Evaluation of Cerebral ischemia in Rabbits With Transient/Permanent Middle Cerebral Artery Occlusion Via Transorbital Approach. Technical and Pathological Evaluation. Part |.

Year 1991, Volume: 44 Issue: 3, 389 - 402, 30.09.1991

Ümit Kaya

https://izlik.org/JA57MK86XN

Abstract

To investigate brain ischemia, it is considered to be very difficult to develop a model in which controled regional brain ischemia can be achieved. Choosing the model, way of anesthesia, surgical method, to occlude just one artery, human like parencyhmal lesions are the main points that must be taken into consideration. In this experiment the right middle cerebral arteries of the rabbits have been occluded through transorbital approach. In a tota! number of 24 rabbits (weights, ranging between 2.5-3.0 kg) under general anesthesia, in different periods cerebral ischemia has been developed. The macroscopic and microscopic examination of the coroner sections of the pieces revealed that after an ischemic period of 4 hours and 2 recirculation period of 2 hours, a lesion that can be examined histologically can be
achieved. It is suggested that such a model can be used in the investigation of the effects of various drugs to the neuronal changes in the ischemic region.

Keywords

Cerebral ischemia , Middle cerebral artery , Transorbital approach.

Ethical Statement

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Thanks

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Tavsanlarda Transorbital Yolla Geciei/Kaler Orta Serebral Arter Trkanmast

https://izlik.org/JA57MK86XN

Abstract

Beyin iskemilerini arastirmak Uzere, bir model tzerinde kontrol edilebilir bélgesel iskemik lezyon gelistirilmesi bir cok sorunu da beraberinde tasimaktadir. Model secimi, anestezi kullanimi, kullanilan yontem, tek arter tikanmasi, gelisen parenkimal lezyonlarin insandakine benzer olmasi dikkate alinmasi gereken ézelliklerdendir, Bu deneyde transorbital yolla tavsanlarin sag orta serebral arterleri tikanmistir. Toplam 24 tavsanda (agirliklar 2.5-3.0 kg) genel anestezi altinda, cesitli zaman dilimleri icinde serebral iskemi olusturulmustur. Koroner kesit elde edilen kesilerin makroskopik ve mikroskopik incelemelerinden 4 saatlik bir siire ve 2 saatlik resirktlasyon sonunda histolojik olarak degerlendirilebilecek 6zellikleri olan iskemik bir alan olustugu gézlenmistir, Bu modelin cesitli ilaglarin, iskemi sonrasinda gelisen néronal degisiklikler Uzerine olan etkisini incelenmesinde kullaniabilinecegi belirlenmistir.

Keywords

Serebral iskemi , orta serebral arter , Transorbital yaklasim.

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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