Research Article
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Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study

Year 2024, Volume: 77 Issue: 4, 397 - 403, 31.12.2024

Abstract

Objectives: Heavy metal and solvent exposure is an important occupational hazard that causes serious health problems in industrial workers. This
study aimed to evaluate radiological abnormalities in patients diagnosed with occupational heavy metal and solvent toxicity.

Materials and Methods: Retrospectively, 962 male patients between the ages of 18 and 64 who were diagnosed with heavy metal and solvent
toxicity between 2018 and 2020 were examined. Radiological evaluations were performed with posterior-anterior chest radiography, high-resolution
computed tomography of the thorax, abdominal radiography and abdominal ultrasonography. Abnormal findings were systematically recorded and
analyzed.

Results: Emphysema was detected in 29.6% of the patients, hepatosteatosis in 58.1% and osteoporosis in 14.2%. These rates are higher than
the rates in the general population. Additionally, 10.2% of patients had a reticulonodular pattern suggestive of pneumoconiosis, while 6.1% had
gallbladder polyps.

Conclusion: This study demonstrates severe pulmonary, hepatic, and skeletal abnormalities in workers exposed to heavy metals and solvents. The
findings highlight the need for stricter occupational safety regulations, preventive strategies, and regular health screenings for workers at risk.
Future studies should focus on prospective studies that include both male and female individuals to understand the long-term effects of these toxic
exposures.

Ethical Statement

This study was conducted retrospectively and received approval from the Clinical Research Ethics Committee of the University of Health Sciences Türkiye, Keçiören Training and Research Hospital

Supporting Institution

-

Project Number

-

Thanks

-

References

  • 1. Rehman K, Fatima F, Waheed I, et al. Prevalence of exposure of heavy metals and their impact on health consequences. J Cell Biochem. 2018;119:157-184.
  • 2. van Valen E, Wekking E, van Hout M, et al. Chronic solvent-induced encephalopathy: course and prognostic factors of neuropsychological functioning. Int Arch Occup Environ Health. 2018;91:843-858.
  • 3. Lin CH, Lai CH, Peng YP, et al. Comparative health risk of inhaled exposure to organic solvents, toxic metals, and hexavalent chromium from the use of spray paints in Taiwan. Environ Sci Pollut Res Int. 2019;26:33906-33916.
  • 4. Fu Z, Xi S. The effects of heavy metals on human metabolism. Toxicol Mech Methods. 2020;30:167-176.
  • 5. Brauner C, Joveleviths D, Álvares-da-Silva MR, et al. Exposure to organic solvents and hepatotoxicity. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2020;55:1173-1178.
  • 6. Kurt OK, Basaran N. Occupational exposure to metals and solvents: allergy and airway diseases. Curr Allergy Asthma Rep. 2020;20:38.
  • 7. Alif SM, Dharmage S, Benke G, et al. Occupational exposure to solvents and lung function decline: a population based study. Thorax. 2019;74:650-658.
  • 8. Kawada T. Occupational heavy metal exposures and kidney dysfunction. Biol Trace Elem Res. 2020;194:1-2.
  • 9. Hwang S, Lee KJ, Park JB. Pulmonary function impairment from exposure to mixed organic solvents in male shipyard painters. J Occup Environ Med. 2018;60:1057-1062.
  • 10. Suganuma N, Yoshida S, Takeuchi Y, et al. Artificial intelligence in quantitative chest imaging analysis for occupational lung disease. Semin Respir Crit Care Med. 2023;44:362-369.
  • 11. Rabiei P, Ferguson EC, Hanna MF, et al. Imaging in occupational and environmental lung disease. Curr Pulmonol Rep 2020;9:63-73.
  • 12. Carroll MB, Kanne JP. Imaging of occupational and environmental lung disease. Semin Respir Crit Care Med. 2022;43:874-886.
  • 13. Kim KI, Kim CW, Lee MK, et al. Imaging of occupational lung disease. Radiographics. 2001;21:1371-1391.
  • 14. Nemery B. Metal toxicity and the respiratory tract. Journal of Occupational Medicine. 1990;32:1157
  • 15. Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73-84.
  • 16. Martins AC, Ferrer B, Tinkov AA, et al. Association between heavy metals, metalloids and metabolic syndrome: new insights and approaches. Toxics. 2023;11:670.
  • 17. Kratzer W, Haenle MM, Voegtle A, et al. Ultrasonographically detected gallbladder polyps: a reason for concern? A seven-year follow-up study. BMC Gastroenterol. 2008;8:41.
  • 18. Jalili C, Kazemi M, Taheri E, et al. Exposure to heavy metals and the risk of osteopenia or osteoporosis: a systematic review and meta-analysis. Osteoporos Int. 2020;31:1671-1682.
  • 19. Huang Z, Wang X, Wang H, et al. Relationship of blood heavy metals and osteoporosis among the middle-aged and elderly adults: A secondary analysis from NHANES 2013 to 2014 and 2017 to 2018. Front Public Health. 2023;11:1045020.
  • 20. Visconti VV, Gasperini B, Greggi C, et al. Plasma heavy metal levels correlate with deregulated gene expression of detoxifying enzymes in osteoporotic patients. Sci Rep. 2023;13:10641.
  • 21. Snega Priya P, Pratiksha Nandhini P, Arockiaraj J. A comprehensive review on environmental pollutants and osteoporosis: Insights into molecular pathways. Environ Res. 2023;237(Pt 2):117103.
  • 22. Silbergeld EK. Lead in bone: implications for toxicology during pregnancy and lactation. Environ Health Perspect. 1991;91:63-70.

