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PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN

Year 2017, Volume: 18 Issue: 5, 962 - 972, 31.12.2017
https://doi.org/10.18038/aubtda.319445

Abstract

In
this study, modification of glassy carbon electrode with electrochemically
reduced graphene oxide (ERGO) and acid treated multi-walled carbon nanotubes
(A-MWCNT) was investigated for the voltammetric determination of LEV in body
fluids and pharmaceutical products. Different combinations of GO, ERGO, MWCNT
and A-MWCNT were searched and the best results obtained with GC/ERGO/A-MWCNT
electrode. The prepared modified electrode showed electrocatalytic acitivity
towards LEV oxidation by increasing oxidation peak currents 293 times.
Characterizations of the modified electrode was performed with cyclic
voltammetry, electrochemical impedance spectroscopy and raman measurements. The
highest oxidation peak current was observed at pH value of 2.0. The oxidation
peak currents of LEV increased linearly with the concentration of LEV in the
range of 0.01
mM and 10 mM. The
detection limit of the prepared sensor was determined as 0.0063
mM. After three weeks’ storage, the prepared electrode
showed high stability by preserving 93% of its original activity towards 1.0
mM LEV. The prepared electrode successfully
discriminates the voltammetric response of LEV from that of other
fluoroquinolone antibiotics (enoxacin, norfloxacin, ciprofloxacin). Finally,
the performance of the prepared electrode was tested in the determination of
LEV in human blood serum, urine and pharmaceutical samples.

