Koroner Arter Hastalıklarında Sol Ventrikül Sistol Sonu Basınç-Volüm Oranının Segmenîer Kontraksiyon Bozuklukları İle İlişkisiŞKİSİ

Year 1986, Volume: 39 Issue: 1, 35 - 46, 31.03.1986

Olcay Sağkan

https://izlik.org/JA99DU26AZ

Abstract

Bu çalışma 8 normal ile sol ventrikül duvarında yersel kontraksiyon bozukluğu gösteren 28 koroner arter hastasında yapıldı. Koroner arter hastalarında sistolik pik basınç-sistol sonu volüm (SPB/SSV) sistol sonu basınç-sistol sonu volüm (SSB/SŞV) oranları ile ejeksğyon fraksiyonunun (EF) normallere nazaran anlamlı derece de (Pİ 0.001); P2 0.001; B 0001) azaldığı görüldü. Koroner dama rhastalarmda, anormal kontraksiyon yapan segment yüzdesi (AKS 70) ile SPB/SSV, ssB/şsv ve EF arasında anlam11 (Pİ 0,001; P2 0,001; R 0.001) bir ilişkinin varolduğu bulundu. EF % 50'nin altında olan 19 68) olguda AKS % 'si % 20'njn üstünde, 3 (% 11) olguda ise % 20'nin altında idi. SPB/SSV oram 3'ün altında ve SSB/SSV oranı 2'nin altında olan 21 (% 75) olguda AKS % 'si % 20'nin üstünde; 2 (% 7) olguda ise % 20'nin altında bulundu. Böylece SPB'm, SSB yerine kullanılabileceği görüldü, Çalışmamızda, koroner arter hastalarında SPB/SSV ve SSB/SSV oranları ile sol ventrikül kontraktilite bozukluğu ve AKS Z'nin saptanabileceği sonucuna varıldı.

Keywords

ventrikül , sistol , fraksiyon

Ethical Statement

-

Supporting Institution

-

Project Number

-

Thanks

-

Relationship between Left Ventricular End-Systolic Pressure-Volume Ratio and Segmental Contraction Disorders in Coronary Artery Diseases

https://izlik.org/JA99DU26AZ

Abstract

The ratio of end•systolic pressure to end•systolic volume : The relationship of this ratio with the length of the abnormally contracting segments in patients with coronary artery disease Eight normal and 28 patients with coronary artery disease presenting abnormal left ventricular contraction were studied. İt was found that systolic peak pressure to end-systolic volume (SPP/ESV) and end-systolic pressure to end-systolic volüme (ESP/ ESV) ratios and ejection fraction (EF) decreased significantly in patients with coronary artery disease when compared with the normals (PI < 0.001; P2 < 0.001; -Pg < 0.001) respectively. In the coronary artery patients the percent of abnormally contracting segments (ACS % ) was compared statistically with SPP/ESV and ESP/ESV ratios and EF. Results were statistically significant (PI < 0.001; P2 < 0.001; P3 < 0.001). In 19 ( % 68) patients showing EF less than 0.50, ACS % was above 20 % and in 3 (11 70) patients it was less than 20 020. In 21 (75 % ) patients when the SPP/ESV ratio was less than 3 and the ESP/ESV ratio was less than 2 the ASC % was above 20 To; and in 2 (7 % ) patients was below 20 %. This showed that SPP may be used instead of ESP. It is estimated that in patients with coronary artery disease SPP/ ESV and ESP/ESV ratios are helpful in the estimation of the ACS % and by the way the impairement of the left ventricular contractility.

