Insan Lokosıt Antıjenlerı Ve Perıyodık Hastalık

Year 1988, Volume: 41 Issue: 2, 195 - 210, 30.06.1988

Negüz Sümer

https://izlik.org/JA86FZ84JE

Abstract

One of the most remarkable discoveries in recent years is the involment of the major histocompatibility complex in immunologic reactions. set of The human leucocyte antigens (HLA) system represents a similar genes in man and comprises 5 closely linked genetic loci on chromosome 6. Transplantation antigens coded for the HLA-A, HLA-B, HLA-C, HLA-C and HLA-DR loci are readly idendified with the use of serologic technic. The connection with a particular HLA type may make it possible to In
distinguish different clinical forms of a disease. some disease the HLA region served as a genetic marker for recessive or dominantly inherid disease genes. Gen frequency and disease association differ in different geographic regions. In this investigation, we have come to conclusion that : Some of HLA antigens, A9, A10, Bis and B4o antigens showed a, relative risk, although it was at a lower rate, compared with the other types antigens. It will be possible to attain a more meaningful result as the number of cases increase.

Keywords

histokompatibilite , lékosit , relatif

Ethical Statement

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Supporting Institution

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Thanks

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Insan Lokosıt Antıjenlerı Ve Perıyodık Hastalık

https://izlik.org/JA86FZ84JE

Abstract

Major histokompatibilite kompleksi ile ilgili olarak yapilan calismalar son yillarin en 6nemli arastirmalarindan biri olmustur. insan lékosit antijenleri 6. kromozom tzerinde 5 ayrl lokusta bulunurlar. insan lékosit antijenlerinin baz tipleri ile bazi hastaliklar arasinda 6nemli yaklasimlar bulundugu anlasilmistir. Bu antijenler hastaligin genetik markeri olarak resesif veya dominant 6zelligini verir. Periyodik hastalikta yapilan bu calismada AQ, A10, B18 ve B40 gibi baz antijen tiplerinde relatif risk orani cok yüksek olmamakla birlikte anlamlı bulunmustur.

Keywords

histokompatibilite , lékosit , relatif

Ethical Statement

-

Supporting Institution

-

Project Number

-

Thanks

-

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