Sistemik Lupus Eritematosusda Klinik Ve İmmunolojik Değişiklikler İle Prolaktin Düzeyi Arasındaki İlişki

Year 1985, Volume: 38 Issue: 4, 247 - 257, 31.12.1985

Neval Duman

https://izlik.org/JA66UC94KY

Abstract

Bu çalışma 17-44 yaşları arasında olan SLE'lu kadın hastada yapılınıştır. Hastalar klinik ve immunolojik yönden değerIendirildi ve serum anti-DNA, immunoglobulinler, serum kompleman düzeyleri ölçüldü ve protein elektroforezi yapıldı. Ayrıca serum prolaktin düzeyleri ölçülerek immunolojik parametrelerle arasmdaki iliski arastll'lldl. SLE remisyon ve aktivasyonunda serum prolaktin düzeyindeki deEisikliklerin rolü incelendi. Yalrnz hastallžln aktivasyonu ile aralannda pozitif iliski bulundu. Bu durum hiperprolaktinemi ile seyreden fakat SLE yönünden klinik ve immunolojik remisyonun görüldüžü gebelikteki dežisiklikler ile ters düsmektedir.

Keywords

kadın , elektroporez , prolaktin , hamile

Relationship Between Clinical and Immunological Changes and Prolactin Levels in Systemic Lupus Erythematosus

https://izlik.org/JA66UC94KY

Abstract

This study was performed on 30 female patients with SLE aged between 17-44 years old. Serum anti-DNA, immunoglobulines, serum complement levels were measured together with protein electrophoresis. The serum prolactine levels were also measured and correlated with immunological data during the activation and remission of SLE. There was a positive correlation in these cases in their active stage. These results were not in accordance with the findings observed during pregnancy in which a clinical and immunological remission was observed related to SLE together with hyperprolactinemia.

Keywords

female , electrophoresis , prolactine , pregnancy

References

• I. Ablin R.J. : Estrogen and Immunity. The Journal of Immunology Vol : 124, No. 6, 2992-2993, June 1980.
• 2. Amino N., Tanizawa 0., Miyai K., Tanaka, F., Hayashi, C, Kawashima M., Ichihara K. : Changes of Serum Immunoglobulins IgG, IgA, IgM* and IgE during pregnancy. Obstetrics and gynecology. Vol. 52, No. 4, 415-419, October 1978
• 3. Beeson P.B., MC. Dermott W., Wyngarden J.B. : Cecil Textbook of. Medicine. 1979.
• 4. Bulmer R., Hancock K.W. : Depletion of circulating T lymphocytes in pregnancy. Clin Exp. Immunol. 2 8: 302-305, 1977.
• 5. Burman K.D, Dimond R.C, Noel G.L„ Earll J.M., Frantz A.G., Wartofsky L. Klinefelter's syndrome : Examination of thyroid function and the TSH and RPL responses to thyrotropin releasing hormone. Journal of clinical endocrinology.
• 6. Cauter E.V., L'hermite M., Copinschi G., Refetoff S., Desir D, Robyn C. : Quan titative analysis of Spontaneous variations of plasma prolactin in normal men. Endocrinol Metab. 4 : 355-363, 1981.
• 7. Cousins L, Rigg L, Hollingsworth D. Meis P., Halberg F., Brink G. : Qualitative and quantitative assessment of the circadian rhythm of cortisol in pregnancy. Am J obstot ( ynecol vol. 135, No. 4, 411-479, February 198'
• 8. Devoe L.D„ Taylor R.L : Systemic lupu serythematosus in pregnancy. Am J. obstet Gynecol. vol. 135, No. 4, 473-476 October 1979.
• 9. Fabris Piantanelli L„ Muzzioli M. : Differenitial effect of pregnancy or gestagens on humoral and cell-mediated immunity. Clin. Exp. Immunol. 28 : 306-314, 1977.
• 10. Freedman O.S., Gold P. : Clinical Immunology. 1976.
• 11. Fudenberg H.H., Sites D.P., Caldwell J.L. : Basic and clincal Immunology 1976.
• 12. Gallery ED., Raftos J., Gyory A.Z., Wells J. V. : Prospective study of serum complement (C3 and C,) levels in normal human pregnancy. Aust. N.Z. J. Med. 11 : 243-245, 1981.
• 13. Holdstock G., Chastenay B., Krawitt EL. : Effects of testesterone, oestradiol and progesterone on immune regulation. Clin. Exp. Immunol 47 : 449456, 1982.
• 14. Lahita R.G., Bradlow H.L,. Kunkel, I-LG., Fishman J. : Alterations of estrogen metalism in systematic lupus erythematosus. Arthritis and Rheumatism. Vol. 22, No : 11, 1195-1198. November, 1979.
• 15. Lahita R.G., Bradlow L, Fisman J., Kunkel H.G. : Estrogen metabolism in systemic lupus erythematosus. Arthritis and Rheumatism. Vol. 25, No. 7. July 1982.
• 16. Ortiz-N.C., Le Roy. ESC. : The Coincidence of Klinefelter's syndrome and systemic lupus erythematosus. Arthritis Rheum. 12 : 241-246, 1966.
• 17. Pavia CS. : Pregnancy and Immunology The Journal of Immunology. Vol. 124, No. 6 June 1980.
• 18. Stern R, Fishman J., Brusman H., Kunkel H.G. : Systemic lupus erythematosus associated with Klinefelter's syndrome. Arthritis and Rheumatism. Vol. 20, 20.1, 18-21, January 1977.
• 19. Stites D.P., Pavia C.S., Clemens L.E., Kuhn R.W. : Immunologic regulation in pregnancy .Arthritis and Rheumatism. Vol. 22, No. 11, November, 1979.
• 20. Strel Kauskas A.J., Davies J., Dray S. : Longitudinal studies showing alterations in the levels and functional response of T and B lymphocytes in human pregnancy. Clin. Exp. Immunology. 32 : 513-539, 1978.
• 21. Talal. N : Sex steroid hormones and systemic lupus erythematosus. Arthritis and rheumatism vol. 24, No. 8, 1054-1056. August 1981.
• 22. Varner M.W., Meeha nR.T., Syrop G.H., Strottmann M.P., Goplerud C.P : Pregnancy in patients with systemic lupus erythematosus. Am. J. Obstet Gynecol. Vol. 145, No. 8, 1025-1037, April, 1983.