Investigation of Humoral Immunity in Children with Down Syndrome (IgA, IgG, IgM Levels)

Gülsan Yavuz

Research Article

Investigation of Humoral Immunity in Children with Down Syndrome (IgA, IgG, IgM Levels)

Year 1979, Volume: 29 Issue: 4, 493 - 506, 31.12.1979

Gülsan Yavuz

https://izlik.org/JA43KY63BC

Abstract

İn our clinic, by peripheral blood chromosome culture 38 Down syndrome cases arc diagnosed as regular trisomi 21. Thc IgA, IgG and IgM levels of these cascs arc ıncasurcd by tri-partigcn immunodiffusion technique. The results arç comparcd by that of controls. İn our study, the Down syndrome cases are found to have normal immunog lobulin levels against infections and the quantitative variations are thought as ac quired results.

Keywords

Humoral Immunity , Down Syndrome , infection

References

1. Penrose, L, St, and Smith, G.F. : Downs Anomaly, Boston, Little, Brown and Co., 1966, s 150, 151
2. Taysi, K., Say, B, : Tlbbi Genetik. Ankara, Hacettepe Üniversitesi Basmevi, 1975, s. 96. (Hacettepe Üniversitesi yaylnlan A—12)
3. Stiehm, E.R., and Fudenberg, H.H. : Sesum levels of immunoglobulin in health and disease : a survey. Pediatrics 27 : 715, 1966 4. Levin St., Nir. E, and Mogilner, B. : T-system immune deficiency in Down's Syndrome. Pediatrics 56 : 123. 1975
5. Oster, J., Mikkelsen, Me, and Nielsen, A. : Mortality and life table in Down's syndrome. Acta Pediatr. Scand. 64 : 322, 1975
6. Rigas, D, Elsasser, P., Hecht, F. : Impaired in vitro response of circulating lymphorytes to phytohemagglutinin in Down's syndrome : Dose and time response curves and relation to relluler immuity. Int. Arch. Allergy. 39 : 587, 1970
7. Skanse, B., and Laurell, C. : The immune - globulins in mongolism. Acta Med, Scand. 172 : 63, 1962
8. Pritham, G.H., Appleton, M.D., and Fluck, E.R. : Biochemical studies in mongolism I : The influence of enviroment on the concentrations and mobilities of plasma proteins. Am. J. Ment. Defic. 67 : 517, 1963
9. Adinolfi, M., Gardner, B., and Martin, W. : Observations on the levels of gamma G, gamma A, gamma M globulins, anti-A and anti-B agglutinins, and antibodies to Escherichia Coli in Down's anomaly. J. Clin. Pathol. 20 : 860, 1967
10. Yokoyama, M., Ball, C., lov K, and Alepa, P. : Immunogenetic studies on mongolism. Am. J. Ment. Defic. 71 : 579, 1967
11. Bårtolozzi, G., Marianelli, L., Franchini, F. : Quantitative dosage of immunoglobulins in subjects with Down's Syndrome, Riv Clin Pediaur. 80 : 459, 1967
12. Rootselaar, F.J. van., and Boerma, F.W. : Serum levels of immunoglobulins in mon golism, in epilepsy and in unclassifield mental deficiency. Psychiatr Neufol. Neurochir. 71 • 501, 1968
13. Rosner, F., Kozinn, P.J., Jervis, G.A. : Levkocyte function and serum immunoglobu lins in Down's syndrome NY State J. Med. 73 : 672, 1973
14. Bernard, R., Sitruk, D.B., Matte:, J.F.: Etude de L'immunite humorale etde la trformation blastique des lymphocytes chez le trisomique 21. Arch. Arch. Fr Pedi3337, 1976
15. Griffiths, A.W., Sylvester, P.E., and Baylis, M. : Serum globulins and infection in mongolism. Am. J. Ment. Defic. Res 11 : 263, 1967
16. Dyggve, H, and Clausen, J. : The serum immunoglobulin level in Down's syndrome. Dev. Med. Child. Neurol. 12 : 193, 1970
17. Kaldor, J., ans Pitt, D. : Down's syndrome and immunoglobulin§. J. Ment. Defic. Res. 15 : 271, 1971
18. Joe Szabados T., Kaiser E, and Otto Sz. : Immunological studies in healthy children with Down's syndrome and in sick children. Ann Immunol Hung. 17 : i4i, 1973
19. Esber, J.H., Barbarich,M ., Menninger, F.F., Meshorer, E, Monedji kova, V., and Rosenkrantz. H. : Hepatitis associated antigen and immunoglobulin composition in patients with Down's anomaly. Am. J. Clili. Pathol. 59 : 872, 1973
20. Hayashi, H., and logrippo, G.A. : Humoral immune status of mongoloid children compared with other congenital defects : Quantitative and qualitive aspects of immunoglobulins. Health Lab. sci. 9 : 203, 1972
