The Relationship Between Noise-Induced Occupational Sensorineural Hearing Loss and Platelet Panel: A Retrospective Study

Abstract

Objectives: There are various risk factors such as age, genetics, smoking, hypertension, diabetes mellitus, and vascular diseases that affect noiseinduced Occupational Sensorineural Hearing Loss (OSNHL). In addition to nerve damage, pathology may occur in the vascular and hematological structure of the cochlear system in sensorineural hearing loss. For this reason, we wanted to evaluate the relationship between platelet panel parameters and hearing loss. Materials and Methods: Socio demographic characteristics, audiometry results, platelet parameters, physical examination and admission complaints were collected in the data package by retrospectively scanning patient files. The patients were evaluated for the presence of OSNHL. Subgroup analysis was performed. Since all patients work in similar industrial environments, it was assumed that there would be a risk of noise in all of them. Results: The mean age of the patients was 40.0±8.3 (302 patients). Patients with OSNHL were older than those without hearing loss (43.5±8.0; 36.2±6.9 p<0.001). The ratio of male and female patients with OSNHL was 146/11, and 139/6 in those without hearing loss. Platelet count and plateletcrit values of patients with OSNHL were found to be higher and statistically significant (275.7±62.4, 245.1±42.0 p<0.001, 0.28±0.06; 0.25±0.04 p<0.001, respectively). There was no difference between mean platelet volume (MPV) values (10.4±0.8; 10.3±0.8 p=0.654). There was no significant correlation between age, smoking and platelet panel in patients with and without hearing loss (Pearson’s correlation analysis). Receiver operating characteristic analysis of thrombocyte counts, plateletcrit and MPV values of patients with hearing loss was performed [respectively; area under the curve (AUC)=0.64 (0.57-0.70 p<0.001), AUC=0.65 (0.58-0.71 p<0.001), AUC=0.52 (0.45-0.58 p=0.522)]. Conclusion: Platelet count and plateletcrit values are higher in patients with OSNHL than those without hearing loss, regardless of age and smoking.

Keywords

• Noise
• Platelet
• Plateletcrit
• Occupational
• Sensorineural Hearing Loss

Gürültüye Bağlı Mesleki Sensorinöral İşitme Kaybı ve Trombosit Paneli Arasında İlişki: Retrospektif Bir Çalışma

Abstract

Amaç: Gürültüye bağlı Mesleki Sensorinöral İşitme Kaybı’nı (MSNİK) etkileyen yaş, genetik, sigara, hipertansiyon, diabetes mellitus, vasküler hastalıklar gibi çeşitli risk faktörleri mevcuttur. Sensorinöral işitme kaybında sinir hasarının yanı sıra koklear sistemin vasküler yapısında da patoloji oluşabilir. Bu sebepten trombosit paneli parametrelerinin işitme kaybı ile ilişkisini değerlendirmek istedik. Gereç ve Yöntem: Hasta dosyaları geriye dönük taranarak sosyo-demografik özellikleri, odyometri sonuçları, trombosit parametreleri, fizik muayene ve başvuru yakınmaları veri paketinde toplandı. MSNİK tanısı almış ve almamış hastalar iki alt gruba ayrıldı. Tüm hastalar aynı ortamlarda çalıştığı için hepsinde gürültü riski olacağı varsayıldı. Bulgular: Hastaların ortalama yaşı 40,0±8,3 idi (toplam 302 hasta). MSNİK tanılı hastalar, işitme kaybı olmayanlara göre daha yaşlıydı (43,5±8,0; 36,2±6,9 p<0,001). MSNİK tanılı erkek ve kadın hasta oranı 146/11, işitme kaybı olmayanlarda ise 139/6 idi. MSNİK’li hastaların trombosit sayısı ve plateletkrit değerleri daha yüksek ve istatistiksel olarak anlamlı saptandı (sırasıyla, 275,7±62,4; 245,1±42,0 p<0,001, 0,28±0,06; 0,25±0,04 p<0,001). MPV değerleri arasında bir fark yoktu (10,4±0,8; 10,3±0,8 p=0,654). İşitme kaybı olan ve olmayan hastaların yaş/sigara ve trombosit paneli arasında yapılan Pearson korelasyon analizi anlamlı değildi. İşitme kaybı olan hastaların trombosit sayıları, plateletkrit ve MPV değerlerinin alıcı işlem karakteristikleri analizi yapıldı [sırasıyla; eğri altında kalan alan (AUC)=0,64 (0,57-0,70 p<0,001), AUC=0,65 (0,58-0,71 p<0,001), AUC=0,52 (0,45-0,58 p=0,522)]. Sonuç: MSNİK’li hastalarda trombosit sayımı ve plateletkrit değerleri yaş ve sigaradan bağımsız olarak işitme kaybı olmayanlara göre daha yüksek seyrediyor.

Keywords

• Gürültü
• Trombosit
• Plateletkrit
• Mesleksel
• Sensorinöral İşitme Kaybı

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