Lökotrienier; Oluşumları Ve Klinik Patolojideki Önemleri

Year 1983, Volume: 36 Issue: 1, 115 - 132, 31.03.1983

Melih Melli

Abstract

Lökotrienlerin Üretimi ve Patolojik Durumlara Katılımları
Bu makalede yazar, vücutta araşidonik 2Cid'in lipooksijenaz ürünleri olan lökotrienlerin üretimi ve klinikopatolojik durumlardaki olası önemleri ile ilgili literatür verilerini gözden geçirmektedir.

Keywords

lökotren , araşidonik , lipooksijenaz

LEUKOTRIENIA; THEIR FORMATION AND IMPORTANCE IN CLINICAL PATHOLOGY

Abstract

production of Leukotrienes and Their Participations to pathological Conditions
In this article the author is reviewed the literature data concerning the production of lipooxygenase products of arachidonic 2Cid, leukotrienes, in the body and their possible significance in clinico-pathological conditions.

Keywords

leukotriene , arachidonic , lipoxygenase

References

• 1. Harkavy, J. : Spasm-producing substance in sputum of patients with bronchial astma. Arch. Int. Med d5 : 641-646, 1930
• 2, Kellaway, C.H.» Trethewie, E.R. Liberation of slow-reacting smooth muscle-stimuta- ting substance in anaphylaxis. Quart. J, Exper. Physiol. 30 : 121-145, 1940.
• 3. Brocklehurst, WE : Occurence of an .unidentified substance during anaphylactic shock in cavy lung. J. Physíol. CLöndon). 120 : 16P-17P, 1953.
• 4. Orange, R.P., Murpy, R.C., Austen, K.F. t Inactivation of slow-reacting substance of anaphylaxis (SRS-A) by arylsulfatases, Immunol. 113 : 316-322, 1974,
• 5. Orange, R.P., Murpy, R.C., Karnovsky, M.L., Austen, K.F. : The physicochemical cha racteristics and purification of slow.reacting substance of anaphylaxis. 5. Immunol. 110 160-720, 1973.
• 6. Koopman, W..1., Orange, R.r., Austen, K.F. : Prostaglandin inhibition of the immuno logic release of slow-reacting substance of anaphylaxis in the rat. Proc. Soc. Exp. Biol. Med,, 137 64-67, 1971,
• 7. Tauber, Al., Kaliner, M., Stechschulte, J., KF. : Immunologic release of histamine and slow-reacting substance of anaphylaxis from human lung. J. Immunol. 111 : 27-32, 1973.
• 8. Trethgwie, E.R. : Influence of sodium and acetyl salicylic acid on release of histamine in anaphylaxis. Australian. J, Exper. Biol. and M.Sc. 29 : 443-450, 1951.
• 9. Engineer, D.M., Piper, P.S., Sirois, P, : Interaction between the release of SRS-A and prostaglandins. Br, J. Tharrnnc. 57 : 460P-461P, 1976.
• 10. Dawson, W., Tomlinson, R. ; Effect of cromoglycate and eicosatetraynoic acid on the release of prostaglandins and SRS-A from immunologically chalenged quinea- pig lungs. J. Pharmac., 52 1079-108P,A974.
• 11. Jakschic, B,, Parker, C. : Probable precursor role of arachidonic acid in slow-reacting substance (SRS) biosynthesis, Clin. Res. 24 : 575, A, 1976
• 12. Jakschic. B., Falkenheim S., Parker, C.W. : Precursor role of arachidonic acid in slowreacting substance release from rat basophilic leukemia cells, proc. Natl. Acad. Sci. 74 : 4577-4581, 1977,
• 13, Bach, M.K., Brushlcr, J.R., Gorman, R.R. ; On the stnlcture of slow-reacting substance of anaphylaxis, Evidence of biosynthesis from arachidonie acid. Prostaglandins 14 21-38, 1977.