21. McMillan, B.C. : Hanson,R .P., Colubjatnikov, R. , and and Sinha, S.K. : The effect of institutionalisation on elevated IgD and IgG levels in patients with Down's syndrome J. Ment. Defic. Res. 19 : 209, 1975
22. Chen. H.P., Walz, D.V., ynd Carroll, J.A. : Immunoglobulinopathy in Down's syndrome. Ohio State Med J. 73 : 27, 1977
24. Seger, R., Buchinger, and Ströder, J. : On the influence of age on immunity in Downs syndrome. Eur J. Pediatr. 124 : 77, 1977
25. Hsia, D, Justice, P., Smith, G., Dowben, R. : Down's syndrome : A Critical review of the biochemical and immunoglogical data Am. J. Dis Child. 121 : 153, 1971
26. Sutnick, A., London, T., Blumberg, B., and Gerstley, B.J. : Susceptibity to leukemia Imunologic factors in Down's syndrome J Natl Cancer. Inst. 47 : 923, 1971
27. Szigeti, R., Revesz, T., Schuler, D. : Cell-mediated immune response in patients with Dowon's syndrome. Acta Pediatr Acad. Sci Hung. 15 : 31, 1974
28. Rundle, A.T., Atkln, J., and Sudell, B. : Association of serum and red cell phenotypes and Australian antigen in Down's syndrome. J Ment. Defic. Res. 18 : 307, 1974 29 • Campion, E.C., and Wangel, A.G. : Australia antigen, autoantibodies and cell - mediated immune
30. Madden, D., Matthew, E, Dietzman, D, Purcell, R., Sever, J., Rostafinski, M,. and Mata, A. : Hepatitis and Down's syndrome Am. J, Ment Defic. 80 : 401, 1976
31. Hayakawa, H., Matsui, 1., Higurashi, Nf., and Kobayashi, N. : Hyperblastic response to dilute P.H.A. In Down's syndrome Lancet 1 : 95, 1968
32. Burgio, G.R., Ugazio, A.G.. and Nespoli, L. : Peripheral blood rosette forming Iymphoctes in Down's syndrome. Experientia 30 : 818, 1974
33. Buckley, R.H., Dees, SC., and O' Fallon, W.M. : Serum immunoglobulins : 1. Levels in normal children and in uncomplicated childhood allergy. Pediatrics 41 : 600, 1968 34. Rowe, D.S., McGregor, I.A., Smith, s.J., Hall, P., and Williams, K. : Plasma immunoglobulin cencentrations In a west' African (Cambian)• community and in a group of healty British adults. Clin. Exp. Immunol. 3 : 63, 1968
35. Allansmith, M., McClellan, B.H., Butterwotrh, m., and Maloney, J.R. : The develop ment of' immunoglobulin levels in man. J. Pediatr. 72 : 276, 1968
36. Kiran, Ö. Say, B. : 0-15 ya9 grubundaki Türk çocuklannda serum Immunoglobulin seviyelerinin geli$mesi ve diEer memleketlerin neticeleriyle karylã¥tlrllmasl. Türkiye Bi limsel Teknik Arastlrma Kurumu Proje No : TAG/ 159 Ankara 1971
37. Alford, A.G. : Immunoglobuin deferminations in the diagnosis of fetal infection. Ped. Clin. N. America. 18 1, 1909, 1971
38. Bese, R. :BüyükoElu, Y. : Yeni doEan'1n immunolojik özellikleri. istanbul Çocuk Kliniži Dergisi •1 1 : 92, 1975
39. Wara, P.W., Ammann, AJ.; Immunologic disorders of childhood. In : Rudolph, A.M. Barnett, H.L., Einhorn, A.H. (eds) : Pediatrics. 16 Th ed. New York, Appleton-CenturyCrofts, 1977. s. 300, 301
40. Miller, ME., Mellman, w.J., Cohen, M M., Kohn, G., and Dietz, W.H. : Depressed immunoglobulin G in newborn infants with Down's syndrome. J. Pediatr. 75 . 996, 1969
41. Appleton, M.D., and Pritham, G.H. : Biochemical studies in mongolism 11 : The influence of age and sex on plazma Proteins. Am. J. Ment. Defic. 67 : 521, 1963
42 Hollinger, F.B., Goyal, R.K., Hersh, T., Rowell, H.c., Schulman, R.J., and Melniok, J.I. : Immun response to hepatitis virus type B in Down's syndrome and other mentally retarted patients. Am. J. Epidemiol. 95 : 356, 1972
43. Marchalonis, J.J. : Cell Cooperation in immune responsis In : Fudenberg, H.H., Stites, D.P., Cadwell, JL., Wells, J.V. (eds) : Basic and Clinical Immunology. Los Altos, Lange Medical Publications, 1976, s. 88.89.90-91.
44. Berg, T., and Johansson, S.G.O. : Immunoglobulin levels during childhood, with spe cial regard to IGE. Acta Pacdiats. Scand. 58 : 513, 1969 45. Butterworth, M., McClellan, B., Allansmith, M. : Ingluence of sex on immunoglobulin levels. Nature 214 : 1224, 1967

