A VİTAMİNİNİN NON-ALKOLİK YAĞLI KARACİĞER HASTALIĞINDAKİ ROLÜ

Year 2020, Volume: 9 Issue: 1, 168 - 175, 30.06.2020

Sümeyye Güzel , Nucan Yabancı Ayhan

Abstract

Temel
bir mikro besin ögesi olan A vitamini, karaciğerdeki glukoz ve lipid
homeostazının düzenlenmesi dahil olmak üzere çeşitli fizyolojik fonksiyonlarda
kritik rol oynamaktadır. A vitamini vücutta temel olarak karaciğerdeki pasif hepatik
yıldız hücrelerde (HYH) depolanır. Hepatositler A vitaminini metabolize eder ve
A vitamini metabolitlerine yanıt olarak glukoz ve lipid metabolizması değişikliğinde
rol oynar. Ancak aktif hale getirilmiş HYH'ler A vitamini içeriklerini kaybeder
ve karaciğer yağlanmasının alkol tüketimine bağlı olmayan türü olan non-alkolik
yağlı karaciğer hastalığı (NAYKH) gelişmesine neden olur. Bu derlemede, NAYKH 'de
A vitamini metabolizması ve karaciğer hastalığının ilerlemesindeki olası rolü
ile birlikte A vitamini metabolitlerinin terapötik potansiyelinin
değerlendirmesi amaçlanmıştır. 

Keywords

A vitamini, non-alkolik yağlı karaciğer hastalığı, retinol, retinoik asit

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