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CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS

Year 2017, Volume: 18 Issue: 3, 543 - 553, 30.06.2017
https://doi.org/10.18038/aubtda.322138

Abstract

Controlled drug release systems present a significant alternative to the conventional drug dosages providing drug release for prolonged time periods. Nanocomposite hydrogels offer an important potential for drug release with enhanced physicochemical properties. In this study, the preparation of carbon nanotube (CNT)-based Polyvinylalcohol-Polyvinylpyrolidone (PVA/PVP) nanocomposite hydrogels namely, CNT-25, CNT-50 and CNT-100 were succedded via the freeze/thawing method with the addition of different amounts of CNT. The nanocomposite hydrogels were characterized by swelling tests, FT-IR, DSC, SEM and BET measurements. It was determined that CNT-50 was the most suitable hydrogel for drug release studies having better morhological properties with homogenous distribution of CNT throughout the polymeric nanocomposite matrix. The release of 5-fluororacil (5-FU) as a model drug was investigated in-vitro. The release of 5-FU from CNT-based PVA/PVP nanocomposite hydrogels was exhibited controlled release for one week at pH 7.4. The amount of released of 5-FU was effectively increased with the addition of CNT into the hydrogel matrix.  Korsmeyer-Peppas model was well fitted for determining the release mechanism of 5-FU from CNT-based PVA/PVP nanocomposite hydrogels corresponding the combination of diffusion of the drug and the dissolution of polymer chains.  

Year 2017, Volume: 18 Issue: 3, 543 - 553, 30.06.2017
https://doi.org/10.18038/aubtda.322138

Abstract

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Details

Subjects Engineering
Journal Section Articles
Authors

Emel Tamahkar Irmak

Publication Date June 30, 2017
Published in Issue Year 2017 Volume: 18 Issue: 3

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APA Tamahkar Irmak, E. (2017). CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, 18(3), 543-553. https://doi.org/10.18038/aubtda.322138
AMA Tamahkar Irmak E. CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS. AUJST-A. September 2017;18(3):543-553. doi:10.18038/aubtda.322138
Chicago Tamahkar Irmak, Emel. “CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 18, no. 3 (September 2017): 543-53. https://doi.org/10.18038/aubtda.322138.
EndNote Tamahkar Irmak E (September 1, 2017) CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 18 3 543–553.
IEEE E. Tamahkar Irmak, “CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS”, AUJST-A, vol. 18, no. 3, pp. 543–553, 2017, doi: 10.18038/aubtda.322138.
ISNAD Tamahkar Irmak, Emel. “CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 18/3 (September 2017), 543-553. https://doi.org/10.18038/aubtda.322138.
JAMA Tamahkar Irmak E. CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS. AUJST-A. 2017;18:543–553.
MLA Tamahkar Irmak, Emel. “CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, vol. 18, no. 3, 2017, pp. 543-5, doi:10.18038/aubtda.322138.
Vancouver Tamahkar Irmak E. CARBON NANOTUBE BASED POLYVINYLALCOHOL-POLYVINYLPYROLIDONE NANOCOMPOSITE HYDROGELS FOR CONTROLLED DRUG DELIVERY APPLICATIONS. AUJST-A. 2017;18(3):543-5.