Down Sendromlu Çocuklarda Humoral İmmunitenin İncelenmesi (IgA, IgG, IgM Düzeyleri)

Year 1979, Volume: 29 Issue: 4, 493 - 506, 31.12.1979

Gülsan Yavuz

https://izlik.org/JA43KY63BC

Abstract

Kliniğimizde periferik kan kromozom kültürleri yapılarak regüler trisomi 21 tanısı alan 38 Down sendromlu olgumuzun IgA, IgG ve IgM düzeyleri tri-partigen immunodiffüzyon yöntemi ile ölçüldü. Sonuçlar sağlıklı Türk çocuklarından oluşan kontrol yuplarımız ile karşılaştırıldı. Calışmamızda, Down sendromlu olgularımızın infeksiyonlara karşı yeterli düzeyde immunoglobulin yaparak yanıt verdiği saptanıldı ve immunoglobulin düzeylerinde görülen bu değişikliklerin kazanılmış sonuçlar olabileceği tartışıldı.

Keywords

Humoral Bağışıklık , Down Sendromu , Enfeksiyon

References

1. Penrose, L, St, and Smith, G.F. : Downs Anomaly, Boston, Little, Brown and Co., 1966, s 150, 151
2. Taysi, K., Say, B, : Tlbbi Genetik. Ankara, Hacettepe Üniversitesi Basmevi, 1975, s. 96. (Hacettepe Üniversitesi yaylnlan A—12)
3. Stiehm, E.R., and Fudenberg, H.H. : Sesum levels of immunoglobulin in health and disease : a survey. Pediatrics 27 : 715, 1966 4. Levin St., Nir. E, and Mogilner, B. : T-system immune deficiency in Down's Syndrome. Pediatrics 56 : 123. 1975
5. Oster, J., Mikkelsen, Me, and Nielsen, A. : Mortality and life table in Down's syndrome. Acta Pediatr. Scand. 64 : 322, 1975
6. Rigas, D, Elsasser, P., Hecht, F. : Impaired in vitro response of circulating lymphorytes to phytohemagglutinin in Down's syndrome : Dose and time response curves and relation to relluler immuity. Int. Arch. Allergy. 39 : 587, 1970
7. Skanse, B., and Laurell, C. : The immune - globulins in mongolism. Acta Med, Scand. 172 : 63, 1962
8. Pritham, G.H., Appleton, M.D., and Fluck, E.R. : Biochemical studies in mongolism I : The influence of enviroment on the concentrations and mobilities of plasma proteins. Am. J. Ment. Defic. 67 : 517, 1963
9. Adinolfi, M., Gardner, B., and Martin, W. : Observations on the levels of gamma G, gamma A, gamma M globulins, anti-A and anti-B agglutinins, and antibodies to Escherichia Coli in Down's anomaly. J. Clin. Pathol. 20 : 860, 1967
10. Yokoyama, M., Ball, C., lov K, and Alepa, P. : Immunogenetic studies on mongolism. Am. J. Ment. Defic. 71 : 579, 1967
11. Bårtolozzi, G., Marianelli, L., Franchini, F. : Quantitative dosage of immunoglobulins in subjects with Down's Syndrome, Riv Clin Pediaur. 80 : 459, 1967
12. Rootselaar, F.J. van., and Boerma, F.W. : Serum levels of immunoglobulins in mon golism, in epilepsy and in unclassifield mental deficiency. Psychiatr Neufol. Neurochir. 71 • 501, 1968
13. Rosner, F., Kozinn, P.J., Jervis, G.A. : Levkocyte function and serum immunoglobu lins in Down's syndrome NY State J. Med. 73 : 672, 1973
14. Bernard, R., Sitruk, D.B., Matte:, J.F.: Etude de L'immunite humorale etde la trformation blastique des lymphocytes chez le trisomique 21. Arch. Arch. Fr Pedi3337, 1976
15. Griffiths, A.W., Sylvester, P.E., and Baylis, M. : Serum globulins and infection in mongolism. Am. J. Ment. Defic. Res 11 : 263, 1967
16. Dyggve, H, and Clausen, J. : The serum immunoglobulin level in Down's syndrome. Dev. Med. Child. Neurol. 12 : 193, 1970
17. Kaldor, J., ans Pitt, D. : Down's syndrome and immunoglobulin§. J. Ment. Defic. Res. 15 : 271, 1971
18. Joe Szabados T., Kaiser E, and Otto Sz. : Immunological studies in healthy children with Down's syndrome and in sick children. Ann Immunol Hung. 17 : i4i, 1973
19. Esber, J.H., Barbarich,M ., Menninger, F.F., Meshorer, E, Monedji kova, V., and Rosenkrantz. H. : Hepatitis associated antigen and immunoglobulin composition in patients with Down's anomaly. Am. J. Clili. Pathol. 59 : 872, 1973
20. Hayashi, H., and logrippo, G.A. : Humoral immune status of mongoloid children compared with other congenital defects : Quantitative and qualitive aspects of immunoglobulins. Health Lab. sci. 9 : 203, 1972
