho MC, Song WH and Paick JS. Suppression of Cavernosal Fibrosis in a Rat Model. Sex Med Rev. 2018; 6(4): 572-582. 16. Cho MC, Park K and Chai JS. Involvement of sphingosine‐1‐phosphate/RhoA/Rho‐kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats. J Sex Med. 2011; 8(3): 712-721.
Year 2018, Volume: 1 Issue: 3, 17 - 21, 30.11.2018

Abstract

References

  • 1. di Villa Bianca Rd, Sorrentino R, Sorrentino R, et al. Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. J Pharmacol Exp Ther 2006; 316(2): 703-708. 2. Nazlıkul H. Erektil Disfonksiyon. Bilimsel Tamamlayıcı Tıp, Regülasyon ve Nöralterapi Dergisi 2016; 10(2): 7. 3. Yin J, Guo YM, Chen P, et al. Testosterone regulates the expression and functional activity of sphingosine‐1‐phosphate receptors in the rat corpus cavernosum. J Cell Mol Med 2018; 22(3): 1507- 1516. 4. Kim RH, Takabe K, Milstien S, et al. Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta 2009; 1791: 692–696. 5. Sarkar S, Maceyka M, Hait NC, et al. Sphingosinekinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Letters 2005; 579: 5313-5317. 6. Geho DH, Bandle RW, Clair T, et al. Physiological Mechanisms of Tumor-Cell Invasion and Migration. Physiology 2005; 20: 194-200. 7. Taha TA, Argraves KM and Obeid LM. Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta 2004; 1682(1): 48-55. 8. Hla T. Sphingosine 1-phosphate receptors. Prostaglandins Other Lipid Mediat 2001; 64(1): 135-142. 9. Watson C, Long JS, Orange C, et al. High expression of sphingosine 1-phosphate receptors, S1P 1 and S1P 3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. Am J Pathol. 2010; 177(5): 2205-2215. 10. Hisano Y, Nishi T and Kawahara A. The functional roles of S1P in immunity. J Biochem. 2012; 152(4): 305-311. 11. Michel MC, Mulders AC, Jongsma M, et al. Vascular effects of sphingolipids. Acta Paediatr. 2007; 96: 44-48. 12. Igarashi J. and Michel T. Sphingosine-1- phosphate and modulation of vascular tone. Cardiovasc Res. 2009; 82(2): 212-220. 13. Schuchardt M, Tölle M, Prüfer J, et al. Pharmacological relevance and potential of sphingosine 1‐phosphate in the vascular system. Br J Pharmacol. 2011; 163(6): 1140-1162. 14. Zhang Xh, Melman A, and DiSanto ME. Update on corpus cavernosum smooth muscle contractile pathways in erectile function: a role for testosterone? J Sex Med. 2011; 8(7): 1865-1879. 15. Cho MC, Song WH and Paick JS. Suppression of Cavernosal Fibrosis in a Rat Model. Sex Med Rev. 2018; 6(4): 572-582. 16. Cho MC, Park K and Chai JS. Involvement of sphingosine‐1‐phosphate/RhoA/Rho‐kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats. J Sex Med. 2011; 8(3): 712-721.
There are 1 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research article
Authors

Didem Turgut Coşan This is me

İbrahim Uğur Çalış This is me

Gülcan Kalender Güleç This is me

Publication Date November 30, 2018
Acceptance Date September 21, 2018
Published in Issue Year 2018 Volume: 1 Issue: 3

Cite

APA Turgut Coşan, D., Çalış, İ. U., & Kalender Güleç, G. (2018). Membran Fosfolipidlerinden Sfingozin-1-Fosfat ve Reseptörlerinin Erektil Disfonksiyondaki Rolü. Tıp Fakültesi Klinikleri Dergisi, 1(3), 17-21.


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