Production of Graphene Oxide/Poly (Lactic Acid)-Based Nanofibers for Neural Regeneration

Year 2018, Volume: 71 Issue: 3 , 177 - 180 , 31.12.2018

Hayriye Öztatlı Duygu Ege

https://izlik.org/JA62WK59RK

Abstract

Objectives: Peripheral nerve injury is a serious health problem and it significantly affects the patients’ quality of life. Short gap of the peripheral
nerve damage recover very slowly and if the gap between transected nerve ends is large, self- recovery becomes impossible. Hence, repair and
regeneration strategies of peripheral nerve injuries have taken a great deal of consideration.

Materials and Methods: In this study, a novel neural scaffold was produced by combining graphene oxide (GO) with polylactic acid (PLLA) to
produce electrospun nanofibers to enhance physical, chemical and biological properties of currently used scaffolds.

Results: The produced GO/PLLA nanofibers had a tensile modulus of 381 MPa and 10 MPa tensile strength. These values were found to be similar
to the mechanical properties of peripheral nerve tissue. Biocompatibility studies also demonstrated that the produced biomaterials contributed to
nerve tissue growth.

Conclusion: This study shows that GO/PLLA based nanofibers show potential for the regeneration of nerve tissue.

Keywords

Peripheral Nerve , Tissue Engineering , Electrospinning , Graphene Oxide , Poly (Lactic Acid

Ethical Statement

Ethics Committee Approval: Since human or animal experiment have not been done in this study; ethical instution name, approval number and patient approval have not been received. Informed Consent: Since human or animal experiment have not been done in this study; ethical instution name, approval number and patient approval have not been received. Peer-review: Internally peer-reviewed. Authorship Contributions Surgical and Medical Practices: H.Ö., D.E., Concept: H.Ö., D.E., Design: H.Ö., D.E., Data Collection or Processing: H.Ö., D.E., Analysis or Interpretation: H.Ö., D.E., Literature Search: H.Ö., D.E., Writing: H.Ö., D.E. Conflict of Interest: No conflict of interest was declared by the authors. Financial Disclosure: We thank to BAP (no:9940) for financial support to this study.

Project Number

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Grafen Oksit/Poli (Laktik) Asit Bazlı Nanofiberlerin Sinir Rejenerasyonu İçin Geliştirilmesi

https://izlik.org/JA62WK59RK

Abstract

Amaç: Periferal sinir hasarı ciddi bir sağlık sorunu olup hastanın hayat kalitesini ciddi olarak etkilemektedir. Periferal sinir hasarı çok yavaş iyileşir
ve iki sinir ucu arasında mesafe çoksa, hiç iyileşemez. Bu sebeple, sinir hasarının tedavisi için farklı stratejiler geliştirilmektedir. Bu çalışmalar
grafen oksit (GO)/polilaktik asit (PLLA) bazlı sinir iskelelerinin gelişmesini sağlamıştır. Bu iskeleler ile biyomalzemenin fiziksel, kimyasal ve biyolojik
özelliklerinin geliştirilmesi hedeflenmiştir.

Gereç ve Yöntem: Bu çalışmada, GO PLLA içerisine ilave edilmiştir ve elektroeğirme yöntemiyle matlar üretilmiştir. Daha sonra üretilen malzemelerin
mekanik özellikleri ve biyouyumlulukları test edilmiştir.

Bulgular: Üretilen GO/PLLA nanofiberler 381 MPa çekme modülüne ve 10 MPa çekme kuvvetine sahiptir. Bu değerler sinir dokusunun mekanik
özelliklerine çok yakındır. Biyoyumluluk çalışmaları da üretilen biyomalzemelerin sinir hücresi gelişimine katkı sağladığını göstermiştir.

Sonuç: Yapılan çalışmalar GO/PLLA bazlı nanofiberlerin sinir dokusu rejenerasyonu için ümit vaad ettiğini göstermiştir

Keywords

Periferik Sinir , Doku Mühendisliği , Elektroeğirme , Grafen Oksit , Poli (Laktik Asit)

Supporting Institution

-

Project Number

-

Thanks

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