21. McMillan, B.C. : Hanson,R .P., Colubjatnikov, R. , and and Sinha, S.K. : The effect of institutionalisation on elevated IgD and IgG levels in patients with Down's syndrome J. Ment. Defic. Res. 19 : 209, 1975
22. Chen. H.P., Walz, D.V., ynd Carroll, J.A. : Immunoglobulinopathy in Down's syndrome. Ohio State Med J. 73 : 27, 1977
24. Seger, R., Buchinger, and Ströder, J. : On the influence of age on immunity in Downs syndrome. Eur J. Pediatr. 124 : 77, 1977
25. Hsia, D, Justice, P., Smith, G., Dowben, R. : Down's syndrome : A Critical review of the biochemical and immunoglogical data Am. J. Dis Child. 121 : 153, 1971
26. Sutnick, A., London, T., Blumberg, B., and Gerstley, B.J. : Susceptibity to leukemia Imunologic factors in Down's syndrome J Natl Cancer. Inst. 47 : 923, 1971
27. Szigeti, R., Revesz, T., Schuler, D. : Cell-mediated immune response in patients with Dowon's syndrome. Acta Pediatr Acad. Sci Hung. 15 : 31, 1974
28. Rundle, A.T., Atkln, J., and Sudell, B. : Association of serum and red cell phenotypes and Australian antigen in Down's syndrome. J Ment. Defic. Res. 18 : 307, 1974 29 • Campion, E.C., and Wangel, A.G. : Australia antigen, autoantibodies and cell - mediated immune
30. Madden, D., Matthew, E, Dietzman, D, Purcell, R., Sever, J., Rostafinski, M,. and Mata, A. : Hepatitis and Down's syndrome Am. J, Ment Defic. 80 : 401, 1976
31. Hayakawa, H., Matsui, 1., Higurashi, Nf., and Kobayashi, N. : Hyperblastic response to dilute P.H.A. In Down's syndrome Lancet 1 : 95, 1968
32. Burgio, G.R., Ugazio, A.G.. and Nespoli, L. : Peripheral blood rosette forming Iymphoctes in Down's syndrome. Experientia 30 : 818, 1974
33. Buckley, R.H., Dees, SC., and O' Fallon, W.M. : Serum immunoglobulins : 1. Levels in normal children and in uncomplicated childhood allergy. Pediatrics 41 : 600, 1968 34. Rowe, D.S., McGregor, I.A., Smith, s.J., Hall, P., and Williams, K. : Plasma immunoglobulin cencentrations In a west' African (Cambian)• community and in a group of healty British adults. Clin. Exp. Immunol. 3 : 63, 1968
35. Allansmith, M., McClellan, B.H., Butterwotrh, m., and Maloney, J.R. : The develop ment of' immunoglobulin levels in man. J. Pediatr. 72 : 276, 1968
36. Kiran, Ö. Say, B. : 0-15 ya9 grubundaki Türk çocuklannda serum Immunoglobulin seviyelerinin geli$mesi ve diEer memleketlerin neticeleriyle karylã¥tlrllmasl. Türkiye Bi limsel Teknik Arastlrma Kurumu Proje No : TAG/ 159 Ankara 1971
37. Alford, A.G. : Immunoglobuin deferminations in the diagnosis of fetal infection. Ped. Clin. N. America. 18 1, 1909, 1971
38. Bese, R. :BüyükoElu, Y. : Yeni doEan'1n immunolojik özellikleri. istanbul Çocuk Kliniži Dergisi •1 1 : 92, 1975
39. Wara, P.W., Ammann, AJ.; Immunologic disorders of childhood. In : Rudolph, A.M. Barnett, H.L., Einhorn, A.H. (eds) : Pediatrics. 16 Th ed. New York, Appleton-CenturyCrofts, 1977. s. 300, 301
40. Miller, ME., Mellman, w.J., Cohen, M M., Kohn, G., and Dietz, W.H. : Depressed immunoglobulin G in newborn infants with Down's syndrome. J. Pediatr. 75 . 996, 1969
41. Appleton, M.D., and Pritham, G.H. : Biochemical studies in mongolism 11 : The influence of age and sex on plazma Proteins. Am. J. Ment. Defic. 67 : 521, 1963
42 Hollinger, F.B., Goyal, R.K., Hersh, T., Rowell, H.c., Schulman, R.J., and Melniok, J.I. : Immun response to hepatitis virus type B in Down's syndrome and other mentally retarted patients. Am. J. Epidemiol. 95 : 356, 1972
43. Marchalonis, J.J. : Cell Cooperation in immune responsis In : Fudenberg, H.H., Stites, D.P., Cadwell, JL., Wells, J.V. (eds) : Basic and Clinical Immunology. Los Altos, Lange Medical Publications, 1976, s. 88.89.90-91.
44. Berg, T., and Johansson, S.G.O. : Immunoglobulin levels during childhood, with spe cial regard to IGE. Acta Pacdiats. Scand. 58 : 513, 1969 45. Butterworth, M., McClellan, B., Allansmith, M. : Ingluence of sex on immunoglobulin levels. Nature 214 : 1224, 1967