• 14. Stechschulte, D.S•, Austen, K E, Bloch, K.J. : Antibodies involved in antigen-induced release Of slow-reacting substance of anaphylaxis (SRS-A) in the quinea pig and rat. J. Exp. Med. 125 : 127-147, 1967.
• 15, Orange, R.P., Valentiiie, M.D., Austen, K.F• Antigen induced of slow-reacting substance Of anaphylaxis (SRS-A rat) in rats prepared with homologous antibody J. Exp. Med, 127 : 767-782, 1968.
• 16. Morris, H.R., Taylor, G.W., Piper, P.S., Sirois, P., Tippins, J.R. : Slow-reacting substance of •anaphylaxis and characterisation. FEBS Letters, 203-206, 1978.
• 17, Borgeat, P., Samuelsson, B.J, : Metabolism of arachidonic acid in polymorphonuclear Leucocytes. Structural analýsis Of novel hydroxylated compounds. J. Biol, Chem. 254 : 7865-7869, 1979.
• 18. Murphy, R.C., Hammarströrn, S, Samuelson, B., Leukotriene, C. : a slow-reacting substance from murine mastocytoma cells. Proc. NatlL Acad. Sci. 76 : 4275-4279, 1979
• 19. Lewis, R.A., Austen, KY., Drazen, J.M., Clark, D.A., Marfat, Corey, E.I. : Slowreacting substances of anaphylaxis : identification of leukotrienes C-1 and D from human and rat sources. Proc. Natl. Acad. sci. 77 : 3710-3714, 1980
• 20. Lewis, R.A., Drazen, J.M., Austen, K,F•, Clark, D.A., Corey, E.I. : Identification of the C (6)-S- conjugate of leukotriene A with,eysteine as naturally occurring slow-reacting substance of anaphylaxis (SRS-A), Importance "Of the Il-Cis geometry for biological activitiy, Bioehem. Biophys- Res. Commun. 96 : 271,277, 19SO•
• 21. Ellis, F., Mills, L.S„ North, P.C. : total synthesis of leukotriene (LTFD Tetrahedron Letters. 23 3735-3736, 1982.
• 22. Lewis, R.R., -Austen, K.F. Mediation of local homeostasis and inflammation by leukotrienes mid Other mast cell-dependent compounds, -Nature 293 103-109, 1981.
• 23. Samuelson, B.i Hammarström, S, : Nomenclature for leukotnenes. Prostaglandins. IY : 645-648, 1980.
• 24. Vane, J.R. : Inhibition of prostaglandin synthesis as a mechanism of action for the Aspirin-like drugs. Nature (London). 231 : 232-235, 1971.
• 25. Higgs, G.A„ Harvey; EA., Ferreira, S.E-L, Vane, J.R. : The effects of antiinflamatory drugs on the oroduction of prostaglandins in viyo. Advances in Prostaglandin and throm- boxane Vol- 1 105-110 (Eds Samuelson, n , ûetti, R.) Raven Press, New York, 1976
• 26, Walkert J.R., Smith, M.J .H., Ford-Hutchinson, A.W. Antiinflamatory drugs, Pros landins and leucocyte migråtion. Agents and Actions. 6 ; 602-606, 1976.
• 27. Ford-Hutchinson, A.w., Walker, J.R., Connor, N.s„ Oliver, A.M., Smith, M.J.H. : Se parate anti-inflamatory effects of indomethacin, flurbiprofen and Benoxaprofen. J Pharm. Pharmac. 29 372-373, 1977.
• 28. Eakins k,E., Higgs, GA., S" Mugçidge, K.G., Vane, J•R. The effects of indomethacin and BW 755 D C on leukocyte migration and prostaglandin production in carrageenan-induced intlammationw Br. J. Pharmac, 69 270 P-271P, 1980.
• 29. Higgs, G,A., Flower, R.J., Vane, JR ; New approach to anti-inflammatory agugs Biochem. Pharmac. 28 : 1959-1961, 1979.
