Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects

Şeyma Ertem; Mehmet Cüneyt Ensari; Özcan Erel

doi:10.4274/atfm.galenos.2022.24008

EN TR

Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects

Abstract

Objectives: We aimed to investigate the relationship between iron deficiency without anemia and thiol disulphide homeostasis, which effected oxidative status. Materials and Methods: A total of 71 cases, including the 5-15 age group with iron deficiency (n=35) and age- and gender-matched healthy control group (n=36), who applied to the pediatric outpatient clinic, were enrolled in the study. The diagnosis of iron deficiency was established for the patients who had normal hemoglobin levels considering age and gender, and whose ferritin value was <12 ng/mL. Results: Ferritin levels were 11.01±0.89 ng/mL in patients with iron deficiency and 25.27±2.57 ng/mL in healthy controls (p<0.001). In patients with iron deficiency, native thiol and total thiol levels were significantly lower (p<0.001 and p<0.001, respectively), and disulphide, disulphide/native thiol ratio and disulphide/total thiol ratio were significantly higher (p<0.001, p<0.001 and p<0.001, respectively). Only total thiol levels had positive correlation with ferritin levels (r=0.330, p=0.049). Conclusion: In this study, we showed that iron deficiency has effect on oxidative stress.

Keywords

Iron Deficiency, Oxidative Stress, Thiol Disulphide Homeostasis

Demir Eksikliği Tespit Edilip Anemi Tespit Edilmeyen Hastalar ile Yaş Uyumlu Sağlıklı Kontroller Arasındaki Enflamasyon ve Oksidatif Durumu Gösteren Hematolojik ve Biyokimyasal Parametrelerin Karşılaştırılması

Abstract

Amaç: Anemi olmadan demir eksikliği olan hastalar ile oksidatif durumu etkileyen tiyol disülfid dengesi arasındaki ilişkinin ortaya konulması amaçlanmıştır. Gereç ve Yöntem: Pediatri polikliniğinde başvuran 5-15 yaş aralığı demir eksikliği (n=35) olan grup ile yaş ve cinsiyet uyumlu sağlıklı kontrol grubunun (n=36) oluşturduğu toplam 71 olgu çalışmaya dahil edildi. Demir eksikliği tanısı, yaş ve cinsiyete göre normal hemoglobin seviyesine sahip olup, ferritin değeri <12 ng/mL altında olan hastalara konuldu. Bulgular: Demir eksikliği grubunda ferritin düzeyi 11,01±0,89 ng/mL iken, kontrol grubunda ise 25,27±2,57 ng/mL idi (p<0,001). Demir eksikliği grubunda nativ tiyol ve total tiyol değerleri anlamlı olarak düşükken (p<0,001 ve p<0,001, sırasıyla), disülfid, disülfid/nativ tiyol ve disülfid/total tiyol değerleri anlamlı olarak yüksekti (p<0,001, p<0,001 ve p<0,001, sırasıyla). Ferritin düzeyi ile sadece total tiyol düzeyi arasında pozitif korelasyon mevcuttu (r=0,330, p=0,049). Sonuç: Bu çalışmada anemi olmadan da demir eksikliğinin oksidatif strese neden olduğu izlendi.

Keywords

Demir Eksikliği, Oksidatif Stres, Tiyol Disülfid Dengesi

Ethical Statement

31.11.2015 tarihli Ufuk Üniversitesi Yerel Etik Kurul kararı ile “5-15 yaş DE tespit edilip anemi tespit edilmeyen hastalar ile yaş uyumlu sağlıklı kontroller arasındaki enflamasyon ve oksidatif durumu gösteren hematolojik ve biyokimyasal parametrelerin karşılaştırılması” isimli çalışma etik kurulca incelenerek uygun bulunmuştur (karar no: 31.11.2015).

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Details

Primary Language

English

Subjects

Paediatrics (Other)

Journal Section

Research Article

Authors

Şeyma Ertem
0000-0002-8958-5935
Türkiye

Mehmet Cüneyt Ensari This is me
0000-0002-9151-962X
Türkiye

Özcan Erel
0000-0002-2996-3236
Türkiye

Publication Date

October 18, 2022

Submission Date

February 20, 2021

Acceptance Date

July 20, 2022

Published in Issue

Year 2022 Volume: 75 Number: 3

DOI

https://doi.org/10.4274/atfm.galenos.2022.24008

IZ

https://izlik.org/JA86HU97ZL

APA

Ertem, Ş., Ensari, M. C., & Erel, Ö. (2022). Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 75(3), 462-467. https://doi.org/10.4274/atfm.galenos.2022.24008

AMA

1.Ertem Ş, Ensari MC, Erel Ö. Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022;75(3):462-467. doi:10.4274/atfm.galenos.2022.24008

Chicago

Ertem, Şeyma, Mehmet Cüneyt Ensari, and Özcan Erel. 2022. “Comparison of Hematological and Biochemical Parameters Which Indicate Inflammatory and Oxidative Status Between Pediatric Patients With Iron Deficiency But Without Anemia and Age-Matched Healthy Subjects”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75 (3): 462-67. https://doi.org/10.4274/atfm.galenos.2022.24008.

EndNote

Ertem Ş, Ensari MC, Erel Ö (October 1, 2022) Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75 3 462–467.

IEEE

[1]Ş. Ertem, M. C. Ensari, and Ö. Erel, “Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 75, no. 3, pp. 462–467, Oct. 2022, doi: 10.4274/atfm.galenos.2022.24008.

ISNAD

Ertem, Şeyma - Ensari, Mehmet Cüneyt - Erel, Özcan. “Comparison of Hematological and Biochemical Parameters Which Indicate Inflammatory and Oxidative Status Between Pediatric Patients With Iron Deficiency But Without Anemia and Age-Matched Healthy Subjects”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75/3 (October 1, 2022): 462-467. https://doi.org/10.4274/atfm.galenos.2022.24008.

JAMA

1.Ertem Ş, Ensari MC, Erel Ö. Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022;75:462–467.

MLA

Ertem, Şeyma, et al. “Comparison of Hematological and Biochemical Parameters Which Indicate Inflammatory and Oxidative Status Between Pediatric Patients With Iron Deficiency But Without Anemia and Age-Matched Healthy Subjects”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 75, no. 3, Oct. 2022, pp. 462-7, doi:10.4274/atfm.galenos.2022.24008.

Vancouver

1.Şeyma Ertem, Mehmet Cüneyt Ensari, Özcan Erel. Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022 Oct. 1;75(3):462-7. doi:10.4274/atfm.galenos.2022.24008

Comparison of Hematological and Biochemical Parameters which Indicate Inflammatory and Oxidative Status Between Pediatric Patients with Iron Deficiency but Without Anemia and Age-matched Healthy Subjects

Abstract

Keywords

Demir Eksikliği Tespit Edilip Anemi Tespit Edilmeyen Hastalar ile Yaş Uyumlu Sağlıklı Kontroller Arasındaki Enflamasyon ve Oksidatif Durumu Gösteren Hematolojik ve Biyokimyasal Parametrelerin Karşılaştırılması

Abstract

Keywords

Ethical Statement

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