There are 40 citations in total.

Details

Primary Language	English
Subjects	Infant and Child Health
Journal Section	Research Article
Authors	Gülsan Yavuz This is me
Publication Date	December 31, 1979
IZ	https://izlik.org/JA43KY63BC
Published in Issue	Year 1979 Volume: 29 Issue: 4

Cite

APA	Yavuz, G. (1979). Investigation of Humoral Immunity in Children with Down Syndrome (IgA, IgG, IgM Levels). Ankara Üniversitesi Tıp Fakültesi Mecmuası, 29(4), 493-506. https://izlik.org/JA43KY63BC
AMA	1.Yavuz G. Investigation of Humoral Immunity in Children with Down Syndrome (IgA, IgG, IgM Levels). Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1979;29(4):493-506. https://izlik.org/JA43KY63BC
Chicago	Yavuz, Gülsan. 1979. “Investigation of Humoral Immunity in Children With Down Syndrome (IgA, IgG, IgM Levels)”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 29 (4): 493-506. https://izlik.org/JA43KY63BC.
EndNote	Yavuz G (December 1, 1979) Investigation of Humoral Immunity in Children with Down Syndrome (IgA, IgG, IgM Levels). Ankara Üniversitesi Tıp Fakültesi Mecmuası 29 4 493–506.
IEEE	[1]G. Yavuz, “Investigation of Humoral Immunity in Children with Down Syndrome (IgA, IgG, IgM Levels)”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 29, no. 4, pp. 493–506, Dec. 1979, [Online]. Available: https://izlik.org/JA43KY63BC
ISNAD	Yavuz, Gülsan. “Investigation of Humoral Immunity in Children With Down Syndrome (IgA, IgG, IgM Levels)”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 29/4 (December 1, 1979): 493-506. https://izlik.org/JA43KY63BC.
JAMA	1.Yavuz G. Investigation of Humoral Immunity in Children with Down Syndrome (IgA, IgG, IgM Levels). Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1979;29:493–506.
MLA	Yavuz, Gülsan. “Investigation of Humoral Immunity in Children With Down Syndrome (IgA, IgG, IgM Levels)”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 29, no. 4, Dec. 1979, pp. 493-06, https://izlik.org/JA43KY63BC.
Vancouver	1.Gülsan Yavuz. Investigation of Humoral Immunity in Children with Down Syndrome (IgA, IgG, IgM Levels). Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1979 Dec. 1;29(4):493-506. Available from: https://izlik.org/JA43KY63BC

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