Laringoskopi Ve Trakeal Entübasyona Bağlı Kardiyovasküler Yanıtlara İntravenöz Lidokainin Etkisi

Year 1988, Volume: 41 Issue: 4, 611 - 628, 30.12.1988

Yeşim Batıislam

https://izlik.org/JA76FB75HH

Abstract

Bu klinik çalışma laringoskopi, trakeal entübasyon ve cilt insizyonuna bağlı hemodinamik yanıtların baskılanmasında intravenöz lidokainin etkinliğini saptamak amacı ile planlanmıştır. Elektif koroner arter bypass cerrahisi geçiren 18 hasta iki gruba ayrılmıştır : I. Grup, lidokain uygulanmayan kontrol grubunu, II. Grup ise entübasyondan Bu klinik çalışma laringoskopi, trakeal entübasyon ve cilt insizyonuna bağlı hemodinamik yanıtların baskılanmasında intravenöz lidokainin etkinliğini saptamak amacı ile planlanmıştır. Elektif koroner arter bypass cerrahisi geçiren 18 hasta iki gruba ayrılmıştır : I. Grup, lidokain uygulanmayan kontrol grubunu, II. Grup ise entübasyondan Bu yondan önce verilen lidokainin laringoskopi ve entübasyona bagli kardiyovasküler yarntlarl azalttlžl, ancak özellikle beta blokür alan veya miyokard reservi düsük hastalarda kardiyovasküler depresyona yol açabilecešini göstermektedir.

Keywords

entübaasyon , kardiyovasküler , lidokain

Laringoskopi Ve Trakeal Entübasyona Bağlı Kardiyovasküler Yanıtlara İntravenöz Lidokainin Etkisi

https://izlik.org/JA76FB75HH

Abstract

This clinical study was designed to évaluate the effect of intrave nous lidocaine in preventing hemodynamic responses to laryngoscopy, tracheal intubation and skin incision. Eighteen patients undergoing elective coronary artery bypass surgery were divided into two groups. Patients in Group I did not receive lidocaine (control group) while those in Group Il were given 1.5 mg/kg of intravenous lidocaine prior to intubation. The patients were anesthetized with high doses of mor phine-diazepam anesthesia and received beta blocking therapy until the day of surgery. Following laryngoscopy and tracheal intubation, patients in control group had significant (p <0.05) increases in heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, systolic pulmonary arterial pressure, diastolic pulmonary ar terial pressure, mean pulmonary arterial pressure, pulmonary capiller wedge pressure, central venous pressure as well as rate-pressure product and triple index which reflect myocardial oxygen consumption compaired •with patients given lidocaine. In contrast to these findings, lidocaine did not depress cardiovascular responses to skin incision. In addition, 1.5 mg/kg of lidocaine produced marked decreases in systolic blood pressure and mean arterial pressure. These results demonstra ted that lidocaine given before intubation attenuates cardiovascular responses to laryngoscopy and intubation, but can cause cardiovas cular depression, especially in patients receiving beta blocking drug or criticall yill patients with decreased myocardial reserve

Keywords

entübasyon , kardiyovasküler , lidokain

Ethical Statement

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Supporting Institution

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Thanks

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References

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