Review

Protective Vaccine Researches in Shigella Infections

Volume: 8 Number: 4 June 3, 2012
Begüm Saran *
EN TR

Protective Vaccine Researches in Shigella Infections

Abstract

Shigella, a member of enterobacteriaceae, is endemic over the world and causes infections with high mortality rates especially in developing countries. Disease is more common among children under 5 years old and is an important cause of children death in world. World health organisation (WHO) consider the researches of a protective vaccine developement for shigellosis as a priority. Protective vaccines for Shigella infections are focused on conjugate vaccines based on bacterial O polysaccharide linked to a carrier protein administered by parenteral, oral or intranasal; live attenued vaccines conferring protection without causing disease; live oral vaccines obtained by genetic process following the discover of genes involved in pathogenesis; hybrid live vector Shigella vaccines; wide spectrum vaccines and invazincomplex vaccines. Last years, since virulance factors and pathogenesis of Shigella are discovered, promising vaccines for future are developed. In this review, vaccine developement strategies for obtaining protective and safe vaccines from past to now are investigated

Keywords

Shigella, Vaccine, researches

References

  1. 1. Dupont, HL. Shigella Species (Bacillary Dysentery). In: Mandell GL, Bennett JE, editors. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Philadelphia: Churchill Livingstone Elsevier.; 2010. p. 2905-2919.
  2. 2. Aysev AD. Shigella Türleri. In: Topçu AW, Söyletir G, Doğanay M, editors. İnfeksiyon Hastalıkları ve Mikrobiyolojisi, Etkenlere Göre İnfeksiyonlar. İstanbul: Nobel Tıp Kitapevleri.; 2008. p. 2164-2168.
  3. 3. Butler T, Scheld WM. Shigellosis. In: Goldman L, Ausiello D, editors. Cecil Textbook of Medicine. Philadelphia: Saunders.; 2004. p. 1852-1854.
  4. 4. Erdem B. Enterobacteriaceae. In: Mutlu G, İzmir T, Cengiz AT, Ustaçelebi Ş, Tümbay E, Mete Ö editors. Temel ve Klinik Mikrobiyoloji. Ankara: Güneş Kitabevi.; 1999. p. 471-515.
  5. 5. Black RE, Lanata CF. Diarrheal Diseases. In: Nelson KE, Williams CFM, editors. Infectious Disease Epidemiology: Theory and Practice. Massachusetts: Jones and Bartlett Publishers.; 2007. p. 759-786.
  6. 6. Levine MM, Kotloff KL, Barry EM, et al. Clinical Trials of Shigella Vaccines: Two Steps forward and One Step Back On a Long, Hard Road. Nat Rev Microbiol 2007;5(7): 540–553.
  7. 7. Ferreccio C, Prado V, Ojeda A, et al. Epidemiologic patterns of acute diarrhea and endemic Shigella infections in a poor periurban setting in Santiago, Chile. Am. J. Epidemiol 1991;134: 614–627 8. Tacket CO, Binion SB, Bostwick E, et al. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge. Am. J. Trop. Med. Hyg 1992;47: 276-283.
  8. 9. Kaminski RW, Oaks EV. Inactivated and subunit vaccines to prevent shigellosis. Expert Rev Vaccines 2009;8(12): 1693-1704.
  9. 10. Cohen D, Ashkenazi S, Green M, et al. Safety and immunogenicity of investigational Shigella conjugate vaccines in Israeli volunteers. Infect Immun 1996;64: 4074–4077.
  10. 11. Cohen D, Ashkenazi S, Green MS, et al. Double-blind vaccine-controlled randomised efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults. Lancet 1997;349(9046): 155-159.
APA
Saran, B. (2012). Protective Vaccine Researches in Shigella Infections. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 8(4), 105-110. https://izlik.org/JA39DT94UZ
AMA
1.Saran B. Protective Vaccine Researches in Shigella Infections. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2012;8(4):105-110. https://izlik.org/JA39DT94UZ
Chicago
Saran, Begüm. 2012. “Protective Vaccine Researches in Shigella Infections”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 8 (4): 105-10. https://izlik.org/JA39DT94UZ.
EndNote
Saran B (June 1, 2012) Protective Vaccine Researches in Shigella Infections. Ankara Üniversitesi Tıp Fakültesi Mecmuası 8 4 105–110.
IEEE
[1]B. Saran, “Protective Vaccine Researches in Shigella Infections”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 8, no. 4, pp. 105–110, June 2012, [Online]. Available: https://izlik.org/JA39DT94UZ
ISNAD
Saran, Begüm. “Protective Vaccine Researches in Shigella Infections”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 8/4 (June 1, 2012): 105-110. https://izlik.org/JA39DT94UZ.
JAMA
1.Saran B. Protective Vaccine Researches in Shigella Infections. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2012;8:105–110.
MLA
Saran, Begüm. “Protective Vaccine Researches in Shigella Infections”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 8, no. 4, June 2012, pp. 105-10, https://izlik.org/JA39DT94UZ.
Vancouver
1.Begüm Saran. Protective Vaccine Researches in Shigella Infections. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 2012 Jun. 1;8(4):105-10. Available from: https://izlik.org/JA39DT94UZ