KİMYASAL KANSERİJEN MADDELERİN ETKİ MEKANİZMASI

Year 1977, Volume: 30 Issue: 4 , 875 - 882 , 31.12.1977

Mustafa Akpoyraz

https://izlik.org/JA77DP95HE

Abstract

Böylece meydana gelen elektroîii metil katyonları biraz önce konu edilen nükleyik asit ve proteinde mevcut nükleofil bileşenlerle reaksiyona girerler (10).
Nitrozo bileşikler için diğer bir mekanizma Argus (9) tarafından önerilmiştir. Bu öneri dioksamn tavşanların karaciğerinde kanserojen etki göstermesi sonucuna dayanır. Siklik bir eter olan dioksan yapı bakımından, N nitrozo piperidin, N - nitrozo morfolin ve N - nitrozo piperazinin yapısına benzemektedir. Son bileşikler, bu grubun en etkin kanserojen maddeleridir.

Keywords

katyon , piperidin , nükleofil

Ethical Statement

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Thanks

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Kimyasal Kanserijen Maddelerin Etki Mekanizması

https://izlik.org/JA77DP95HE

Abstract

Thus, the electrophilic methyl cations formed react with the nucleophilic components present in the nucleic acids and proteins mentioned above (10). Another mechanism for nitroso compounds was proposed by Argus (9). This suggestion is based on the carcinogenic effect of dioxane on the liver of rabbits. Dioxane, a cyclic ether, is structurally similar to N-nitroso piperidine, N-nitroso morpholine and N-nitroso piperazine. The last compounds are the most potent carcinogens in this group.

Keywords

katyon , piperidin , nükleofil

Ethical Statement

-

Supporting Institution

-

Project Number

-

Thanks

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References

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