Termoregülasyon Ve Ateş

Abstract

İnsan, çevre sıcaklığı değiştiği halde vücut sıcaklığı değişmeyen ve çok dar sınırlar arasında sabit kalan, homoiotermik bir yapıya sahiptir. Bu değişmez sıcaklık vücut iç sıcaklığıdır. Vücut iç sıcaklığı ısı yapımı ile ısı kaybı arasındaki dengeye bağlı olarak sabit tutulur. Vücut iç sıcaklığının dengeli bir şekilde sabit tutulmasına termoregülasyon denir, Termoregülasyon; sıcaklığın azalmasında (soğukda) daha fazla ısı üretimi ve daha az ısı kaybı olmasını gerektirir. Bu vücut sıcaklığının düzenlenmesinde organizmada 1 - Otonom sinir sistemi, 2 - Somatik sistem, 3 - Endokrin sistem ve 4 - Çeşitli davranış biçimleri etkin olmaktadır.

Keywords

• İnsan
• homoiotermik
• vücut sıcaklığ

Thermoregulation And Fever

Abstract

Humans have a homoiothermic structure, where body temperature does not change and remains constant within very narrow limits even when the ambient temperature changes. This constant temperature is the body's internal temperature. The body's internal temperature is kept constant depending on the balance between heat production and heat loss. Keeping the body's internal temperature stable in a balanced way is called thermoregulation. Thermoregulation requires more heat production and less heat loss when the temperature decreases (in cold). In the regulation of this body temperature, 1 - Autonomic nervous system, 2 - Somatic system, 3 - Endocrine system and 4 - Various behavioral patterns are effective in the organism.

Keywords

• İnsan
• homoiotermik
• vücut sıcaklığ

References

1. I. Aclçerman Hochstein H.D„ Zoon K, Browne W., Rivera, E., and Elisberg, B. : interferon fever. ; Absence of humarı Leukocytic pyrogen response to re combinant alfa-interferon. J Leukocyte Bio]. 36 : 17-25, 1984.
2. 2. Akyar AŞ, E, Kansu ; Interlökinler : Yeni biyolojik mediatör sistemi, Doğa TU Tıp ve Ecz. 12 (1) 12, 1988.
3. 3. Baracos V„ Rotemann, H,P., Dinarello. As, Goldberg AL. : Stimulation of muscle protein degratotion and prosta-glandin Eg release by Leukocytic pyrogen (inter leukin-l). A mechanism fon the increased degratation of muscle proteins di ring fever, N. Engl. J Med 308 : 553-558, 1983.
4. 4. Benzinger T.H, : Heat regulation Homeostasis of central temperature in man., physiol. Rev. 49 671-759, 1969.
5. 5. Berne R.M., M.N. Levy : Phsiology. Mosby Comp : 327, 1983.
6. 6. Balatteis CM. : Nevral mechanisms in the pyrogenic and acute-phase respon ses to interlevkin-l intern, J. Nevrosci 38 : 223-232, 1988.
7. 7. Charles M.D., Dinerello ; Interleukin-I and the phathogenesis of the acute phase responce, Nev Engg. Journal of Med. 311 (22) 1413, 1984.
8. 8. Dinarello C.A. : Molecular mechanisms in endoxin fever, Agents an Actions, 13 (5/6) : 470-480, 1983.

9. 9. Dinarello C.A., Cannon. x.G., Wolff S.M., Bernheim H.A., Bevtler B, Cerami A., Figari IS., Pallatino M.A., Jr. and Oconnor J. V. : Tumor necrosis foctor (cachectin is an endogenous pyrogen and induces production of interleukin-I). J. Exp. Med, 163 ; 1433-1450, 1986.
10. 10. Ganong W.F. : Review of Medical Physiology, Lange : 204, 1987. 11. Geen J.H. : An introduction to human physiology, Oxford Medical Pub, : 148, 1983. 12. Gökhan N., H. Çavu$ožIu, A. Kayserilioglu : insan Fizyolojisi, Sermet Matbaasl, 1983. 13, Guyton C.A. : Tekstbook of Medical Phsiology, Saunders Camp. 860, 1987. 14. Hammel H.T., Jackson D.L., Stalwuk J.A.J., Hardy J.D. ve Stromme S,B. : Temperature regülation by hypothamic proportional control with an adjustable setpoints. J. apple Phsiol 18 : 1146-1154, 1963.
11. 15. Heller I-I.C., Thermoregulation sleep and hibernation in mammals, Acta Physiol scandinaw 134 supp 575 : 1.7, 1988.
12. 16. Hensel H. ; Neural processes in thermoregulation, physiol Rev. 53 : 984-1017, 1973.
13. 17. Himms-Hagendl. : Brown atipose tissue metabolism and thermogenesis, An. Rev. Nutr. 5 : 69-94, 1985.
14. 18. Inki M. : Feverl and fever syndrome-current Problems. Jopenese Journal of Physiology 38 : 233-250, 1988.
15. 19. Kelsos, R. Perlmutler M.N. ve Boulonet S.A. : Thermosensltive single-unit aktivity of in witro hypothalamic slices. Am. J Physiol 242, R : 77-84, 1982.
16. 20. Katsan U, S. Izumi Differansce in the mode of acute cold-induced hipotermia between rat and hamster, Japones Journal of physiol. 37 : 207, 1987.
17. 21. Kobayashi S. : Norm-and cold-sensitivite neurons inactive at normal core temperature in rat hypotholamik slices, Brain Res., 362 : 132-139, 1986.
18. 22. Koboyashi S. : Temperoture-Sensitive neurons in the hypotholamus A Nev hypothesis that they act as thermostats, not as transducers. Progress in Neurobiology 32 : 103-135, 1989. 23. Lippold O.C.L. Winton Human physiology, Churcill : 161, 1979.
19. 24, Lipton J.M, Dwyer P.E ve Fossler DE, : Effects of brainsistem Aesions on temperature regulation in hot and cold environments. AM. J. Physioli 226 1365, 1974.
20. 25. Mitchell D ve H.P. Laburn, i)athophysiology temperature regulation The physi ologist 28 (16) : 507-517, 1985.
21. 26. Nakayama T. Thermosensitive nörons in brain Jap, J Physiol 35 : 375-389, 0 1985.
22. 27. Nichols D.G.J ve R.M Locke : Thermogenic Mechanisms in brawn fat «Phsiological Reviews, 64 (1) :1-64, 1984.
23. 28. Pandolf K.B., B.S. Cadarette, M.N. Jawka, A.J. Young, R.P. Froncesconi ve R.R., Gonzalez, Thermoregulatory +esponses of middle aged and young men during dry-heat acclimation, J. Appl. Physiol 65 (I) 65-71, 1988.