References

  • Basu P.P., Rayapudi K., Pacana T., Shah N.J., Krishnaswamy N., Flynn M. A Randomized Study Comparing Levofloxacin, Omeprazole, Nitazoxanide, and Doxycycline versus Triple Therapy for the Eradication of Helicobacter pylori. Am J Gastroenterol 2011; 106; 1970–1975.
  • Aguilar‐Carrasco J.C., Hernández‐Pineda J., Jiménez‐Andrade J.M., Flores‐Murrieta F.J., Carrasco‐Portugal M.C., López‐Canales J.S. Rapid and sensitive determination of levofloxacin in microsamples of human plasma by high‐performance liquid chromatography and its application in a pharmacokinetic study. Biomed Chromatogr 2015; 29; 341–345.
  • Wang F., Zhu L., Zhang J. Electrochemical sensor for levofloxacin based on molecularly imprinted polypyrrole-graphene-gold nanoparticles modified electrode. Sens Actuat B Chem 2014; 192; 642–647.
  • Locatelli M., Ciavarella M.T., Paolino D., Celia C., Fiscarelli E., Ricciotti G., Pompilio A., Bonaventura G.D., Grande R., Zengin G., Marzio L.D. Determination of ciprofloxacin and levofloxacin in human sputum collected from cystic fibrosis patients using microextraction by packed sorbent-high performance liquid chromatography photodiode array detector, J. Chromatogr. A. 2015; 1419; 58–66.
  • Lee S.J., Desta K.T., Eum S.Y., Dartois V., Cho S.N., Bae D.W., Shin S.C. Development and validation of LC-ESI-MS/MS method for analysis of moxifloxacin and levofloxacin in serum of multidrug-resistant tuberculosis patients: Potential application as therapeutic drug monitoring tool in medical diagnosis. J. Chromatogr B Anal Technol Biomed Life Sci 2016; 1009–1010; 138–143.
  • Herrera-Herrera A.V., Ravelo-Pérez L.M., Hernández-Borges J., Afonso M.M., Palenzuela J.A., Rodríguez-Delgado M.Á. Oxidized multi-walled carbon nanotubes for the dispersive solid-phase extraction of quinolone antibiotics from water samples using capillary electrophoresis and large volume sample stacking with polarity switching. J Chromatogr A 2011; 1218;5352–5361.
  • Shao X., Li Y., Liu Y., Song Z. Flow injection chemiluminescence determination of levofloxacin in medicine and biological fluids based on its enhancing effect on luminol-H2O2 reaction. Spectroscopy 2009; 23; 209–216.
  • Mazzotta E., Malitesta C., Díaz-Álvarez M., Martin-Esteban A. Electrosynthesis of molecularly imprinted polypyrrole for the antibiotic levofloxacin. Thin Solid Films 2012; 520; 1938–1943.
  • Tang L., Tong Y., Zheng R., Liu W., Gu Y., Li C., Chen R., Zhang Z. Ag nanoparticles and electrospun CeO2-Au composite nanofibers modified glassy carbon electrode for determination of levofloxacin. Sens Actuat B Chem 2014; 203; 95–101.
  • Wen W., Zhao D.M., Zhang X.H., Xiong H.Y., Wang S.F., Chen W., Zhao Y.D. One-step fabrication of poly(o-aminophenol)/multi-walled carbon nanotubes composite film modified electrode and its application for levofloxacin determination in pharmaceuticals. Sens Actuat B Chem 2012; 174; 202–209.
  • Tajabadi M.T., Sookhakian M., Zalnezhad E., Yoon G.H., Hamouda A.M.S., Azarang M., Basirun W.J., Alias Y. Electrodeposition of flower-like platinum on electrophoretically grown nitrogen-doped graphene as a highly sensitive electrochemical non-enzymatic biosensor for hydrogen peroxide detection. Appl Surf Sci 2016; 386; 418–426.
  • Ban F.Y., Jayabal S., Lim H.N., Lee H.W., Huang N.M. Synthesis of nitrogen-doped reduced graphene oxide-multiwalled carbon nanotube composite on nickel foam as electrode for high-performance supercapacitor. Ceram Int 2017; 43; 20–27.
  • Guo C.X., Li C.M. A self-assembled hierarchical nanostructure comprising carbon spheres and graphene nanosheets for enhanced supercapacitor performance. Energy Environ Sci 2011; 4; 4504-4507.
  • Yoo E.J., Kim J., Hosono E., Zhou H.S., Kudo T., Honma I. Large reversible Li storage of graphene nanosheet families for use in rechargeable lithium ion batteries. Nano Lett 2008; 8; 2277-2282.
  • Giannouri M., Bidikoudi M., Pastrana-Martínez L.M., Silva A.M.T., Falaras P. Reduced graphene oxide catalysts for efficient regeneration of cobalt-based redox electrolytes in dye-sensitized solar cells. Electrochim Acta 2016; 219; 258–266.
  • Mukdasai S., Langsi V., Pravda M., Srijaranai S., Glennon J.D. A highly sensitive electrochemical determination of norepinephrine using l-cysteine self-assembled monolayers over gold nanoparticles/multi-walled carbon nanotubes electrode in the presence of sodium dodecyl sulfate. Sens Actuat B Chem 2016; 236; 126–135.
  • Taei M., Salavati H., Hasanpour F., Habibollahi S., Baghlani H. Simultaneous determination of ascorbic acid, acetaminophen and codeine based on multi-walled carbon nanotubes modified with magnetic nanoparticles paste electrode. Mater Sci Eng C 2016; 69; 1–11.
  • Silva T.A., Zanin H., Vicentini F.C., Corat E.J., Fatibello-Filho O. Electrochemical determination of rosuvastatin calcium in pharmaceutical and human body fluid samples using a composite of vertically aligned carbon nanotubes and graphene oxide as the electrode material. Sens Actuat B Chem 2015; 218; 51-59.
  • Raj M.A., John S.A. Fabrication of Electrochemically Reduced Graphene Oxide Films on Glassy Carbon Electrode by Self-Assembly Method and Their Electrocatalytic Application. J Phys Chem C 2013; 117; 4326–4335.
  • Moraes F.C., Silva T.A., Cesarino I., Lanza M.R.V., Machado S.A.S. Antibiotic Detection in Urine Using Electrochemical Sensors Based on Vertically Aligned Carbon Nanotubes, Electroanalysis 2013; 25; 2092–2099.
  • Chi Y., Li J. Determination of levofloxacin hydrochloride with multiwalled carbon nanotubes-polymeric alizarin film modified electrode. Russ J Electrochem 2010; 46; 155–160.
  • Radi A., El Ries M.A., Kandil S. Electrochemical study of the interaction of levofloxacin with DNA. Anal Chim Acta 2003; 495; 61–67.
  • Borowiec J., Yan K., Tin C.C., Zhang J. Synthesis of PDDA Functionalized Reduced Graphene Oxide Decorated with Gold Nanoparticles and Its Electrochemical Response toward Levofloxacin J Electrochem Soc 2015; 162; H164–H169.
Year 2017, Volume: 18 Issue: 5, 962 - 972, 31.12.2017
https://doi.org/10.18038/aubtda.319445

