Malign Hastalıklarda -Lipitler ve Lipoproteinlerin Immün Sisteme Etkisi
Abstract
Histopatolojik olarak malignite tanısı almış 31 hasta ve 20 sağlıklı kişilerde, serumda lipid elektroforezi, kolesterol, lipid, trigliserid miktarları, E rozet testi, serum immünglobulinleri seviyeleri, lenivent yüzey immtnglobülinleri incelendi. {ki grubun. karşılaştırılmasında alfa lipoprotein (HDL), E rozet testi, slgA degerlerinin hasta grupta, kontrollerden anlamlı derecede farkli olduğu bulundu. Immiinolojik parametrelerden bazılari ile lipidler ve lipoproteinler arasında ilişki arandı. E rozet ile prebeta (VLDL) arasında negatif, VLDL ile slgA arasında pozitif bir korelasyon bulundu. Literatürde de bunu destekleyen yayımlarım olması nedeniyle VLDL’nin immiumodepressan olma ihtimalini düşündük.
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References
- Barclay, M, Skipski, V.P., Terebesus-Kekish, O., Greene, M. : Effect of cancer upon high-density and other lipoproteins, Cancer Res, 30 : 2420-2430, 1970.
- 2. Bellanti, J.A. : Immunology I]. WB Saunders Company, 1978, § ; 161, 459. Ben-Bassat, I, Many, A.. Modan, M.: Serum immunglobulins in chronic lymp- _.hocytic leukemia. Am. J. Med, Sci. 278 : 4-9, 1979.
- 4, Bowman, W.P., Melvin, S., Mauer, A.M. : Cell markers in lymphomas and leukemias, Adv, Intern. Med. 25 : 391-425, 1980.Malign Hastaltklarda - Lipidler ve Lipoproteinlerin immiin Sisteme Etkisi "127 Broitman, S.A., Vitale, J.J. : Polyunsaturated fat, cholesterol and large bowel tumorigenesis.
- 5. Cancer, 40 : 2455-2463, 1977. - Burchard, H. : Chem. Zbl. 61 : 25, 1890. Chisari, F.V., Edgington, T.S. : Lymphocyte E rosette inhibitory factor : A regulatory serum lipoprotein. J. Exp. Med., 142 : 1092-1105 ,1975. Chisari, F.V. : : Immunoregulatory properties of human ne in very ‘low density lipoproteins. J. Immunol., 199 : 2129-2135, 1977. 6.Curtiss, L.K., De Keer, D.H., Edgington, T.S. : Influence of the immunoregulatory serum lipoprotein LDL-In on the in vivo proliferation and differantiation of antigen-binding and antibody-secreting lymphocytes during a primary immune response. Cell. Immunol., 49 : 1-11, 1980. Curtiss, L.K., Edgington, T.S. : Immunoregulatory plasma low density lipoprotein :
- 7. The biologic activity and receptor-bindings specificity is independent of the neutral lipids. J. Immunol. 126 : 1008-1012, 1981. Durrum, E.L., Paul, M.H. and Smith, E.R.B.: Science. 116 : 428, 1952. Edgington, T.S., Curtiss, L.K. : Plasma lipoproteins with bioregulatory properties including the capacity to regulate lymphocte function and the immune response. Cancer Res., 41 : 3786-3788, 1981.
- 8.Heiniger, H.J.: Cholesterol and its biosynthesis in normal and malignant lymphocytes. Cancer Res., 41 : 3792-3794, 1981.
- 9.Huber, L.A. et al. : Immunoregulatory properties of human low and high density ipoproteins, immunobiology, 175 : 265-266, 1987. Liebermann, C. ; Chem. Ber, 18 : 1803, 1885. 10.Lobo, P.J., Westervett, B., Horwitz, D. : Identification of two populations of immunoglobulin-bearing lymphocytes in man. J. Immunol. 114 : 116-126, 1975. Nydegeger, U.E., Butler, R.E. : Serum lipoprotein levels in patients with cancer Cancer Res., 32 : 1656-1760, 1972.
- 11.Opat, P., Kolar, V. : Humoral and cellular immunity in long term survivingpatients with malignant lymphoma. Neoplasma, 27 ; 301-305, 1990. Reid, M.M., Craft, A.W. : Immunoglobulin concentrations in children receiving treatment for acute lymphoblastic leukemia. J. Clin. Pathol. 34 : 479-482, 1981.
- 12.Royer, M.E., Ko, H. : Anal. Biochem. 29 : 405, 1969. Royston, L, Dillman, R., Jaffe, E, : Cell-surface markers in lymphoproliferative disease. N. Engl. J. Med., 21 : 1802-1304, 1981, Schein, P.S. ; Oncolipids?, N. Engl. J. Med., 315 : 1410-1411, 1986. Slater, G., Papatestas, A.E. : Serum immunoglobulins in colorectal cancer. JJ. Surg. Oncol., 14: 167-171, 1980. Stites, D., Stobo, J, Wells, J.V. : Basic and Clinical Immunology, Lange Medical
- 13.Publications, 1987, p : 27, 186, 249, 290.25. Townes, AS., Proslethwaite, AE, : Lymphocyte surface markers in human disease, Adv. Intern. Med., 22 : 97-115, 1977.