Ağır Metal ve Solventlere Maruz Kalan Çalışanlarda Radyolojik Anormalliklerin Değerlendirilmesi: Tek Merkezli Bir Çalışma Hakan Baş1, Leyli Can Aynal2, Özgür Akkale3, Abdulsamet

Year 2024, Volume: 77 Issue: 4, 397 - 403, 31.12.2024

Abstract

Amaç: Ağır metal ve solvent maruziyeti, endüstriyel çalışanlarda ciddi sağlık sorunlarına yol açan önemli bir mesleki tehlikedir. Bu çalışmada, mesleki
ağır metal ve solvent toksisitesi tanısı alan hastalarda radyolojik anormalliklerin değerlendirilmesi amaçlanmıştı

Gereç ve Yöntem: Retrospektif olarak 2018-2020 yılları arasında ağır metal ve solvent toksisitesi tanısı alan 18-64 yaş arası 962 erkek hasta
incelendi. Radyolojik değerlendirmeler posterior-anterior akciğer grafisi, toraksın yüksek çözünürlüklü bilgisayarlı tomografisi, abdominal radyografi
ve abdominal ultrasonografi ile gerçekleştirildi. Anormal bulgular sistematik olarak kaydedildi ve analiz edildi.

Bulgular: Hastaların %29,6’sında amfizem, %58,1’inde hepatosteatoz ve %14,2’sinde osteoporoz tespit edilmiştir. Bu oranlar, genel popülasyondaki
oranlarından daha yüksektir. Ek olarak, hastaların %10.2’sinde pnömokonyozu işaret eden retikülonodüler patern saptanmış, %6,1’inde ise safra
kesesi polipleri bulunmuştur.

Sonuç: Bu çalışma, ağır metallere ve çözücülere maruz kalan çalışanlarda ciddi pulmoner, hepatik ve iskelet sistemi anormalliklerini ortaya
koymaktadır. Bulgular, risk altındaki çalışanlar için daha katı iş güvenliği düzenlemeleri, önleyici stratejiler ve düzenli sağlık taramalarına olan

Ethical Statement

This study was conducted retrospectively and received approval from the Clinical Research Ethics Committee of the University of Health Sciences Türkiye, Keçiören Training and Research Hospital