Abstract

References

  • Basu P.P., Rayapudi K., Pacana T., Shah N.J., Krishnaswamy N., Flynn M. A Randomized Study Comparing Levofloxacin, Omeprazole, Nitazoxanide, and Doxycycline versus Triple Therapy for the Eradication of Helicobacter pylori. Am J Gastroenterol 2011; 106; 1970–1975.
  • Aguilar‐Carrasco J.C., Hernández‐Pineda J., Jiménez‐Andrade J.M., Flores‐Murrieta F.J., Carrasco‐Portugal M.C., López‐Canales J.S. Rapid and sensitive determination of levofloxacin in microsamples of human plasma by high‐performance liquid chromatography and its application in a pharmacokinetic study. Biomed Chromatogr 2015; 29; 341–345.
  • Wang F., Zhu L., Zhang J. Electrochemical sensor for levofloxacin based on molecularly imprinted polypyrrole-graphene-gold nanoparticles modified electrode. Sens Actuat B Chem 2014; 192; 642–647.
  • Locatelli M., Ciavarella M.T., Paolino D., Celia C., Fiscarelli E., Ricciotti G., Pompilio A., Bonaventura G.D., Grande R., Zengin G., Marzio L.D. Determination of ciprofloxacin and levofloxacin in human sputum collected from cystic fibrosis patients using microextraction by packed sorbent-high performance liquid chromatography photodiode array detector, J. Chromatogr. A. 2015; 1419; 58–66.
  • Lee S.J., Desta K.T., Eum S.Y., Dartois V., Cho S.N., Bae D.W., Shin S.C. Development and validation of LC-ESI-MS/MS method for analysis of moxifloxacin and levofloxacin in serum of multidrug-resistant tuberculosis patients: Potential application as therapeutic drug monitoring tool in medical diagnosis. J. Chromatogr B Anal Technol Biomed Life Sci 2016; 1009–1010; 138–143.
  • Herrera-Herrera A.V., Ravelo-Pérez L.M., Hernández-Borges J., Afonso M.M., Palenzuela J.A., Rodríguez-Delgado M.Á. Oxidized multi-walled carbon nanotubes for the dispersive solid-phase extraction of quinolone antibiotics from water samples using capillary electrophoresis and large volume sample stacking with polarity switching. J Chromatogr A 2011; 1218;5352–5361.
  • Shao X., Li Y., Liu Y., Song Z. Flow injection chemiluminescence determination of levofloxacin in medicine and biological fluids based on its enhancing effect on luminol-H2O2 reaction. Spectroscopy 2009; 23; 209–216.
  • Mazzotta E., Malitesta C., Díaz-Álvarez M., Martin-Esteban A. Electrosynthesis of molecularly imprinted polypyrrole for the antibiotic levofloxacin. Thin Solid Films 2012; 520; 1938–1943.
  • Tang L., Tong Y., Zheng R., Liu W., Gu Y., Li C., Chen R., Zhang Z. Ag nanoparticles and electrospun CeO2-Au composite nanofibers modified glassy carbon electrode for determination of levofloxacin. Sens Actuat B Chem 2014; 203; 95–101.
  • Wen W., Zhao D.M., Zhang X.H., Xiong H.Y., Wang S.F., Chen W., Zhao Y.D. One-step fabrication of poly(o-aminophenol)/multi-walled carbon nanotubes composite film modified electrode and its application for levofloxacin determination in pharmaceuticals. Sens Actuat B Chem 2012; 174; 202–209.
  • Tajabadi M.T., Sookhakian M., Zalnezhad E., Yoon G.H., Hamouda A.M.S., Azarang M., Basirun W.J., Alias Y. Electrodeposition of flower-like platinum on electrophoretically grown nitrogen-doped graphene as a highly sensitive electrochemical non-enzymatic biosensor for hydrogen peroxide detection. Appl Surf Sci 2016; 386; 418–426.
  • Ban F.Y., Jayabal S., Lim H.N., Lee H.W., Huang N.M. Synthesis of nitrogen-doped reduced graphene oxide-multiwalled carbon nanotube composite on nickel foam as electrode for high-performance supercapacitor. Ceram Int 2017; 43; 20–27.
  • Guo C.X., Li C.M. A self-assembled hierarchical nanostructure comprising carbon spheres and graphene nanosheets for enhanced supercapacitor performance. Energy Environ Sci 2011; 4; 4504-4507.
  • Yoo E.J., Kim J., Hosono E., Zhou H.S., Kudo T., Honma I. Large reversible Li storage of graphene nanosheet families for use in rechargeable lithium ion batteries. Nano Lett 2008; 8; 2277-2282.
  • Giannouri M., Bidikoudi M., Pastrana-Martínez L.M., Silva A.M.T., Falaras P. Reduced graphene oxide catalysts for efficient regeneration of cobalt-based redox electrolytes in dye-sensitized solar cells. Electrochim Acta 2016; 219; 258–266.
  • Mukdasai S., Langsi V., Pravda M., Srijaranai S., Glennon J.D. A highly sensitive electrochemical determination of norepinephrine using l-cysteine self-assembled monolayers over gold nanoparticles/multi-walled carbon nanotubes electrode in the presence of sodium dodecyl sulfate. Sens Actuat B Chem 2016; 236; 126–135.
  • Taei M., Salavati H., Hasanpour F., Habibollahi S., Baghlani H. Simultaneous determination of ascorbic acid, acetaminophen and codeine based on multi-walled carbon nanotubes modified with magnetic nanoparticles paste electrode. Mater Sci Eng C 2016; 69; 1–11.
  • Silva T.A., Zanin H., Vicentini F.C., Corat E.J., Fatibello-Filho O. Electrochemical determination of rosuvastatin calcium in pharmaceutical and human body fluid samples using a composite of vertically aligned carbon nanotubes and graphene oxide as the electrode material. Sens Actuat B Chem 2015; 218; 51-59.
  • Raj M.A., John S.A. Fabrication of Electrochemically Reduced Graphene Oxide Films on Glassy Carbon Electrode by Self-Assembly Method and Their Electrocatalytic Application. J Phys Chem C 2013; 117; 4326–4335.
  • Moraes F.C., Silva T.A., Cesarino I., Lanza M.R.V., Machado S.A.S. Antibiotic Detection in Urine Using Electrochemical Sensors Based on Vertically Aligned Carbon Nanotubes, Electroanalysis 2013; 25; 2092–2099.
  • Chi Y., Li J. Determination of levofloxacin hydrochloride with multiwalled carbon nanotubes-polymeric alizarin film modified electrode. Russ J Electrochem 2010; 46; 155–160.
  • Radi A., El Ries M.A., Kandil S. Electrochemical study of the interaction of levofloxacin with DNA. Anal Chim Acta 2003; 495; 61–67.
  • Borowiec J., Yan K., Tin C.C., Zhang J. Synthesis of PDDA Functionalized Reduced Graphene Oxide Decorated with Gold Nanoparticles and Its Electrochemical Response toward Levofloxacin J Electrochem Soc 2015; 162; H164–H169.
There are 23 citations in total.

