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Effect of synthesis parameters on isoniazid (INH) release from silica nanospheres

Year 2016, Volume: 17 Issue: 5, 905 - 914, 20.12.2016
https://doi.org/10.18038/aubtda.279858

Abstract

Silica nanospheres containing isoniazid (INH) was synthesized based on a modified Stober process. Synthesis parameters such as type of alcohol used as oil phase, tetra ethyl ortho silicate (TEOS) and ammonia (NH3) amounts, surfactant use and mixing time were altered and their effect on the release of INH was investigated. Results indicated lower amount of INH release when higher amount of TEOS was utilized in synthesis. Time of highest INH release was higher in the case of higher TEOS amount. NH3 had also a decreasing effect on INH release which had been due to the changes in pore structure. Scanning electron microscope (SEM) results clearly showed the necessity of surfactant use with smooth surfaces obtained with the samples where surfactant was utilized. Finally, mixing time was found to have a decreasing effect on the time of highest INH release and the amount of INH released from the spheres was also higher in the case of higher mixing time.

Year 2016, Volume: 17 Issue: 5, 905 - 914, 20.12.2016
https://doi.org/10.18038/aubtda.279858

Abstract

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Details

Subjects Engineering
Journal Section Articles
Authors

Nagihan Karakaya This is me

Levent Değirmenci

Publication Date December 20, 2016
Published in Issue Year 2016 Volume: 17 Issue: 5

Cite

APA Karakaya, N., & Değirmenci, L. (2016). Effect of synthesis parameters on isoniazid (INH) release from silica nanospheres. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, 17(5), 905-914. https://doi.org/10.18038/aubtda.279858
AMA Karakaya N, Değirmenci L. Effect of synthesis parameters on isoniazid (INH) release from silica nanospheres. AUJST-A. December 2016;17(5):905-914. doi:10.18038/aubtda.279858
Chicago Karakaya, Nagihan, and Levent Değirmenci. “Effect of Synthesis Parameters on Isoniazid (INH) Release from Silica Nanospheres”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17, no. 5 (December 2016): 905-14. https://doi.org/10.18038/aubtda.279858.
EndNote Karakaya N, Değirmenci L (December 1, 2016) Effect of synthesis parameters on isoniazid (INH) release from silica nanospheres. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17 5 905–914.
IEEE N. Karakaya and L. Değirmenci, “Effect of synthesis parameters on isoniazid (INH) release from silica nanospheres”, AUJST-A, vol. 17, no. 5, pp. 905–914, 2016, doi: 10.18038/aubtda.279858.
ISNAD Karakaya, Nagihan - Değirmenci, Levent. “Effect of Synthesis Parameters on Isoniazid (INH) Release from Silica Nanospheres”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17/5 (December 2016), 905-914. https://doi.org/10.18038/aubtda.279858.
JAMA Karakaya N, Değirmenci L. Effect of synthesis parameters on isoniazid (INH) release from silica nanospheres. AUJST-A. 2016;17:905–914.
MLA Karakaya, Nagihan and Levent Değirmenci. “Effect of Synthesis Parameters on Isoniazid (INH) Release from Silica Nanospheres”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, vol. 17, no. 5, 2016, pp. 905-14, doi:10.18038/aubtda.279858.
Vancouver Karakaya N, Değirmenci L. Effect of synthesis parameters on isoniazid (INH) release from silica nanospheres. AUJST-A. 2016;17(5):905-14.