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SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION

Year 2019, Volume: 61 Issue: 1, 24 - 32, 30.06.2019
https://doi.org/10.33769/aupse.467095

Abstract

In this study, the
emergences of postsynaptic action potentials are investigated using simulation
study which is depended on the statistical model of acetylcholine (Ach) quantal
release theory at motor end-plate. It is supposed that the end-plate potentials
(EPP) are sum of miniature end-plate potentials (MEPP) which are released as
quantal and random in number (N). By the hypothesis that N number has a Poisson
and MEPPs have a Gaussian distribution,  EPPs
are obtained by simulating distributions parameters. Our study suggests that
the simulation of the EPPs are  a
convenient tool  in understanding both
physiological process of synaptic transmission 
and pathological process of neuromuscular junction.



 

References

  • [1]- Neural Signaling. In: Dale Purves, George Augustine, David Fitzpatrick, William Hall, Anthony-Samuel Lamantia, Leonard White Neuroscience. 5th Edition.
  • [2]- Dale HH, Feldberg W, and Vogt M (1936) Release of acetylcholine at voluntary motor nerve endings. J Physiol 86:353–380
  • [3]- Fatt P, Katz B. An analysis of the end-plate potential recorded with an intra-cellular electrode. J Physiol. 1951;115:320–370.
  • [4]- del Castillo J, Katz B. Quantal components of the end-plate potential. J Physiol. 1954;124:560–573.
  • [5]- Tuckwell, HC. Elemantary Aplications of Probability Theory, Chapman & Hall, 1995.
  • [6]- Tuckwell, HC. Stochastic Proseses in the neuroscience, The Society for Industrial and Applied Mathemetics, 1994.
  • [7]- Öztürk, F. and Özbek L. Matematiksel Modelleme ve Simülasyon, 2016.
Year 2019, Volume: 61 Issue: 1, 24 - 32, 30.06.2019
https://doi.org/10.33769/aupse.467095

Abstract

References

  • [1]- Neural Signaling. In: Dale Purves, George Augustine, David Fitzpatrick, William Hall, Anthony-Samuel Lamantia, Leonard White Neuroscience. 5th Edition.
  • [2]- Dale HH, Feldberg W, and Vogt M (1936) Release of acetylcholine at voluntary motor nerve endings. J Physiol 86:353–380
  • [3]- Fatt P, Katz B. An analysis of the end-plate potential recorded with an intra-cellular electrode. J Physiol. 1951;115:320–370.
  • [4]- del Castillo J, Katz B. Quantal components of the end-plate potential. J Physiol. 1954;124:560–573.
  • [5]- Tuckwell, HC. Elemantary Aplications of Probability Theory, Chapman & Hall, 1995.
  • [6]- Tuckwell, HC. Stochastic Proseses in the neuroscience, The Society for Industrial and Applied Mathemetics, 1994.
  • [7]- Öztürk, F. and Özbek L. Matematiksel Modelleme ve Simülasyon, 2016.
There are 7 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Review Articles
Authors

Levent Özbek 0000-0003-1018-3114

Çağrı Temucın 0000-0003-0127-6861

Bülent Cengız 0000-0002-1688-9516

Fikri Özturk This is me 0000-0002-7175-7372

Publication Date June 30, 2019
Submission Date October 3, 2018
Acceptance Date February 23, 2019
Published in Issue Year 2019 Volume: 61 Issue: 1

Cite

APA Özbek, L., Temucın, Ç., Cengız, B., Özturk, F. (2019). SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION. Communications Faculty of Sciences University of Ankara Series A2-A3 Physical Sciences and Engineering, 61(1), 24-32. https://doi.org/10.33769/aupse.467095
AMA Özbek L, Temucın Ç, Cengız B, Özturk F. SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION. Commun.Fac.Sci.Univ.Ank.Series A2-A3: Phys.Sci. and Eng. June 2019;61(1):24-32. doi:10.33769/aupse.467095
Chicago Özbek, Levent, Çağrı Temucın, Bülent Cengız, and Fikri Özturk. “SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION”. Communications Faculty of Sciences University of Ankara Series A2-A3 Physical Sciences and Engineering 61, no. 1 (June 2019): 24-32. https://doi.org/10.33769/aupse.467095.
EndNote Özbek L, Temucın Ç, Cengız B, Özturk F (June 1, 2019) SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION. Communications Faculty of Sciences University of Ankara Series A2-A3 Physical Sciences and Engineering 61 1 24–32.
IEEE L. Özbek, Ç. Temucın, B. Cengız, and F. Özturk, “SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION”, Commun.Fac.Sci.Univ.Ank.Series A2-A3: Phys.Sci. and Eng., vol. 61, no. 1, pp. 24–32, 2019, doi: 10.33769/aupse.467095.
ISNAD Özbek, Levent et al. “SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION”. Communications Faculty of Sciences University of Ankara Series A2-A3 Physical Sciences and Engineering 61/1 (June 2019), 24-32. https://doi.org/10.33769/aupse.467095.
JAMA Özbek L, Temucın Ç, Cengız B, Özturk F. SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION. Commun.Fac.Sci.Univ.Ank.Series A2-A3: Phys.Sci. and Eng. 2019;61:24–32.
MLA Özbek, Levent et al. “SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION”. Communications Faculty of Sciences University of Ankara Series A2-A3 Physical Sciences and Engineering, vol. 61, no. 1, 2019, pp. 24-32, doi:10.33769/aupse.467095.
Vancouver Özbek L, Temucın Ç, Cengız B, Özturk F. SYNAPTIC TRANSMISSION: A MODEL ON THE FORMATION OF END-PLATE POTENTIAL AND A STUDY ON SIMULATION. Commun.Fac.Sci.Univ.Ank.Series A2-A3: Phys.Sci. and Eng. 2019;61(1):24-32.

Communications Faculty of Sciences University of Ankara Series A2-A3 Physical Sciences and Engineering

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