Covid-19 and Cancer

Year 2021, Volume: 4 Issue: 1, 1 - 14, 01.03.2021

Matem Tunçdemir , Metehan Karataş

Abstract

SARS-CoV-2, the new member of the coronavirus family, is a virus that emerged in Wuhan, China in December 2019 and caused a pandemic all over the world. This disease, called Covid-19, increases the risk of death in individuals over 65 years of age and with chronic diseases. Cytokine Storm is one of the most serious mechanisms that trigger death in the pathogenesis of Covid-19. Although studies are ongoing for a vaccine against this disease or a drug that will affect its pathogenesis, an effective treatment method has not been found. The rapid spread of the virus and the increase in the number of cases have caused a problems in the health sector, and guidelines have been published to reduce the risk of infection of individuals who have not been diagnosed with Covid-19 but have serious illnesses such as cancer. In this review, we will discuss the origin and pathology of Covid-19, why its mortality is higher in certain situations, as well as the effect of this disease on the life of cancer patients, complications in cancer patients diagnosed with Covid-19, the effect of inhibitors used in cancer treatment on Covid-19 and lastly guidelines and studies will be discussed for cancer patients in global pandemic.

Keywords

SARS-CoV-2, Covid-19, Cancer, Cytokine, ACE2

Covid-19 ve Kanser

Abstract

2019 Aralık Ayında Çin’in Wuhan şehrinde ortaya çıkan ve koronavirüs ailesinin yeni üyesi olan SARS-CoV-2 kısa sürede tüm Dünya’ya yayılmış ve pandemi ilan edilmesine neden olmuş bir virüstür. Covid-19 olarak adlandırılan bu hastalık kronik rahatsızlığı bulunan ve yaşı 65 üzeri olan bireylerde ölüm riskini arttırmaktadır. Covid-19’un patogenezinde ölümü tetikleyen en ciddi mekanizmaların başında oluşturduğu Sitokin Fırtınası gelmektedir. Günümüzde hastalığa karşı aşı veya bu mekanizmaları düzenleyecek bir ilaç araştırmaları devam etse de ne yazık ki henüz net bir tedavi yöntemi bulunmamaktadır. Hızlı yayılması ve vaka sayılarındaki artış sağlık sektöründe büyük bir yoğunluğa neden olduğu için Covid-19 tanısı konmayan fakat kanser gibi ciddi rahatsızlıkları olan bireylerin enfekte olma riskini azaltmaya yönelik kılavuzlar yayınlanmıştır. Bu derlemede Covid-19'un kökenini, patolojisini, neden mortalitesinin belirli durumlarda yüksek olduğunun yanı sıra bu hastalığın kanserli hastaların hayatına olan etkisi, Covid-19 tanısı konulan kanser hastalarının tedavisindeki komplikasyonlar ve kanser tedavisinde kullanılan inhibitörlerin Covid-19 üzerine etkisini kapsayan tedavi biçimlerini içeren kılavuz ve çalışmalar tartışılacaktır.

Keywords

SARS-CoV-2, Covid-19, Kanser, Sitokin, ACE2

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