Supporting Institution

-

Project Number

-

Thanks

-

References

  • 1. Rehman K, Fatima F, Waheed I, et al. Prevalence of exposure of heavy metals and their impact on health consequences. J Cell Biochem. 2018;119:157-184.
  • 2. van Valen E, Wekking E, van Hout M, et al. Chronic solvent-induced encephalopathy: course and prognostic factors of neuropsychological functioning. Int Arch Occup Environ Health. 2018;91:843-858.
  • 3. Lin CH, Lai CH, Peng YP, et al. Comparative health risk of inhaled exposure to organic solvents, toxic metals, and hexavalent chromium from the use of spray paints in Taiwan. Environ Sci Pollut Res Int. 2019;26:33906-33916.
  • 4. Fu Z, Xi S. The effects of heavy metals on human metabolism. Toxicol Mech Methods. 2020;30:167-176.
  • 5. Brauner C, Joveleviths D, Álvares-da-Silva MR, et al. Exposure to organic solvents and hepatotoxicity. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2020;55:1173-1178.
  • 6. Kurt OK, Basaran N. Occupational exposure to metals and solvents: allergy and airway diseases. Curr Allergy Asthma Rep. 2020;20:38.
  • 7. Alif SM, Dharmage S, Benke G, et al. Occupational exposure to solvents and lung function decline: a population based study. Thorax. 2019;74:650-658.
  • 8. Kawada T. Occupational heavy metal exposures and kidney dysfunction. Biol Trace Elem Res. 2020;194:1-2.
  • 9. Hwang S, Lee KJ, Park JB. Pulmonary function impairment from exposure to mixed organic solvents in male shipyard painters. J Occup Environ Med. 2018;60:1057-1062.
  • 10. Suganuma N, Yoshida S, Takeuchi Y, et al. Artificial intelligence in quantitative chest imaging analysis for occupational lung disease. Semin Respir Crit Care Med. 2023;44:362-369.
  • 11. Rabiei P, Ferguson EC, Hanna MF, et al. Imaging in occupational and environmental lung disease. Curr Pulmonol Rep 2020;9:63-73.
  • 12. Carroll MB, Kanne JP. Imaging of occupational and environmental lung disease. Semin Respir Crit Care Med. 2022;43:874-886.
  • 13. Kim KI, Kim CW, Lee MK, et al. Imaging of occupational lung disease. Radiographics. 2001;21:1371-1391.
  • 14. Nemery B. Metal toxicity and the respiratory tract. Journal of Occupational Medicine. 1990;32:1157
  • 15. Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73-84.
  • 16. Martins AC, Ferrer B, Tinkov AA, et al. Association between heavy metals, metalloids and metabolic syndrome: new insights and approaches. Toxics. 2023;11:670.
  • 17. Kratzer W, Haenle MM, Voegtle A, et al. Ultrasonographically detected gallbladder polyps: a reason for concern? A seven-year follow-up study. BMC Gastroenterol. 2008;8:41.
  • 18. Jalili C, Kazemi M, Taheri E, et al. Exposure to heavy metals and the risk of osteopenia or osteoporosis: a systematic review and meta-analysis. Osteoporos Int. 2020;31:1671-1682.
  • 19. Huang Z, Wang X, Wang H, et al. Relationship of blood heavy metals and osteoporosis among the middle-aged and elderly adults: A secondary analysis from NHANES 2013 to 2014 and 2017 to 2018. Front Public Health. 2023;11:1045020.
  • 20. Visconti VV, Gasperini B, Greggi C, et al. Plasma heavy metal levels correlate with deregulated gene expression of detoxifying enzymes in osteoporotic patients. Sci Rep. 2023;13:10641.
  • 21. Snega Priya P, Pratiksha Nandhini P, Arockiaraj J. A comprehensive review on environmental pollutants and osteoporosis: Insights into molecular pathways. Environ Res. 2023;237(Pt 2):117103.
  • 22. Silbergeld EK. Lead in bone: implications for toxicology during pregnancy and lactation. Environ Health Perspect. 1991;91:63-70.
There are 22 citations in total.

Details

Primary Language English
Subjects Neurology and Neuromuscular Diseases
Journal Section Research Article
Authors

Hakan Baş 0000-0001-8641-843X

Leyli Can Aynal This is me 0000-0002-2555-5710

Özgür Akkale 0000-0003-4848-6014

Abdulsamet Sandal 0000-0002-9718-7769

Project Number -
Submission Date August 15, 2024
Acceptance Date December 12, 2024
Publication Date December 31, 2024
Published in Issue Year 2024 Volume: 77 Issue: 4

Cite

APA Baş, H., Can Aynal, L., Akkale, Ö., Sandal, A. (2024). Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 77(4), 397-403. https://doi.org/10.4274/atfm.galenos.2024.34635
AMA Baş H, Can Aynal L, Akkale Ö, Sandal A. Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study. Ankara Üniversitesi Tıp Fakültesi Mecmuası. December 2024;77(4):397-403. doi:10.4274/atfm.galenos.2024.34635
Chicago Baş, Hakan, Leyli Can Aynal, Özgür Akkale, and Abdulsamet Sandal. “Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77, no. 4 (December 2024): 397-403. https://doi.org/10.4274/atfm.galenos.2024.34635.
EndNote Baş H, Can Aynal L, Akkale Ö, Sandal A (December 1, 2024) Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77 4 397–403.
IEEE H. Baş, L. Can Aynal, Ö. Akkale, and A. Sandal, “Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 77, no. 4, pp. 397–403, 2024, doi: 10.4274/atfm.galenos.2024.34635.
ISNAD Baş, Hakan et al. “Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77/4 (December2024), 397-403. https://doi.org/10.4274/atfm.galenos.2024.34635.
JAMA Baş H, Can Aynal L, Akkale Ö, Sandal A. Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2024;77:397–403.
MLA Baş, Hakan et al. “Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 77, no. 4, 2024, pp. 397-03, doi:10.4274/atfm.galenos.2024.34635.
Vancouver Baş H, Can Aynal L, Akkale Ö, Sandal A. Evaluation of Radiological Abnormalities in Workers Exposed to Heavy Metals and Solvents: A Single-Center Study. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2024;77(4):397-403.