Keywords

ventrikül , sistol , fraksiyon

Ethical Statement

-

Supporting Institution

-

Project Number

-

Thanks

-

References

• 1. Borow M.K., Alexander N., Wynne J. : Sensitivity of end-systolic pressure vo lume relations to the inotropic state in humans. Circulation 65 : 988, 1982.
• 2. Carebello Be, Spann J.F. : The uses and limitations of end-systolic indexes of left ventricular function Circulation 65 ; 1059, 1984.
• 3. Dodge H.T. Sandler H., Ballew D.W. ve ark. : The use of biplane angiocardiog raphy for the measurement of left ventricular volume in man. Amor. Heart J. 60 : 762, 1960.
• 4. Dodge H.T., Sandler H., Baxley W.A. ve ark. Usefulness and limitations of radiographic methods for determining left ventricular volume. Amer. J. Cardiol. 18 : 10, 1986.
• 5. Field B.J., Russel R.O. Jr., Dowling J.T. ve ark Regional left ventricular performance in the year following myocardial infarction. Circulation 46 : 679, 1972,
• 6. Greene G.D., Carlishe R, Grant C. ve ark. : Estimation of left ventricular volume by one plane cineangiography. Circulation 35 : 61, 1967. 7. Grossman W., Eugene B., Mann T. ve ark. Contractile state of left ventricle in man as evaluated from-systolic pressure-volume relations. Circulation 56 845, 1977.
• 8. Harmen M.V., Heinle R.A., Klein M.D. ve ark. : Localized disorders in myocardial contraction, New Eng. J. Med. 277 : 222, 1967.
• 9. Holt J.P. : Regulation of the degree of emptying of the left ventricle by the force of ventricular contraction. Circ. Res. 5 : 281, 1957.
• 10. Iskandrian S.A., Hakkl H., Bemis E.C. ve ark. : Left ventricular end-systolic pressure-volume relation. A combined rädionuclide and hemodynamic study. Amer. J. Cardiol. 51 1057, 1983.
• 11. Mahler F., Cowell J.W., Ross J. Jr. : Systolic pressure-diameter relations in the normal conscious dog. Cardiovasc. Res. 9 : 447, 1975.
• 12. Mahler F., Ross J. Jr., O Bourke R.A. ve ark. : Effects of changes in preload, afterload and inotropic state on ejection and isovolumic phase measures of contractility in the conscious dog. Amer. J. Cardiol. 35 : 626, 1975.
• 13. Mehmel H., Stockins Ruffmann K. ve arlc. : Linearity of the end-systolic pressure-volume relationship in man and its sensitivity for assessment of left ventricular function. Circulation 63 : 1216, 1981.
• 14. Nivatpumin Katz S. Scheuzer J. ; Peak left ventricular systolic pressure end-systolic volume ratio. Sensitive detector of left ventricular disease. Amen J. Cardiol. 43 : 969, 1979.
• 15. Pairolero P.C., Hallerman F.J., Ellis F.H. : The left ventriculogram in experimental myocardial infarction, Radiology 95 : 331, 1970.
• 16. Sagawa K. : The end-systolic pressure-volume relation of ventricle Definition, modifications and clinical use. Circulation 63 : 1223, 1981.
• 17. Suga H., Sagawa K, Shoukas A.A. : Load idependence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ, Res. 32 : 314, 1973.
• 18. Sagawa K, Suga Ha, Shoukas A,A. ve ark. : End-systolic pressure volume ratio A new index of ventricular contractility. Amer. J. Cardiol. 40 : 748, 1977.
• 19. Sažkan O. ; Koroner damar hastalarmda sol ventrikül sistol sonu basmcm sistol sonu volüme oram. Ejeksiyon fralcsiyonu ile bu oranlann bažlantlsl A.Ü. TIP Fak. Mec. 35 : 25, 1982.
• 20. Sözütek Y. : Ekokardiyografik olarak mitral kapažl hareketlerinin koroner damar hastallklanndaki yeri (Doçentlik Tezi). Ankara 1978.
• 21. Slutsky R., Karlier J., Gerber K. ve ark. : Peak systolic blood pressure end-systolic volume ratio : Assessment at rest and during exercise in normal subjects and patients with coronary heart disease Amer. J. Cardiol. 46 813, 1980.
• 22. Suga H.. Sagawa K. : Instantaneous pressure-volume relationships and their ratio in the excised, supported canine left ventricle. Circ. Res. 35 : 117, 1974,
• 23. Suga H., Sagawa K., Kostiuk D, : Control of ventricular contractility assessed by the pressure-volume ratio. Cardiovasc. Res. 10 : 582, 1976.
• 24, Suga H., Yamakoshi K. q. Effects of stroke volume and velocity of ejection on end-systolic pressure of canine left ventricle. Circ. Res. 40 : 445, 1977.
• 25, Taylor R.R. : Active length-tension relations compared in isometric afterload and isotonic contractions of cat papillary muscle : Their dependence on inot ropic state. Circ. Res. 26 : 279, 1970,