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HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA/REPERFUSION INJURY

Year 2001, Volume: 54 Issue: 3, 414 - 424, 30.09.2001

Ümit Kaya

Abstract

In the experimentalIy focal cerebral ischemia/recirculation ischemia ,he effect ol intra arterial administration of the DMSO during the vecirculation period to ihe ischemic lesion field have been evaluated histonathologicaliy, in rabbits. DMSO administred during pecirculation period is found to be beneticial effect in reducing ischemia.

Keywords

Cerebral isehemia DSMO Recirculation.

References

  • Angel ME Ramesastry 5S Swartz WE Basford RE and Fuirell IW : Free Radicsls. Cencepts Conserning Their Chemisiry, Pathophysiology and Relevancs to Plastic Surgery. Plast, Reconstrüct. Sürg. 79 :6: 090-997, 1987. i
  • Bol 1 Zhu W : Hartley CJ Michael Ui et al ; Attenuation of Dysfontion in *&hs Postiseheimic Stunned 'Myocardium by Dimethyl Urea, Circulation 76 : 458- 408, 1SöT,
  • “De La Torre JC : Dimethyi Sulfoxide in Prostoğlandin-İromboxane and Platelet Systems after Cerebral Ischemia. Ann. NX Sgi., 411 : 293-308, 1983. *
  • Bulkley GB : Free Radical-Mediated Reperfusion Imjury : A Selective Review : Br. J. Canger (Supp) 8 : 66-73, İ987. : : e
  • Demopoules HB Flamm ES Pietronigro DD and Seligman ML : The Free Radical Pathology end the Microcirculatton in the Major Central Nervous System Disardörs, Acta Physiol. Scan 492 ; 91-120 ,1989,
  • Dujevı M Rozario R Dossovsky N Diaz FG and Segal R : Antiplatelet Effects of Dimethyi Sulfoxide, Barbituraleş, and Metyiprednisolone. Ann NY Acad Sci., 411 « 343-244, 1983.
  • Ikeda Y Anderson Jti Lang DM : Öxygen Free Radicals in the Genesis of Traumalice and Peritumoral Brain Oedemea, Neürosurgery 24 : 679-685, 1988.
  • Ikeda, Y and Kong DM : Comparative Effecis of Direct and Indirect Hidroxyl Badica 1Scavengers on Travumaltic Brain Oedemea : Acta Neuroch. (Supp) 5İ : 74-77, 1990.
  • Jerkins LW Povlishock JT Lewet W Miller JD Berker PP : The Role of Pos, üsehemic Recirculation in the Developmeny of Isehemic Neuronal Injury Following Caomnlete Cerebral isahemin. Acta Neuropathol. 55 : 205-220, 1981.
  • &edar J Jacop ET Bar-Natan N and Ravid M ; Dimethyl Sulfoxide in Acut Tsehemia of the Kidney. Ann. NY Acad Sci, :41: 131-134, 1983.
  • Kalimo H Paljarvi L Ölsson Y Siesjö BK : Structural Aspects of Energy Failure States in the Brain. In Wiedemann K., Hoyer S. (eds). Problems and Perspectives of Brain Protection. Springer, Berlin Heidelberg, New York 1983, pp : 1-11.
  • Kalimo H and Smith ML : Structural Aspect of Ischemic Brain Damage. Acta Neuroch. (Supp). 36 : 126-132, 1986,
  • Kharasch N Ihyagarsjan BS : Siructural Basis for Biological Activities of Dimetyl Sulfoxide. Ann. NY Acad. Sci, 411 : 391-402, 1983.
  • Kolp KH Jaenicke G Kramo: M et al : Absorgtion and Distribution and Elimination of Labeled Dimethy!i Sulloxide in Men and Animals, Ann, NY, Acad. Sci. 141 : 85, 1967.
  • Maurer P Möşvotwiz MA Levine L Melamed E : The Syntheşsi of Prostaglandings by Bovine Cerebrai Microvessels. Prostagl. Med. 4 : 153-161, 1980,
  • McCord JM : Oxygen Derived Fise Radicals in Postischemic Tissue İnjury, N. Eng, J, Med. 312 (3) : 159-163, 1985,
  • MeGraw CP : Treatment of Cerebral Infarction with Dimethyl Sulfoxide in the Mongolian Gerbil, Ann. NY Acad. Sci 411 : 278-283, 1983.
  • Pace DG Kovacş JL Klevans LR ; Dimetyl Sulfoxide Inhibits Ann, NY. Acad. Soi, 4l1 : 352-355, 1963.
  • Paker NB Bergen BM Curtis WE et al : Hidrogen Peroxidase Cause Dimethylthioureg Consumption while Hydrowyl Radical Causes Dimethyl Sulfoxide Consumption in Vitro. J. Free Radical Biol. Med. 1 ; 415-419, 1985.
  • Rosemblum W : Dimetyl Sulfoxide Effects on Platelet Aggregation and Vasculav Reaciivity in Pial Microcirculation. Ann NY Acad Sci. 411 : 110-118, 1983.