• 30. Adcock, J.J., Garland, L.G, : possible role for lipoxygemse products as regulators of airway smooth muscle reactivity. Br. J. Pharmac, 69 : 167-169,
• 31. Morris, H.R., Piper, P.J., Taylor, G w. Tippins, J.R. ; The effect of arachidonate Lipoxygenase substrates and inhibitors on- SRS-A release in the guinea-pig lung, Br. J. Pharmac. 66 ; 452P, 1979.
• 32. Hamberg, M. : On the formation of and acid in tissues from the guinea-pig. Biochem. Biophys, Aeta. 431 ; 651-654, 1976.
• 33. Adccck, J•J,. Garland, , Moncada, S.. Salmon, LA, s: The mechanism of enhancement by fatty acid hydropero¥ides of anaphylactic mediator release. Prostaglandins. 16 : 179-187, 1978.
• 34. Siegel, M.I„ Mc Connell, R. Cuatrecases, p. Aspirin-like drugs interfere with arachidonate metabolism by inhibition Of the acid petoxtdase activity of the lipoxygenase pathway. Proc. Natl. Acad. Sci. 76 : 37743778, 1979.
• 35. Siegel, M.I., MC Connell, R.T., Porter, Cuetreacasas, P. : Arachidonate meta. bolism via lipoxygenase and 12-L-hydroperoxy-5,8, 10, 14-eicosatetraenoic acid percxidase sensitive to anti-inflammatory drugs. Proc. Natl. Acad. Sci. 77 : 308-312, 1980 3778, 1979.
• 36. Siegel, M.I., Mc Connell, RT., Porter, N.A., selph, J.L, Truaxt J.F., Vinegar' R., Cnat recasas P., : Aspirin-like drugs inhibit araehidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates. Bioehcm. Biophys. Res Commun. 92 : 688-695, 1980.
• 37. Moncada g., R.S., S, Vane, S.R. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (Prostaghndin X) which prevents platelet aggregation. Prostaglandins. 12 : 715-733, 1976.
• 38. Ham, EA., Egan, R.WI, Soderman, DD., Gale, P.H„ Kuehl, F.A. : Peroxidase-depen dent deactivation of prostacyciin synthetase, 5, Chem. 254 2191-2194,
• 39. Kcmariya, K., Ohmori, Azuma, IV, Kurazurni, S. et all. : PG12 as tt potentiator of acute inflammation in rats. Prostaglandins. 15 t 557-564, 1978.
• 40. Bragt, P.C., Bonta, L.L. : Indomethacin inhibits the in vivo formation of the lipoxygenase product HETE acid) during granulomatous inflammation in the rat, J. Pharm, Pharmacol. 32 : 143-144, 1980.
• 41. Vargaftig B.B.t Lefort, JA : Acute hypotension due to carrageenan, arachidonic acid and slowvreactíng subsumce in the rabbit Role of platelets and nature of pharmacological antagonism. Eur. J. Pharmacol. 43 : 125-141, 1977.
• 42. Vargaftigì B.BG : Salicylic acid fails to inhibit generation of TxA2 activity after in vivo adminístration to the rat. J. Pharrn• Pharmacol. 30 : 101-104, 1978.
• 43. Siegel, M .1., Me Connell, R.T.s Abrahams, S.L., Porter, N.A., Cuctrecasas, P. : Regulation of arachidonate metabolism via lipoxygenase and cyclo-oxygenase by 12-HPETE, the product of human platelet fipoxygenasc, Biochem. Biophys. Res Cornmtltl. 89 1273-1280, 1979.
• 44, Turner, S.R. Tainer, J.A., Lynn, W.S. ; Biogenesis of chematoctic molecules by the arachídonate lipoxygenase system of platelets. Nature (Lond.). 257 : 680-6M, 1977.
• 45• Goetzl,• E.I., Pickett, W.C. : The human PMN leukocyte chemotactic activity Of complex hydroxy-eicosatctraenoic acids (HETEsy J. Immunol. 125 : 17894791, 1980.