Details

Subjects Engineering
Journal Section Articles
Authors

Ayça Atılır Özcan This is me

Mustafa Gürbüz This is me

Ali Özcan

Publication Date December 31, 2017
Published in Issue Year 2017 Volume: 18 Issue: 5

Cite

APA Atılır Özcan, A., Gürbüz, M., & Özcan, A. (2017). PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, 18(5), 962-972. https://doi.org/10.18038/aubtda.319445
AMA Atılır Özcan A, Gürbüz M, Özcan A. PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN. AUJST-A. December 2017;18(5):962-972. doi:10.18038/aubtda.319445
Chicago Atılır Özcan, Ayça, Mustafa Gürbüz, and Ali Özcan. “PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 18, no. 5 (December 2017): 962-72. https://doi.org/10.18038/aubtda.319445.
EndNote Atılır Özcan A, Gürbüz M, Özcan A (December 1, 2017) PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 18 5 962–972.
IEEE A. Atılır Özcan, M. Gürbüz, and A. Özcan, “PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN”, AUJST-A, vol. 18, no. 5, pp. 962–972, 2017, doi: 10.18038/aubtda.319445.
ISNAD Atılır Özcan, Ayça et al. “PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 18/5 (December 2017), 962-972. https://doi.org/10.18038/aubtda.319445.
JAMA Atılır Özcan A, Gürbüz M, Özcan A. PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN. AUJST-A. 2017;18:962–972.
MLA Atılır Özcan, Ayça et al. “PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, vol. 18, no. 5, 2017, pp. 962-7, doi:10.18038/aubtda.319445.
Vancouver Atılır Özcan A, Gürbüz M, Özcan A. PREPARATION OF A MODIFIED ELECTRODE FOR THE DETERMINATION OF LEVOFLOXACIN. AUJST-A. 2017;18(5):962-7.