İntravenöz ve Subkütan İmmünoglobulin Replasman Tedavisi Kullanan Hastalarda Sağlık Durumu ve Yaşam Kalitesinin Değerlendirilmesi

Abstract

Objectives: Health-related quality of life (HRQoL) is an emerging field of research in primary immunodeficiency (PID) patients. PID patients’ quality of life worsens as a result of their considerable disease load causing limited capacity to work and attend school, as well as participation in routine physical activities. The aim of this study was to analyze the demographics, treatment satisfaction, treatment-related side effects, health status and HRQoL of adult PID patients using different immunoglobulin replacement methods. Materials and Methods: In this prospective, cross-sectional research, 53 adult patients, who had been diagnosed with PID and treated with IgRT, were included. The Euro-QOL 5-D (EQ-5D) and Medical Outcomes Study Short Form-36 (SF-36) scales were used to evaluate health status and HRQoL. Results: The study included 53 patients with a median age of 32 (IQR: 24-45) years. Thirty-three (62.2%) patients were female. Twenty-three individuals received intravenous immunoglobulin (IVIG) and 30 subcutaneous immunoglobulin (SCIG). There was no significant difference in side effects between SCIG and IVIG. According to the EQ-5D results, anxiety/depression was the most problematic area to deal with. Patients’ median SF-36 scores were significantly lower (p<0.005) than healthy Turkish population norms in all categories (except for mental health). For physical functioning, physical role difficulty, emotional role difficulty, and vitality, the median scores of the SCIG group were similar to those of the healthy population. Conclusion: Given that individuals receiving SCIG therapy have a comparable quality of life as the general population, employing SCIG in appropriate and chosen patients may improve quality of life by allowing patients to be more independent. Patients with PIDs should have regular HRQoL assessments to ensure that they are receiving sufficient psychosocial care.

Keywords

• : Health Status
• Quality of Life
• Primary Immunodeficiency
• IVIG
• SCIG

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