Oksijen, Papaverin, Insulin, Potasyum Ve Sodyum Bikarbonatın Kalbin Anoksi Toleransı Üzerine Etkisi

Year 1986, Volume: 39 Issue: 4 , 335 - 346 , 31.12.1986

Fevzi Akçay

https://izlik.org/JA22ZK46FB

Abstract

Kalbin anoksiye olan dayanıklılığı normotermik koşullarda «oksijen, papaverin, glikoz, insulin, potasyum ve sodyum bikarbonat» ın bileşik etkisi ile uzatılabilir. Bu uzatılma çalışan kalplerde X 27 oranına, çıkarılabilmiştir. Yirmiki köpekte anoksi boğma asfiksisi yöntemi ile yapıldı. Kontrol grubu olan 10 köpekte asfiksi oda havası oksijeni ile uygulandı, ve kalpler 7.90 £ 1.56 dakikada durdu. Oda havasına e kbir oksijenasyonu takiben papaverin, glikoz, insülin, potasyum ve bikarbonatın karışımı bir solüsyon verilen 12 köpekte ise kalpler 10.08 -- 2.36 dakikada durdu. Asfiksinin stres etkisi köpeklerde biperglisemi ve anaerob miyokart metabolizması koroner sinüste laktik asit oluşumunu yükseltir. Papaverin, glikoz, insulin, potasyum ve sodyum bikarbonatın açık kalp ameliyatlarında intrakoroner olarak injeksiyon veya kalp reanimasyonları sırasında intrakardiyak olarak
verilmesi miyokardı anoksiye karşı korur.

Keywords

anoksi , miyokard koroner , İskemik arrest

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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The Effect of Oxygen, Papaverin, insulin, Potassium and Sadium Bicarbonate on the anoxia Tolerance of the Heart

https://izlik.org/JA22ZK46FB

Abstract

Anoxia tolerance of the heart in normothermic condition may be prolonged by the combined effect of «oxygen, papaverin, glucose, insulin, potassium and sodium bicarbonate». This prolongation is about
27 & in working hearts. Anoxia is induced in 22 dogs by asphyxiation. In 10 of the control group, the hearts stopped in 7.09 X 1.56 minutes due to anoxia of asphyxiation in room air, In 12 of them, the solution
group, which recieved intracoronary papaverin, glucose, insulin, potassium and sodium bicarbonate mixture, following period of oxygenation, the hearts stopped in 10.08 X 2.36 minutes, Anaerobic myocardial metabolism causes increased lactic acid production in the coronary sinus and stressfull effect of asphyxia exeris hypergiycemia in dogs. Intracoronary injection of papaverin, glucose, insulin, potassium, bicarbonate during cardiac ressucitation cases supports the myocardium against anoxia.

Keywords

anoxia , myocardial coronary , ischemic arrest

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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