IN VITRO BIOLOGICAL ACTIVITY STUDIES ON TANACETUM ABROTANIFOLIUM (L.) DRUCE (ASTERACEAE)

Year 2017, Volume: 18 Issue: 2, 439 - 455, 30.06.2017

İbrahim Geçibesler

https://doi.org/10.18038/aubtda.284496

Cited By: 2

Abstract

Tanacetum
L. (Asteraceae) species have been used by local
people in folk medicine for centuries in Turkey to treat antipyretic, headache,
tinnitus, dizziness and against difficulties in childbirth. We performed
detailed biological activity screening tests of Tanacetum abrotanifolium, collected from its natural habitats in
the eastern region of Turkey, for the first time. To obtain active compound
from aerial parts of T. abrotanifolium
by using chromatographic techniques, anticancer, antimicrobial and antioxidant
assays were applied. Total phenol, flavonoid, β-carotene and lycopene contents were determined quantitatively.
The isolation procedure was carried out successfully through thin layer and
column chromatographies. Bioactivity-guided fractionation led to the isolation
of luteolin-7-O-glucoside, an agent
of anticancer, antimicrobial and antioxidant. This active compound was isolated
from aerial parts of T. abrotanifolium
for the first time.

Keywords

Tanacetum abrotanifolium, luteolin-7-O-glucoside, anticancer activity, antimicrobial potency

References

• [1] Rates SMK. Plants as source of drugs. Toxicon 2001 39: 603-613.
• [2] Jassim SAA & Naji MA Novel antiviral agents: a medicinal plant perspective. J Applied Microbiol 2003; 95: 412-427.
• [3] Cos P, Vlietinck AJ, Vanden Berghe D, Maes L. Anti-infective potential of natural products: how to develop a stronger in vitro ‘proof-of concept’. J Ethnopharmacol 2006; 106: 290–302.
• [4] OBryan CA, Crandall PG, Ricke SC. Organic poultry pathogen control from farm to fork. Foodborne Pathog Dis 2008; 5: 709–720.
• [5] Janovska D, Kubikova K, & Kokoska L. Screening for antimicrobial activity of some medicinal plant species of traditional Chinese medicine. Czech J Food Sci 2003; 21: 107-111.
• [6] Brown AM, Edwards CM, Davey MR, Power JB, and Lowe KC. Effects of extracts of Tanacetum species on human polymorphonuclear leucocyte activity in vitro. Phytother Res 1997; 11: 479–484.
• [7] Jain NK, and Kulkarni SK. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. J Ethnopharmacol 1999; 68: 251– 259.
• [8] Williams C, Harborne JB, Geiger HJ, Robin and Hoult S. The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties. Phytochemistry 1999; 51: 417–423.
• [9] Hwang DR, Wu YS, Chang CW, Lien TW, Chen WC, Tan UK, John TA, Hsua JTA, and Hsieh HP. Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system. Bioorg Med Chem 2006; 14: 83–91.
• [10] Jordan CT, The leukemic stem cell. Best Practice Res Clin Haematol 2007; 20: 13–18.
• [11] Gecibesler IH, Demirtas I, & Koçak A. Based on the quantity, temperature and time, the examination of variability in odorous components of Tanacetum abrotanifolium from Turkey: An exclusive gradient work. J Essent Oil Bear Pl 2015; 18: 840-843.
• [12] Polatoğlu K, Karakoç ÖC, Yücel YY, Demirci B, Gören, N, & Başer KHC. Composition, insecticidal activity and other biological activities of Tanacetum abrotanifolium Druce. essential oil. Ind Crop Prod 2015; 71: 7-14.
• [13] Gecibesler IH, Kocak A, & Demirtas I. Biological activities, phenolic profiles and essential oil components of Tanacetum cilicicum (Boiss.) Grierson. Nat Prod Res 2016; 30: 2850-2855.
• [14] Dewanto V, Wu X, Adom KK, and Liu RH. Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J Agr Food Chem 2002; 50: 3010-3014.
• [15] Nagata M, and Yamashita I. Simple method for simultaneous determination of chlorophyll and carotenoids in tomato fruit. Nippon Shokuhin Kogyo Gakk 1992; 39:925–928.
• [16] Eloff JN. Which extractant should be used for the screening and isolation of antimicrobial component from plants? J Ethnopharmacol 1998; 60: 1-8.
• [17] Vlietinck AJ, Vanden Berghe DA. Can ethnopharmacology contribute to the development of antiviral drugs? J Ethnopharmacol 1991; 32: 141-153.
• [18] Zovko Koncic D, Kremer K, Karlovic K, and Kosalec I. Evaluation of antioxidant activities and phenolic content of Berberis vulgaris and Berberis croatica. Food Chem Toxicol 2010; 48: 2176-2180.
• [19] Decker EA, and Welch B. Role of ferritin as lipid oxidation catalyst in muscle food. J Agr Food Chem 1990; 38: 674-677.
• [20] Oyaizu M. Studies on products of the browning reaction. Antioxidative activities of browning reaction products prepared from glucosamine. Jpn J Nutr 1986; 44: 307-315.
• [21] Prieto P, Pineda M, & Aguilar M Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of vitamin E. Anal Biochem 1999; 269: 337−341.
• [22] Re R, Pellegrini N, Proteggente A, Pannala, A, Yang M, & Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolourization assay. Free Radical Bio Med 1999; 26: 1231–1237.
• [23] Belboukhari N. & Cheriti A. Phytochemical investigation of the bioactive extract from Launaeae arborescens. Pak J Biosci Sci 2006; 9:2930–2932.
• [24] Conforti F, Marrelli M, Carmela C, Menichini F, Valentina P, Uzunovc D, Statti G,A, Duez P, Menichini F. Bioactive phytonutrients (omega fatty acids, tocopherols, polyphenols), in vitro inhibition of nitric oxide production and free radical scavenging activity of non-cultivated Mediterranean vegetables. Food Chem 2011; 125: 660–664.
• [25] Duarte-Almeida JM, Salatino A, Genovese MI, Lajolo FM. Phenolic composition and antioxidant activity of culms and sugarcane (Saccharum officinarum L.) products. Food Chem 2011; 125: 660–664.
• [26] Lin YP, Chen TY, Tseng HW, Lee M,H, Chen ST. Neural cell protective compounds isolated from Phoenix hanceana var. formosana. Phytochemistry 2009; 70: 1173–1181.
• [27] Brand Williams W, Cuvelier MC, & Berset C. Use of a free-radical method to evaluate antioxidant activity. Lebensm Wiss Technol 1995; 28: 25–30.
• [28] Chen Y, Wang M, Rosen RT, & Ho CT. DPPH scavenging active components from Polygonum multiflorum Thunb. J Agr Food Chem 1999; 47: 2226–2228.
• [29] Sanchez-Moreno C, Larrauri JA, & Saura-Calixto F. Free radical scavenging capacity of selected red rose and white wines. J Sci Food Agr 1999; 79: 1301–1304.
• [30] Atienza JM, Zhu J, Wang X, Xu X, Abassi Y. Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays. J Biomol Screen 2005; 10: 795–805.