Türkiye'de Böbrek Hastalıklarının Tanısında İğne Biyopsisi
Abstract
Background Since its introduction in 1951, percutaneous needle biopsy has transformed renal disease diagnosis worldwide. Most centers report similar histologic distributions, but our Ankara series revealed an unexpectedly high rate of renal amyloidosis.
Methods We retrospectively reviewed 471 percutaneous renal biopsies performed on 419 patients (256 men, 163 women; age 4–65) at Ankara University in 1963–1966, 1969, and 1971–1972, plus 92 outside cases. Biopsies used Necker or Vim-Silverman needles. Specimens were fixed, paraffin-embedded, and stained (H&E, PAS, Congo red, etc.).
Results Adequate tissue was obtained in 95.8% of attempts. Of 394 diagnostic biopsies, 126 (32.0%) showed amyloidosis—a far higher proportion than reported elsewhere—109 (27.6%) chronic glomerulonephritis, 46 (11.6%) membranous GN, 24 (6.0%) subacute GN, 22 (5.5%) acute GN, 12 (3.0%) chronic pyelonephritis, 11 (2.8%) SLE nephritis, and various other pathologies.
Conclusion The high amyloidosis rate in our Turkish cohort underlines the need for biopsy confirmation in regions where endemic factors—such as FMF—predispose to renal amyloid. Percutaneous biopsy is safe, with a 4% macroscopic bleeding rate and no surgical complications.
Keywords
Kidney biopsy, Renal amyloidosis, Glomerulonephritis, Renal histopathology, Familial Mediterranean fever
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