• 46. Martellí, N.A., Usandivaras, G. : Inhibition of aspirin-induced blonchoconstrictiotl by sodium cromoglygate inhalation. Thorax, 32 : 684-690, 1977.
• 47. Drazcn, J Austen, k.F„ Lewis, REA„ Clark, D.A., Goto, cr., Mar-rat, co rey, E,J, : Comparative airway and vascular activities af leukotrienes C-1 and D in vivo and in vitro, Proe. Natl. Acad. Sci. 77 : 43544358, 1980.
• 48. Smedegard, Hedqvist, P., Dahlên, S,E., Revenös, A., Hammarström, S., Samuelsson, B. : Leukotriene q affects pulmonary and cardiovascular dynamics in monkey, Nature 295 : 327-329, 1982.
• 49. Hanna, C.J„ bach, M.K. , Pares P.D., Schellenberg, R.R. : Slow-reacting substances (Leúkotrienes) contract human airway and pulmonary vascular smooth muscle in vitro. Nature 290 343-344, 1981
• 50 Weiss, J.W., Draaen, J •M, , Coles, N McFadden JER. et all, : effects of leukotciene C in humany. Science 216 ; 196-198, 1982.
• 51. Shethamer, Marom, Z, Kaliner, M. : Immunologic and neuropharmacologic stimulation of Mucous glycoprotein from human in vitro. J. Clin. Invest 66 : 1400* 1980.
• 52. Marorn, Shelhamer, J.H., Bach, M.K., í Morton, DR., Kaliner, M, : Slow-reacting substances, Leukotrienes C, and DI, Increase the release of mucus from human airways in vitro. Am. Rev. Respir. Dis. 126 : 449, 1982'
• 53. Bray, M.A., Cunningham Ford-Hutchinson, A.w., smith, M.J.H. : Imlkotriene : A medialör of vascular permeability. Br. J. Pharmac. 72 : 483-486, 198 {
• 54, Wedmore, C•V., Williams, TJ, Evidence for two types of vascular permeability-increasing mediators : The direct action of histamin and bradÿkiniti; the pOlmymorph pendent action of C5a, leukotriene Ba and formyltripeptide. Br. J, Pharmac. 73 ; 209P, 1981.
• 55. Akinori, V., Kunio, T., Makoto, T., Musashi, Yoshinobu, A. ; Species difference in increased vascular permeability by synthetiz leukotrienc C, and Prostaglandins, 21 : 637-648, 1981.
• 56. Dahlcn, S.E., Björk, J.. Hedqvist, Arfors, KY., Hammarström, et all, : Leukotrienes promote plasma Leukage and Leukocyte adhesion in postcapillary venules : In vivo effects with relevance tc. the acute inflammatory responce, Proc. Natl. Acad. Sci* 18 3887-389A, A9B1
• 57. Drazen, J.M., Austen, K.F. : Effects of intravenous administration of slow-reacting substance of anaphylaxis, Histamine, Bradykinint and prostaglandin F2a on pulmonary mechanics in the quinea-pig. J. Clin. Invest" 53 : 1679-1685, 1974.
• 58. Goetzl, E.J., Brash, A.R.„ Tauber, A.I.; Oates, J.A„ Hubbard, W.C• : Modulation Of human neutrophil function by monohydroxy-eicasatetraenoic acids. Immunology. 39 491-501, 1980.
• 59. Goetzl, E,J. : A role for endogeneus mono-hydroxy-eicosa tetraenoic acids (HETES) in the regulation of human neutrophil migration. Immunology, 40 : 709-719, 1980,
• 60. Tappel, AL., Lundberg, W.D., Byer, P,D, : Effect of temperature and antioxidants upon the lipoxidase catalyzed oxidation of sodium linoleate, Arch, Biochem, Biophys 42 293, 1953.
• 61. Naccache, P.H., Showell, H.s., Baeher, EL. Sha'afi, R.I. : Arachidonic acid induced degranulation of rabbit peritoneal neutrophils• Biochem„ Biophys. Res. Communa 87 292-209, 1979.
