Blood Leukocyte Ratios: Equivocal Parameters for Allergic Diseases

Year 2025, Volume: 78 Issue: 1, 13 - 19, 31.03.2025

Alper Ekinci Seda Altıner

Abstract

Objectives: Leukocytes play crucial roles in allergic and immunologic diseases. We compared neutrophil-lymphocyte ratio (NLR), basophillymphocyte ratio (BLR), eosinophil-neutrophil ratio (ENR), and eosinophil-lymphocyte ratio (ELR) in 100 drug-induced urticaria-angioedema, 100 drug/venom-triggered anaphylaxis cases, and 100 healthy controls to assess their association with the severity of the allergic reaction.

Materials and Methods: Retrospective analysis of blood leukocyte counts and ratios was performed.

Results: Median NLR was 1.975 in patients (2.09 in urticaria-angioedema, 1.905 in anaphylaxis) and 1.815 in controls. NLR was significantly higher in patients (p=0.038) and notably elevated in urticaria-angioedema (p=0.008). No significant differences in NLR were found between the urticaria-angioedema and anaphylaxis groups (p=0.09) or between the anaphylaxis and control groups (p=0.342). Other leukocyte ratios showed no significant changes between patient and control groups (p>0.05).

Conclusion: NLR may indicate allergic responses but doesn’t have predictive value for reaction type or severity.

Keywords

Anaphylaxis , angioedema , inflammation , leukocyte , urticaria

Ethical Statement

Ethics Committee Approval: Prior to commencing the research, necessary approval was obtained from the Human Research Ethics Committee of Ankara University (approval number: i09-647-23, date: 02.11.2023). Informed Consent: Informed consent has been obtained from the participants. The investigation adhered to the Helsinki Declaration in its conduct.

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Kan Lökosit Oranları: Alerjik Hastalıklar için Şüpheli Parametreler

Abstract

Amaç: Lökositler, alerjik ve immünolojik hastalıklarda önemli roller oynar. Nötrofil-lenfosit oranı (NLR), bazofil-lenfosit oranı (BLR), eozinofilnötrofil oranı (ENR) ve eozinofil-lenfosit oranı (ELR) ölçümlerini, 100 ilaçla tetiklenen ürtiker-anjioödem, 100 ilaç/venom ile tetiklenen anafilaksi olgusu ve 100 sağlıklı kontrol olgusunda karşılaştırarak bu oranların alerjik reaksiyonun şiddeti ile ilişkilerini değerlendirmeyi amaçladık.

Gereç ve Yöntem: Kan lökosit sayıları ve oranlarının retrospektif analizi gerçekleştirildi.

Bulgular: Hastalarda median NLR değeri 1,975 idi (ürtiker-anjioödem grubunda 2,09, anafilaksi grubunda 1,905), kontrol grubunda ise 1,815 olarak belirlendi. NLR, hasta grubunda anlamlı derecede yüksekti (p=0,038) ve özellikle ürtiker-anjioödem grubunda belirgin şekilde yükselmişti (p=0,008). Ürtiker-anjioödem ve anafilaksi grupları arasında (p=0,09) ve anafilaksi ile kontrol grupları arasında (p=0.342) NLR değerlerinde anlamlı fark bulunmadı. Diğer lökosit oranları, hasta ve kontrol grupları arasında anlamlı değişiklikler göstermedi (p>0,05).

Sonuç: NLR, alerjik reaksiyonlar için bir belirteç olabilir, ancak reaksiyon türü veya şiddeti için öngörü değeri bulunmamaktadır.

Keywords

Anafilaksi , anjioödem , enflamasyon , lökosit , ürtiker

Ethical Statement

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