Bone Marrow Transplantation and Its Role in Hematological Diseases
Abstract
The aim of bone marrow transplantation (BMT) is tö replace the abnormaıl hematopoetic celis of the patient *ith the normal hematopoetic celis of donor. BMT is 3 types according to the genetic relationship between the donor and recipients : syngeneic, allogeneic and au-
tolog. The most important complications of allogeneic BMT are graft failüre, acute graft-versus-host disease, infections and recurrence of disease. Recurrence of disease is the most significant problem in autolog BMT, also. BMT is being applied in hematologic diseases hike that acute leukemia, chronic myeloid leukemia, aplastic anemia, thalassemia majör, in immüne deficiencies and inborn errors of metabolism, and in the solid tumors which are higly responsible to chemotherapy.
BMT is succesfull in 80 percent of the patients with aplastic anemia who were not transfused before transplantation. BMT is recommended in the second remission of ALL with disease free long-term survival in 25 to 50 per cent of patients, BMT is applied in the first remission of AML. Long-term survival can be achieved in 40-60 percent of patients who are younger than 30 years old. The results of BMT in chronic phase of chronic myeloid leukemia are encouraging,
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References
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