İSKEMİ/REPERFÜZYON ZEDELENMESİNDE INTRA ARTERİYEL VERİLEN DIMETİLSÜLFOKSİTİN ETKİSİNİN HİSTOPA'TOLOJİK OLARAK İNCELENMESİ

Year 2001, Volume: 54 Issue: 3, 414 - 424, 30.09.2001

Ümit Kaya

Abstract

Deneysel fokal serebral iskemi/resirkülasyon iskemisinde resirkülasyonla beraber intra arteriel olarak verilen DiMetil Sülfoksit (DMSO)'in lezyon bölgesine olan etkileri histopatolojik olarak incelenmiştir. Resirkülasyon periyodunda intra arteriyel olarak verilen DMSO'nun iskemik değişikliklerin azaltılmasında faydalı etkisi olduğu görülmüştür.

Keywords

Serebral iskemi DSMO Resirkülasyon.

References

  • Angel ME Ramesastry 5S Swartz WE Basford RE and Fuirell IW : Free Radicsls. Cencepts Conserning Their Chemisiry, Pathophysiology and Relevancs to Plastic Surgery. Plast, Reconstrüct. Sürg. 79 :6: 090-997, 1987. i
  • Bol 1 Zhu W : Hartley CJ Michael Ui et al ; Attenuation of Dysfontion in *&hs Postiseheimic Stunned 'Myocardium by Dimethyl Urea, Circulation 76 : 458- 408, 1SöT,
  • “De La Torre JC : Dimethyi Sulfoxide in Prostoğlandin-İromboxane and Platelet Systems after Cerebral Ischemia. Ann. NX Sgi., 411 : 293-308, 1983. *
  • Bulkley GB : Free Radical-Mediated Reperfusion Imjury : A Selective Review : Br. J. Canger (Supp) 8 : 66-73, İ987. : : e
  • Demopoules HB Flamm ES Pietronigro DD and Seligman ML : The Free Radical Pathology end the Microcirculatton in the Major Central Nervous System Disardörs, Acta Physiol. Scan 492 ; 91-120 ,1989,
  • Dujevı M Rozario R Dossovsky N Diaz FG and Segal R : Antiplatelet Effects of Dimethyi Sulfoxide, Barbituraleş, and Metyiprednisolone. Ann NY Acad Sci., 411 « 343-244, 1983.
  • Ikeda Y Anderson Jti Lang DM : Öxygen Free Radicals in the Genesis of Traumalice and Peritumoral Brain Oedemea, Neürosurgery 24 : 679-685, 1988.
  • Ikeda, Y and Kong DM : Comparative Effecis of Direct and Indirect Hidroxyl Badica 1Scavengers on Travumaltic Brain Oedemea : Acta Neuroch. (Supp) 5İ : 74-77, 1990.
  • Jerkins LW Povlishock JT Lewet W Miller JD Berker PP : The Role of Pos, üsehemic Recirculation in the Developmeny of Isehemic Neuronal Injury Following Caomnlete Cerebral isahemin. Acta Neuropathol. 55 : 205-220, 1981.
  • &edar J Jacop ET Bar-Natan N and Ravid M ; Dimethyl Sulfoxide in Acut Tsehemia of the Kidney. Ann. NY Acad Sci, :41: 131-134, 1983.
  • Kalimo H Paljarvi L Ölsson Y Siesjö BK : Structural Aspects of Energy Failure States in the Brain. In Wiedemann K., Hoyer S. (eds). Problems and Perspectives of Brain Protection. Springer, Berlin Heidelberg, New York 1983, pp : 1-11.
  • Kalimo H and Smith ML : Structural Aspect of Ischemic Brain Damage. Acta Neuroch. (Supp). 36 : 126-132, 1986,
  • Kharasch N Ihyagarsjan BS : Siructural Basis for Biological Activities of Dimetyl Sulfoxide. Ann. NY Acad. Sci, 411 : 391-402, 1983.