• 62. Ammendola, D. Rosa, M., Sorrentinot L : Leucocyte migration and lysosomal enzymes release in rat carregeenin pleurisy. Agents and Actions, 5 : 250-255, 1975
• 63. Goetzl, E.I., Weller, P.F., Sun, F.F. : The regulation of human eosinophil function by endogenous mono-hydroxy-cicosatetraenoic acids (HETE's), J. Immunol, 124 : 926 933, 1980.
• 64, Fehr, J., Jacob, H.S, ; In vitro granulocyte adherence and oin vivo mergination : Two associated Complement-dependent functions. Studies based on the acute neutropenia of filtration leukophoresis• Exp, Med. 146 641-652, 1971
• 65. Bass, D.A., O'Flaherty, J.T., Szeyda, De Chatelet, L.R., McCall, C.E. : Rote ot arachidonic acid in stimulation of hexose transport by human polymorphonuclear leu-• kocytes, Proc, Natl. Acad. sci. 77 5125-5129, 1980.
• 66. Bokoch, G.M„ Reed, P.W. : Inhibition of the neutrcphil oxidative response to chemotactic peptide by inhibitors of arachidonic acid oxygenation. Biochem, Biophys. Res. Commun; 90 : 481.487, 1979.
• 67. Smith, J.W., Steiner, A.L., Parker, C.W. : Human lymphocyte metabolism Effects/ of cyclic and noncyclic nucleotides on stimulation by phytohemagglutunin. J. Clin. vest. SO : 442-8, 1971.
• 68. Kelly, J.P., Johnson, Parker, C.W. : Effect Of Inhibitors of arachidonic acid metabolism on mitogenesis in human lymphocytes; • A possible role of thromboxaney and products of the lipoxygenase pathway. J. Immunol, 122 : 1563-1571, 1979.
• 69. Webb, D.R., Nowouiejki5 1. Healy, Rogers, T.J. : Immunosnpressive properties of leukot.riene D, and E, in vitro. Biochem- Biophys- Res. Commun; 104 1617-1622, 1982,
• 70.Stenson, W.F., Parker, C.W., Sullivan, TJ, ; Augmentation of lgE-Mediated release of histamine by 5-hydroxyeicosatetraenoic acid and 12-Hydroxyeicosatetraenoic acid. Biochem. Biophys. Res. Commun; 96 : 1045-1052, 1980,
• 71. Hammarström, S. Selective inhibition of platelet n-8 lipoxygenase by riynoic acid. Bicchetn, Biophysi Acta, 187 :
• 72, Marone, G•, Hammarström, Lichtenstein, L.M. : An inhibitor of lipoxygenase in hibits histamine release from human basophils. Clin. Immunol. Immunopathc1J 17 117-122,
• 73. Hammarström, S. , Hamberg, M., Samuelsson, B., Dueii, EA., Stawiski, M., Voorhees, .14. : Increased concentrations of nonesterified arachidonie acid, 12 eicosatetraenoic acid, Prostaglandin Fez, and prostaglandin ih epidermis of psoriasis. Proc. Natl. Acad. sci. 72 5130-5134, 1975.
• 74. Brain, S.D.. Camp, R.IYR., Dowd, Black, A.B., et al. : Psoriasis and leukotriene Bf Lancet 762, 1982,
• 75.Allen, B.R*, Littlewood, S.M• : Benoxaprofen: effect on cutaneous lesions in psoriasis, BC Med. J. 285 1982.
• 76. Klickstein, LB., Shaplergh C., Goetzl, E.J. : Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rhetgnütloid arthritis and spondyloarthrìtis. J, Clin, Invest. 66 1166-1170, 1980' 77. Goetzl, F.J., Bianco, NE, Alpert, Sledge, C.B. schur, P.HY : Effects of intra-arti eular corticosteroids in vivo on synovial fluid variables in rheumatoid synovitis. Ann Rheum. Dis. 33 : 420-424, 1974.