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SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES

Year 2011, Volume: 1 Issue: 2, 137 - 8, 29.07.2011

Abstract

In the present study, a series of chalcones were prepared by Claisen Schmidt condensation as starting compounds and 2-pyrazoline derivatives have been synthesized by the reaction of chalcones with thiosemicarbazide. Their structures have been confirmed by IR, 1H-NMR, mass spectral data and elemental analysis. These synthesized 2-pyrazoline compounds have been tested in vivo anticonvulsant activity by using pentylenetetrazole (PTZ) induced seizure and maximal electroshock (MES) seizure
tests at a dose of 50 mg/kg. None of the compounds have in vivo anticonvulsant properties in PTZ test whereas some compounds showed in vivo anticonvulsant activity in MES test. Therefore, 2-pyrazoline compounds have a promising in vivo anticonvulsant activity especially on generalized absence seizures.

Yaşam Bilimleri ve Biyoteknoloji

Year 2011, Volume: 1 Issue: 2, 137 - 8, 29.07.2011

Abstract

Bu çalışmada, başlangıç maddesi olarak bir seri şalkon, Claisen Schmidt kondensasyonu kullanılarak hazırlanmış ve bu şalkonların tiyosemikarbazid ile reaksiyonu sonucu 2-pirazolin türevleri sentezlenmiştir. Bileşiklerin kimyasal yapıları IR, 1H-NMR ve kütle gibi spektral yöntemler ve elementel analiz yöntemi kullanılarak kanıtlanmıştır. Sentezlenen bu 2-pirazolin türevlerinin in vivo antikonvulsan aktiviteleri, pentilentetrazol (PTZ) ve maksimal elektroşok (MES) ile uyarılmış nöbetlere karşı 50 mg/kg dozda test edilmiştir. Hiçbir bileşik PTZ testinde herhangi bir in vivo antikonvulsan özellik göstermemesine karşın, bazı bileşikler MES testinde in vivo antikonvulsan aktivite göstermişlerdir. Dolayısıyla 2-pirazolin türevleri özellikle generalize absens nöbetlerine karşı ümit verici in vivo antikonvulsan aktiviteye sahiptirler

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Details

Primary Language English
Journal Section Articles
Authors

Bedia Koçyiğit-kaymakçıoğlu

Elçin Oruç-emre This is me

Nagihan Beyhan This is me

Hale Toklu This is me

Salih Gümrü This is me

Feyza Arıcıoğlu This is me

Publication Date July 29, 2011
Published in Issue Year 2011 Volume: 1 Issue: 2

Cite

APA Koçyiğit-kaymakçıoğlu, B., Oruç-emre, E., Beyhan, N., Toklu, H., et al. (2011). SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology, 1(2), 137-8.
AMA Koçyiğit-kaymakçıoğlu B, Oruç-emre E, Beyhan N, Toklu H, Gümrü S, Arıcıoğlu F. SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology. July 2011;1(2):137-8.
Chicago Koçyiğit-kaymakçıoğlu, Bedia, Elçin Oruç-emre, Nagihan Beyhan, Hale Toklu, Salih Gümrü, and Feyza Arıcıoğlu. “SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES”. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 1, no. 2 (July 2011): 137-8.
EndNote Koçyiğit-kaymakçıoğlu B, Oruç-emre E, Beyhan N, Toklu H, Gümrü S, Arıcıoğlu F (July 1, 2011) SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 1 2 137–8.
IEEE B. Koçyiğit-kaymakçıoğlu, E. Oruç-emre, N. Beyhan, H. Toklu, S. Gümrü, and F. Arıcıoğlu, “SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES”, Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology, vol. 1, no. 2, pp. 137–8, 2011.
ISNAD Koçyiğit-kaymakçıoğlu, Bedia et al. “SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES”. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 1/2 (July 2011), 137-8.
JAMA Koçyiğit-kaymakçıoğlu B, Oruç-emre E, Beyhan N, Toklu H, Gümrü S, Arıcıoğlu F. SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology. 2011;1:137–8.
MLA Koçyiğit-kaymakçıoğlu, Bedia et al. “SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES”. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology, vol. 1, no. 2, 2011, pp. 137-8.
Vancouver Koçyiğit-kaymakçıoğlu B, Oruç-emre E, Beyhan N, Toklu H, Gümrü S, Arıcıoğlu F. SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology. 2011;1(2):137-8.