  • Kolp KH Jaenicke G Kramo: M et al : Absorgtion and Distribution and Elimination of Labeled Dimethy!i Sulloxide in Men and Animals, Ann, NY, Acad. Sci. 141 : 85, 1967.
  • Maurer P Möşvotwiz MA Levine L Melamed E : The Syntheşsi of Prostaglandings by Bovine Cerebrai Microvessels. Prostagl. Med. 4 : 153-161, 1980,
  • McCord JM : Oxygen Derived Fise Radicals in Postischemic Tissue İnjury, N. Eng, J, Med. 312 (3) : 159-163, 1985,
  • MeGraw CP : Treatment of Cerebral Infarction with Dimethyl Sulfoxide in the Mongolian Gerbil, Ann. NY Acad. Sci 411 : 278-283, 1983.
  • Pace DG Kovacş JL Klevans LR ; Dimetyl Sulfoxide Inhibits Ann, NY. Acad. Soi, 4l1 : 352-355, 1963.
  • Paker NB Bergen BM Curtis WE et al : Hidrogen Peroxidase Cause Dimethylthioureg Consumption while Hydrowyl Radical Causes Dimethyl Sulfoxide Consumption in Vitro. J. Free Radical Biol. Med. 1 ; 415-419, 1985.
  • Rosemblum W : Dimetyl Sulfoxide Effects on Platelet Aggregation and Vasculav Reaciivity in Pial Microcirculation. Ann NY Acad Sci. 411 : 110-118, 1983.
There are 20 citations in total.

Details

Primary Language English
Subjects Brain and Nerve Surgery (Neurosurgery)
Journal Section Research Article
Authors

Ümit Kaya

Publication Date September 30, 2001
Published in Issue Year 2001 Volume: 54 Issue: 3

Cite

APA Kaya, Ü. (2001). HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA/REPERFUSION INJURY. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 54(3), 414-424.
AMA Kaya Ü. HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA/REPERFUSION INJURY. Ankara Üniversitesi Tıp Fakültesi Mecmuası. September 2001;54(3):414-424.
Chicago Kaya, Ümit. “HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA REPERFUSION INJURY”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 54, no. 3 (September 2001): 414-24.
EndNote Kaya Ü (September 1, 2001) HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA/REPERFUSION INJURY. Ankara Üniversitesi Tıp Fakültesi Mecmuası 54 3 414–424.
IEEE Ü. Kaya, “HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA/REPERFUSION INJURY”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 54, no. 3, pp. 414–424, 2001.
ISNAD Kaya, Ümit. “HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA REPERFUSION INJURY”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 54/3 (September2001), 414-424.
JAMA Kaya Ü. HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA/REPERFUSION INJURY. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2001;54:414–424.
MLA Kaya, Ümit. “HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA REPERFUSION INJURY”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 54, no. 3, 2001, pp. 414-2.
Vancouver Kaya Ü. HISTOPATHOLOGICAL INVESTIGATION OF THE EFFECT OF INTRA-ARTERIALLY GIVEN DIMETHYLSULPHOXIDE ON ISCHEMIA/REPERFUSION INJURY. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2001;54(3):414-2.