Böbrek Hastalıklarında Komplement C3, C4 ve Properdin Düzeyleri

Year 1978, Volume: 31 Issue: 4, 1291 - 1300, 31.12.1978

Güner Tokgöz

https://izlik.org/JA74CC46WY

Abstract

Ön Bilgi Komplement sisteminin C3, C4 ve properdin komponentleri immün aracılı böbrek hasarında aktive olur. Hastalığa özgü aktivasyon yolları farklı desenler üretir.

Yöntem 27 kronik glomerülonefrit, 19 amiloid nefrit, 6 akut post-streptokokal glomerülonefrit ve 3 kronik piyelonefritli hastanın yanı sıra 13 sağlıklı kişide tek radyal immünodifüzyonla serum C3, C4 ve properdin düzeyleri ölçüldü.

Bulgular Kronik glomerülonefrit grubunda C3 normal, C4 ve properdin anlamlı düzeyde (p<0,05) düşük bulunarak hem klasik hem alternatif yol aktivasyonu gösterdi. Amiloid nefrit vakalarında C4 yükselmiş (p<0,01), C3 ve properdin normal kaldı. Akut GN’de belirgin C3 düşüklüğü (p<0,001) izlenirken C4 ve properdin normaldi. Kronik piyelonefritli hastalar ile kontrol grubunda tüm komponentler normal sınırlardaydı.

Sonuç C3, C4 ve properdin paterni, farklı nefrit tiplerinin ayırıcı tanısında yardımcı olur. Akut GN’de C3 düşüklüğü, amiloid nefritte C4 yükselmesi, kronik GN’de C4/properdin azalması dikkat çekicidir.

Keywords

Komplement C3 , Komplement C4 , Properdin , Glomerülonefrit , Amiloid nefrit

Quantitative Complement Levels in Renal Diseases

https://izlik.org/JA74CC46WY

Abstract

Background Complement activation accompanies immune‐mediated kidney injury, but patterns of C3, C4, and properdin changes vary by disease. We evaluated these serum components in Turkish patients with chronic glomerulonephritis, amyloid nephritis, acute post-streptococcal GN, and chronic pyelonephritis compared to healthy controls.

Methods Fifty-five patients (27 chronic GN, 19 amyloid nephritis, 6 acute GN, 3 chronic pyelo-nephritis) and 13 controls had serum C3, C4, and properdin measured by single-radial immunodiffusion. Results were expressed in mg/dL and compared using t-tests.

Results Chronic GN patients showed normal C3 with significant C4 and properdin reductions (p<0.05), indicating classical and alternative pathway activation. Amyloid nephritis cases had elevated C4 (p<0.01) but normal C3 and properdin, suggesting isolated C4 activation. Acute GN exhibited marked C3 depletion (p<0.001) with normal C4 and properdin. Chronic pyelonephritis patients and controls had all components within normal ranges.

Conclusion Distinct complement profiles emerge in different renal diseases. C3 depletion is characteristic of acute post-streptococcal GN, C4 elevation of amyloid nephritis, and combined C4/properdin reductions of chronic GN. Quantitative C3, C4, and properdin assays can aid differential diagnosis and understanding of renal immunopathology.

Keywords

Complement C3 , Complement C4 , Properdin , Glomerulonephritis , Amyloidosis

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